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A Recent Update of Graphene-Based Nanomaterials for Biomedical Applications: Focusing on Drug Delivery and Tissue Engineering

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Carbon-Based Nanomaterials

Part of the book series: Smart Nanomaterials Technology ((SNT))

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Abstract

In recent times, there has been a surge in the use of nanomaterials within biomedical. These materials have gained significant interest for their potential in several applications, including the development of artificial organs and tissues, drug delivery systems, and gene therapy. This increasing interest may be attributed to the unique properties of nanomaterials, namely their decreased dimensions and expanded surface area. Graphene and its derivatives have garnered significant attention across various areas, with a particular emphasis on biomedical applications. This preference stems from the exceptional structural, mechanical, optical, thermal, and electrical properties of graphene and its substantial surface area. These characteristics facilitate efficient and effective drug-loading processes. The use of graphene and its derivative materials in biomedical settings has significant importance in several domains, including tissue engineering, biosensor applications, and gene transfer, alongside its established role in controlled drug release applications. In this section, drug delivery and tissue engineering issues are specifically addressed. Graphene and its derivatives have exceptional characteristics as drug delivery carriers, rendering them very promising for applications involving materials with superior loading efficiency, targeting capabilities, imaging capabilities, sensing abilities, and stimulus-sensitive release qualities. These materials, which also aid in the restoration of the extracellular matrix or provide structural reinforcement, enhance the adhesion, proliferation, survival, and derivatives of stem cells, hence playing an important role in tissue engineering. The pre-use modification of graphene and its derivative-based materials used in biomedical implementations is crucial for mitigating concerns with “toxicity” and “biosafety,” in addition to the many advantages they provide.

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References

  1. Abbasi H, Antunes M, Velasco JI (2019) Recent advances in carbon-based polymer nanocomposites for electromagnetic interference shielding. Prog Mater Sci 103:319–373

    Article  CAS  Google Scholar 

  2. Bachheti RK, Bachheti A, Husen A (2023) Metal and metal-oxide based nanomaterials (Synthesis, agricultural, biomedical and environmental ınterventions). Springer Nature Singapore Pte Ltd., 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

    Google Scholar 

  3. Bahri M, Gebre SH, Elaguech MA, Dajan FT, Sendeku MG, Tlili C, Wang D (2023) Recent advances in chemical vapour deposition techniques for graphene-based nanoarchitectures: from synthesis to contemporary applications. Coord Chem Rev 475:214910

    Article  CAS  Google Scholar 

  4. Bai RG, Husseini GA (2019) Graphene-based drug delivery systems. Elsevier Inc.

    Google Scholar 

  5. Bedeloğlu A, Taş M (2016) Graphene and ıts production methods. Afyon Kocatepe Univ J Sci Eng 16:544–554

    Google Scholar 

  6. Bekiari V, Karakassides A, Georgitsopoulou S, Kouloumpis A, Gournis D, Georgakilas V (2018) Self-assembly of one-side-functionalized graphene nanosheets in bilayered superstructures for drug delivery. J Mater Sci 53:11167–11175

    Article  CAS  Google Scholar 

  7. Bhanuprakash L, Parasuram S, Varghese S (2019) Experimental investigation on graphene oxides coated carbon fibre/epoxy hybrid composites: mechanical and electrical properties. Compos Sci Technol 179:134–144

    Article  CAS  Google Scholar 

  8. Chawla S, Singh S, Husen A (2023) Smart nanomaterials targeting pathological hypoxia. Springer Nature Singapore Pte Ltd., 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore. https://doi.org/10.1007/978-981-99-1718-1

  9. Das S, Mitra S, Khurana SMP, Debnath N (2013) Nanomaterials for biomedical applications. Front Life Sci 7:90–98

    Article  CAS  Google Scholar 

  10. Dasari BL, Nouri JM, Brabazon D, Naher S (2017) Graphene and derivatives—synthesis techniques, properties and their energy applications. Energy 140:766–778

    Article  CAS  Google Scholar 

  11. Dasari Shareena TP, McShan D, Dasmahapatra AK, Tchounwou PB (2018) A review on graphene-based nanomaterials in biomedical applications and risks in environment and health. Nanomicro Lett 10:1–34

    Google Scholar 

  12. Depan D, Shah J, Misra RDK (2011) Controlled release of drug from folate-decorated and graphene mediated drug delivery system: synthesis, loading efficiency, and drug release response. Mater Sci Eng, C 31:1305–1312

    Article  CAS  Google Scholar 

  13. Foo ME, Gopinath SCB (2017) Feasibility of graphene in biomedical applications. Biomed Pharmacother 94:354–361

    Article  CAS  PubMed  Google Scholar 

  14. Georgakilas V, Tiwari JN, Kemp KC, Perman JA, Bourlinos AB, Kim KS, Zboril R (2016) Noncovalent functionalization of graphene and graphene oxide for energy materials, biosensing, catalytic, and biomedical applications. Chem Rev 116:5464–5519

    Article  CAS  PubMed  Google Scholar 

  15. Husen A, Bachheti RK, Bachheti A (2023) Current trends in green nano-emulsions (Food, agriculture and biomedical sectors). Springer Nature Singapore Pte Ltd., 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

