Autoimmune Diagnostics

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In Vitro Diagnostic Industry in China

Abstract

Autoimmunity refers to the destruction of the body’s immune tolerance mechanism under the action of internal and external factors. On the one hand, the autoimmune B cells in the circulation increase in large quantities, and on the other hand, the self-reactive helper T lymphocytes promote the destruction of the self-tolerance of B lymphocytes. As a result, the immune system responds to its own components, producing antibodies against the self-components (auto-antibodies) and/or sensitized lymphocytes [1, 2].

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References

  1. Patakas A, Benson RA, Withers DR, Conigliaro P, McInnes IB, Brewer JM, et al.Th17 effector cells surpport B cell responses outside of germinal centres PloS One 2012;7:e49715.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Taylor JJ, Martinez RJ, Titcombe PJ, Barsness LO, Thomas SR, Zhang N,et al.Deletion and angergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen.J Exp Med 2012;209:2065–2077.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Li M, Zhang W, Leng X, et al. Chinese SLE Treatment and Research Group (CSTAR) registry: I. Major clinical characteristics of Chinese patients with systemic lupuserythematosus. Lupus. 2013;22(11):1192–9. https://doi.org/10.1177/0961203313499086.

    Article  CAS  PubMed  Google Scholar 

  4. Rees F, Doherty M, Grainge MJ, et al. The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies. Rheumatology. 2017;56(11):1945–61. https://doi.org/10.1093/rheumatology/kex260.

    Article  PubMed  Google Scholar 

  5. ** S, Li M, Fang Y, et al. Chinese registry of rheumatoid arthritis (CREDIT): II. Prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis. Arthritis Res Ther. 2017;19(1):251. https://doi.org/10.1186/s13075-017-1457-z.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Granerod J, Ambrose HE, Davies NW, et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010;10(12):835–44. https://doi.org/10.1016/S1473-3099(10)70222-X.

    Article  PubMed  Google Scholar 

  7. Dutra LA, Abrantes F, Toso FF, et al. Autoimmune encephalitis: a review of diagnosis and treatment. Arq Neuropsiquiatr. 2018;76:41–9.

    Article  PubMed  Google Scholar 

  8. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295–306. https://doi.org/10.1111/j.1538-7836.2006.01753.x.

    Article  CAS  PubMed  Google Scholar 

  9. Pache F, Wildemann B, Paul F, Jarius S. Neuromyelitis optica [Neuromyelitis optica]. Fortschr Neurol Psychiatr. 2017;85(2):100–14. German. Epub 2017 Feb 24. https://doi.org/10.1055/s-0042-124186.

    Article  PubMed  Google Scholar 

  10. Oliveira LC, Porta G, Marin ML, Bittencourt PL, Kalil J, Goldberg AC. Autoimmune hepatitis, HLA and extended haplotypes. Autoimmun Rev. 2011;10(4):189–93. Epub 2010 Oct 7. https://doi.org/10.1016/j.autrev.2010.09.024.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Qiu** Yu .

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Qiu** Yu, Haifeng **, Yanchun Guo and Tianshi Wang are employees of Shenzhen YHLO Biotech Co., Ltd., Shenzhen, China.

Xuexin Deng is an employee of Tellgen Corporation, Shanghai, China.

Mu Wang is an employee of Shanghai Advanced Clinical Laboratory Science Co., Ltd (ACLS), Shanghai, China.

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© 2023 Shanghai Scientific and Technical Publishers

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**, H., Guo, Y., Wang, T., Yu, Q., Deng, X., Wang, M. (2023). Autoimmune Diagnostics. In: Song, H., Dai, L. (eds) In Vitro Diagnostic Industry in China. Springer, Singapore. https://doi.org/10.1007/978-981-99-3110-1_5

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  • DOI: https://doi.org/10.1007/978-981-99-3110-1_5

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  • Publisher Name: Springer, Singapore

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  • Online ISBN: 978-981-99-3110-1

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