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Olefin-Accelerated Solid-State C–N Cross-Coupling Using Mechanochemistry

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Palladium-Catalyzed Mechanochemical Cross-Coupling Reactions

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Abstract

Palladium-catalyzed cross-coupling reactions are one of the most powerful and versatile methods to synthesize a wide range of complex functionalized molecules. However, the development of solid-state cross-coupling reactions remains extremely limited. Here, the author reported a rational strategy that provides a general entry to palladium-catalyzed Buchwald-Hartwig cross-coupling reactions in the solid state. The key finding of this study is that olefin additives can act as efficient molecular dispersants for the palladium-based catalyst in solid-state media to facilitate the challenging solid-state cross-coupling. Beyond the immediate utility of this protocol, this strategy could inspire the development of industrially attractive solvent-free palladium-catalyzed cross-coupling processes for other valuable synthetic targets.

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  1. Asahi Kasei, Kawasaki, Kanagawa, Japan

    Tamae Seo

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Seo, T. (2024). Olefin-Accelerated Solid-State C–N Cross-Coupling Using Mechanochemistry. In: Palladium-Catalyzed Mechanochemical Cross-Coupling Reactions. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-97-1991-4_2

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