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Dielektrisch modulierter Biosensor basierend auf vertikalem Tunnel-Feldeffekt-Transistor

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Intelligente Nano-Bio-Geräte der nächsten Generation

Zusammenfassung

Dieses Kapitel diskutiert die Anwendung von vertikalen Tunnel-FET (VTFET) als dielektrisch modulierter, markierungsfreier Biosensor. Es werden verschiedene Merkmale dieses Biosensors vorgestellt, wobei sich die Analysen auf die Steigerung der Empfindlichkeit, die untere Nachweisgrenze und die Reaktionszeit konzentrieren. Das Konzept der Sensorik basiert auf der dielektrischen Modulation, bei der die Inkubation der Biomoleküle durch einen Isolator dargestellt wird. Dessen Dielektrizitätskonstante entspricht der Dielektrizitätskonstante des Ziel-Biomoleküls, da verschiedene Biomoleküle eine einzigartige Dielektrizitätskonstante aufweisen. Das vorgeschlagene Sensordesign wird mit einem Ansatz des Technology-Computer-Aided-Designs (TCAD) umgesetzt, indem relevante physikbasierte Simulationsmodelle integriert werden. Mit Blick auf den praktischen Nutzen des Geräts wurde die Studie erweitert, um seine Leistung unter nichtidealen Bedingungen wie sterischer Behinderung oder unregelmäßiger Ausrichtung zu analysieren. Abschließend wird der Status des vorgeschlagenen Sensors durch den Vergleich verschiedener Sensorparameter einiger bedeutender, in der Literatur verfügbarer Arbeiten zum markierungsfreien Biosensor auf TFET-Basis dargestellt.

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Authors and Affiliations

  1. Department of Electronics and Communication, National Institute of Technology Calicut, Kozhikode, Kerala, Indien

    Vandana Devi Wangkheirakpam, Brinda Bhowmick & Puspa Devi Pukhrambam

  2. Department of Electronics and Communication, National Institute of Technology Silchar, Silchar, Assam, Indien

    Vandana Devi Wangkheirakpam, Brinda Bhowmick & Puspa Devi Pukhrambam

Authors
  1. Vandana Devi Wangkheirakpam
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  2. Brinda Bhowmick
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  3. Puspa Devi Pukhrambam
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Correspondence to Vandana Devi Wangkheirakpam .

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Editors and Affiliations

  1. School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India

    Gorachand Dutta

  2. School of Mines and Metallurgy, Kazi Nazrul University, Asansol, West Bengal, India

    Arindam Biswas

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Wangkheirakpam, V.D., Bhowmick, B., Pukhrambam, P.D. (2024). Dielektrisch modulierter Biosensor basierend auf vertikalem Tunnel-Feldeffekt-Transistor. In: Dutta, G., Biswas, A. (eds) Intelligente Nano-Bio-Geräte der nächsten Generation. Springer Spektrum, Singapore. https://doi.org/10.1007/978-981-97-2087-3_9

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