Abstract
Microparticles are one of the drug delivery systems used to sustain the release of drugs. The purpose of this work was to forumlate sustained-release microparticles of ketoprofen (KTP) for ocular delivery. The microparticles were prepared by the method of quasi emulsion-solvent diffusion using the design of experiments, the MINITAB 16 was used to analyze the results. EC:KTP mass ratio (%), PVA concentration (m/v %) and stirring speed (rpm) were selected as factors. Encapsulation efficiency rate (EE%) and in vitro release after 6h (REL6%) were selected as responses. The central composite design (CCD) was used for the formulation optimization. The results indicated that the optimal microparticles formulated has an EE = 78.89%, REL6% = 39.98% for a EC:KTP mass ratio = 80.59%, PVA concentration = 0.52% and stirring speed = 477.11 rpm. The optical microscope was used to determine the morphology of the optimized microparticles, they were of spherical shape. The in vitro dissolution at 35 °C in a medium with pH = 7.4 gave a sustained release in which 36.98% of ketoprofen was released after 6 h. According to the results obtained, the microparticles of ketoprofen can be used for the ocular sustained release.
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Badaoui, F.Z., Meziani, S., Benmegoura, L., Hedna, S.D. (2024). Formulation and Optimization of Sustained Release Microparticles of Ketoprofen. In: Hamamda, S., Zahaf, A., Sementsov, Y., Nedilko, S., Ivanenko, K. (eds) Proceedings of the 2nd International Conference of Nanotechnology for Environmental Protection and Clean Energy Production. ICNEP 2023. Springer Proceedings in Materials, vol 45. Springer, Singapore. https://doi.org/10.1007/978-981-97-1916-7_6
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DOI: https://doi.org/10.1007/978-981-97-1916-7_6
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