Cancer: Epidemiology, Racial, and Geographical Disparities

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Molecular Biomarkers for Cancer Diagnosis and Therapy

Abstract

Cancer is a complex and multifaceted disease that affects millions of people worldwide. The epidemiology of cancer is a critical area of research that seeks to understand the incidence, prevalence, and distribution of cancer in different populations. Epidemiological studies have revealed that cancer is a major public health concern, with an estimated 19.3 million new cases and ten million deaths worldwide in 2020 alone. The incidence of cancer varies widely across different regions and populations, with some cancers being more common in certain geographic areas or ethnic groups. Several risk factors have been identified for various types of cancer, including lifestyle factors such as tobacco use, alcohol consumption, and poor diet, as well as genetic and environmental factors. Understanding these risk factors is essential for develo** effective prevention and treatment strategies for cancer. Advances in technology and research have led to significant improvements in cancer diagnosis and treatment in recent years. However, much work remains to be done to reduce the burden of cancer on individuals and society as a whole. Ongoing research in the epidemiology of cancer will continue to play a critical role in advancing our understanding of this complex disease and develo** new approaches to prevention and treatment.

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References

  • American Cancer Society (2022) Cancer facts & figures 2022. American Cancer Society, Atlanta

    Google Scholar 

  • Berenguer CV, Pereira F, Câmara JS, Pereira JAM (2023) Underlying features of prostate cancer—statistics, risk factors, and emerging methods for its diagnosis. Curr Oncol 30(2):2300–2321. https://doi.org/10.3390/curroncol30020178

    Article  PubMed  PubMed Central  Google Scholar 

  • Cancer.Net (2012) ‘Cervical Cancer- Statistics’. https://www.cancer.net/cancer-types/cervical-cancer/statistics. Accessed 25 June 2012

  • Collin LJ, Gaglioti AH, Beyer KM, Zhou Y, Moore MA, Nash R, Switchenko JM, Miller-Kleinhenz JM, Ward KC, McCullough LE (2021) Neighborhood-level redlining and lending bias are associated with breast cancer mortality in a large and diverse metropolitan area. Cancer Epidemiol Biomark Prev 30(1):53–60

    Article  CAS  Google Scholar 

  • Dagobeth EEV, Roja GAN, Valdelamar JCH, Lozada-Martínez ID, Causado AS, Narvaez-Rojas AR (2022) Surgical outcomes and factors associated with postoperative complications of colorectal cancer in a Colombian Caribbean population: results from a regional referral hospital. Cancer Rep 6(4):e1766. https://doi.org/10.1002/cnr2.1766

    Article  CAS  Google Scholar 

  • De Vuyst H, Alemany L, Lacey C, Chibwesha CJ, Sahasrabuddhe V, Banura C, Denny L, Parham GP (2013) The burden of human papillomavirus infections and related diseases in sub-Saharan Africa. Vaccine 31(Suppl 5(05)):F32

    Article  PubMed  PubMed Central  Google Scholar 

  • Dong M, Cioffi G, Wang J et al (2020) Sex differences in cancer incidence and survival: a pan-cancer analysis. Cancer Epidemiol Biomark Prev 29(7):1389–1397

    Article  Google Scholar 

  • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386

    Article  CAS  PubMed  Google Scholar 

  • Ghoncheh M, Pournamdar Z, Salehiniya H (2016) Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev 17(S3):43–46

    Article  PubMed  Google Scholar 

  • Henrot P, Beaufils F, Thumerel M, Eyraud E, Boudoussier A, Begueret H, Maurat E, Girodet PO, Marthan R, Berger P, Dupin I, Zysman M (2021) Circulating fibrocytes as a new tool to predict lung cancer progression after surgery? Eur Respir J 58(6):2101221. https://doi.org/10.1183/13993003.01221-2021

    Article  PubMed  Google Scholar 

  • Liu C, Ma Y, Qin Q, Wang P, Luo Y, Xu P, Cui Y (2023) Epidemiology of esophageal cancer in 2020 and projections to 2030 and 2040. Thorac Cancer 14(1):3–11. https://doi.org/10.1111/1759-7714.14745

    Article  PubMed  Google Scholar 

  • Lynch EE, Malcoe LH, Laurent SE, Richardson J, Mitchell BC, Meier HCS (2021) The legacy of structural racism: associations between historic redlining, current mortgage lending, and health. SSM Popul Health 14:100793

    Article  PubMed  PubMed Central  Google Scholar 

  • Marmot M, Friel S, Bell R, Houweling TA, Taylor S (2008) Commission on social determinants of health: closing the gap in a generation: health equity through action on the social determinants of health. Lancet 372(9650):1661–1669

    Article  PubMed  Google Scholar 

  • Mattiuzzi C, Lippi G (2019) Current cancer epidemiology. J Epidemiol Glob Health 9(4):217–222

    Article  PubMed  PubMed Central  Google Scholar 

  • Miller KD, Fidler-Benaoudia M, Keegan TH, Hipp HS, Jemal A, Siegel RL (2020) Cancer statistics for adolescents and young adults, 2020. CA Cancer J Clin 70(6):443–459

    Article  PubMed  Google Scholar 

  • Mittal S, El-Serag HB (2013) Epidemiology of hepatocellular carcinoma: consider the population. J Clin Gastroenterol 47(Suppl(0)):S2

    Article  PubMed  PubMed Central  Google Scholar 

  • Morgan E, Arnold M, Camargo MC, Gini A, Kunzmann AT, Matsuda T, Meheus F, Verhoeven RHA, Vignat J, Laversanne M, Ferlay J, Soerjomataram I (2022) The current and future incidence and mortality of gastric cancer in 185 countries, 2020–40: a population-based modelling study. EClinicalMedicine 47:101404. https://doi.org/10.1016/j.eclinm.2022.101404

    Article  PubMed  PubMed Central  Google Scholar 

  • NCI (2015) Risk factors: age. https://www.cancer.gov/about-cancer/causes-prevention/risk/age. Accessed 13 Jun 2023

  • Nelson DE, Mowery P, Asman K, Pederson LL, O'Malley PM, Malarcher A, Maibach EW, Pechacek TF (2008) Long-term trends in adolescent and young adult smoking in the United States: metapatterns and implications. Am J Public Health 98(5):905–915

    Article  PubMed  PubMed Central  Google Scholar 

  • Rawla P, Barsouk A (2019) Epidemiology of gastric cancer: global trends, risk factors and prevention. Gastroenterol Rev 14(1):26–38. https://doi.org/10.5114/pg.2018.80001

    Article  CAS  Google Scholar 

  • Rumgay H, Arnold M, Ferlay J, Lesi O, Cabasag CJ, Vignat J, Laversanne M, McGlynn KA, Soerjomataram I (2022) Global burden of primary liver cancer in 2020 and predictions to 2040. J Hepatol 77(6):1598–1606. https://doi.org/10.1016/j.jhep.2022.08.021

    Article  PubMed  PubMed Central  Google Scholar 

  • Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72(1):7–33

    Article  PubMed  Google Scholar 

  • Siegel RL, Miller KD, Goding Sauer A et al (2020) Colorectal cancer statistics, 2020. CA Cancer J Clin 70(3):145–164

    Article  PubMed  Google Scholar 

  • Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, Arbyn M, Basu P, Bray F, Vaccarella S (2023) Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO global cervical cancer elimination initiative. Lancet Glob Health 11(2):e197–e206. https://doi.org/10.1016/S2214-109X(22)00501-0

    Article  CAS  PubMed  Google Scholar 

  • Sung H, Ferlay J, Siegel RL et al (2020) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.21660

    Article  CAS  Google Scholar 

  • The Burden of Cancer (2023) The Cancer Atlas. http://canceratlas.cancer.org/Xoh. Accessed 8 Jun 2023

  • Torre LA, Siegel RL, Ward EM, Jemal A (2016) Global cancer incidence and mortality rates and trends—an update. Cancer Epidemiol Biomark Prev 25(1):16–27

    Article  Google Scholar 

  • Uhlenhopp DJ, Then EO, Sunkara T, Gaduputi V (2020) Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin J Gastroenterol 13(6):1010–1021

    Article  PubMed  Google Scholar 

  • Vaccarella S, Lortet-Tieulent J, Plummer M, Franceschi S, Bray F (2013) Worldwide trends in cervical cancer incidence: impact of screening against changes in disease risk factors. Eur J Cancer 49(15):3262–3273

    Article  PubMed  Google Scholar 

  • Ward E, Jemal A, Cokkinides V, Singh GK, Cardinez C, Ghafoor A, Thun M (2004) Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin 54(2):78–93

    Article  PubMed  Google Scholar 

  • White MC, Holman DM, Boehm JE, Peipins LA, Grossman M, Henley SJ (2014) Age and cancer risk: a potentially modifiable relationship. Am J Prev Med 46(3 Suppl 1):S7–S15. https://doi.org/10.1016/j.amepre.2013.10.029

    Article  PubMed  PubMed Central  Google Scholar 

  • Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA (2004) Environmental and chemical carcinogenesis. Semin Cancer Biol 14(6):473–486

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization (2019) Projections of mortality and causes of death, 2016 to 2060. WHO, Geneva. https://www.who.int/healthinfo/global_burden_disease/projections/en/. Accessed 9 July 2019

    Google Scholar 

  • Yardim-Akaydin S, Karahalil B, Baytas SN (2022) New therapy strategies in the management of breast cancer. Drug Discov Today 27(6):1755–1762. https://doi.org/10.1016/j.drudis.2022.03.014

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Luo G, Etxeberria J, Hao Y (2021) Global patterns and trends in lung cancer incidence: a population-based study. J Thorac Oncol 16(6):933–944

    Article  PubMed  Google Scholar 

  • Zhang JG, Wang H, Gu XF, Wang XY, Wang WJ, Du LB CHL, Zhang X, Shi JH, Zhao YQ, Ma L, Liu YY, Huang JX, Cao J, Fan YP, Li L, Feng CY, Zhu Q, Du JC, China Working Group on Colorectal Cancer Survey (2022) Status and associated factors of cross-regional healthcare-seeking among patients with advanced colorectal cancer in China: a multicenter cross-sectional study. Ann Translat Med 10(6):342. https://doi.org/10.21037/atm-22-1003

    Article  CAS  Google Scholar 

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Correspondence to Ranbir Chander Sobti .

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Sobti, R.C., Thakur, M., Kaur, T. (2024). Cancer: Epidemiology, Racial, and Geographical Disparities. In: Sobti, R.C., Sugimura, H., Sobti, A. (eds) Molecular Biomarkers for Cancer Diagnosis and Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-99-3746-2_3

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  • DOI: https://doi.org/10.1007/978-981-99-3746-2_3

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