    Google Scholar 

  16. Husen A, Siddiqi KS (2023) Advances in smart nanomaterials and their applications. Elsevier Inc., 50 Hampshire St., 5th Floor, Cambridge, MA 02139, USA

    Google Scholar 

  17. **-Chul K, Madhusudhan A, Husen A (2021) Smart nanomaterials in biomedical applications. Springer Nature Switzerland AG, Gewerbestrasse 11, 6330 Cham, Switzerland. https://doi.org/10.1007/978-3-030-84262-8

  18. Karimi Shervedani R, Mirhosseini H, Samiei Foroushani M, Torabi M, Rahsepar FR, Norouzi-Barough L (2018) Immobilization of methotrexate anticancer drug onto the graphene surface and interaction with calf thymus DNA and 4T1 cancer cells. Bioelectrochemistry 119:1–9

    Article  CAS  PubMed  Google Scholar 

  19. Mabrouk M, Das DB, Salem ZA, Beherei HH (2021) Nanomaterials for biomedical applications: production, characterisations, recent trends and difficulties. Molecules 26:1–27

    Article  Google Scholar 

  20. Madhusudhan A, Purohit SD, Prasad R, Husen A (2023) Functional smart nanomaterials and their theranostics approaches. Springer Nature Singapore Pte Ltd., 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

    Google Scholar 

  21. Mandal AK, Ghorai S, Husen A (2023) Functionalized smart nanomaterials for point-of-care testing. Springer Nature Singapore Pte Ltd., 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

    Google Scholar 

  22. Mcallister MJ, Li J, Adamson DH, Schniepp HC, Abdala AA, Liu J, Herrera-alonso OM, Milius DL, Car R, Prud RK, Aksay IA (2007) Expansion of graphite. Society 19:4396–4404

    Google Scholar 

  23. Perreault F, Fonseca De Faria A, Elimelech M (2015) Environmental applications of graphene-based nanomaterials. Chem Soc Rev 44:5861–5896

    Article  CAS  PubMed  Google Scholar 

  24. Phiri J, Gane P, Maloney TC (2017) General overview of graphene: production, properties and application in polymer composites. Mater Sci Eng B Solid State Mater Adv Technol 215:9–28

    Article  CAS  Google Scholar 

  25. Priya Swetha PD, Manisha H, Sudhakaraprasad K (2018) Graphene and graphene-based materials in biomedical science. Part Part Syst Charact 35:1–29

    Article  Google Scholar 

  26. Pumera M (2010) Graphene-based nanomaterials and their electrochemistry. Chem Soc Rev 39:4146–4157

    Article  CAS  PubMed  Google Scholar 

  27. Schäffel F (2012) The atomic structure of graphene and ıts few-layer counterparts. Graphene: fundamentals and emergent applications 5–59

    Google Scholar 

  28. Sharma G, Nim S, Alle M, Husen A, Kim JC (2022) Nanoparticle-mediated delivery of flavonoids for cancer therapy: prevention and treatment. In: Kim JC, Alle M, Husen A (eds) Smart nanomaterials in biomedical applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-84262-8_3

  29. Shen H, Zhang L, Liu M, Zhang Z (2012) Biomedical applications of graphene. Theranostics 2:283–294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Shin SR, Li YC, Jang HL, Khoshakhlagh P, Akbari M, Nasajpour A, Zhang YS, Tamayol A, Khademhosseini A (2016) Graphene-based materials for tissue engineering. Adv Drug Deliv Rev 105:255–274

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Siddiqi KS, Husen A, Sohrab SS, Osman M (2018) Recent status of nanomaterials fabrication and their potential applications in neurological disease management. Nanoscale Res Lett 13(231):1–17

    Google Scholar 

  32. Solanki A, Shah S, Yin PT, Lee KB (2013) Nanotopography-mediated reverse uptake for siRNA delivery into neural stem cells to enhance neuronal differentiation. Sci Rep 3

    Google Scholar 

  33. Song WL, Gong C, Li H, Cheng XD, Chen M, Yuan X, Chen H, Yang Y, Fang D (2017) Graphene-based sandwich structures for frequency selectable electromagnetic shielding. ACS Appl Mater Interfaces 9:36119–36129

    Article  CAS  PubMed  Google Scholar 

  34. Sontakke AD, Tiwari S, Purkait MK (2023) A comprehensive review on graphene oxide-based nanocarriers: synthesis, functionalization and biomedical applications. FlatChem 38:100484

    Article  CAS  Google Scholar 

  35. Wu SY, An SSA, Hulme J (2015) Current applications of graphene oxide in nanomedicine. Int J Nanomedicine 10:9–24

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Xu S, Zhang L, Wang B, Ruoff RS (2021) Chemical vapor deposition of graphene on thin-metal films. Cell Rep Phys Sci 2:100372

    Article  CAS  Google Scholar 

  37. Yang H, Zheng D, Tang W, Bao X, Cui H (2023) Application of graphene and its derivatives in cementitious materials: an overview. J Build Eng 65:107054

    Google Scholar 

  38. Yang K, Feng L, Liu Z (2016) Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy. Adv Drug Deliv Rev 105:228–241

    Article  CAS  PubMed  Google Scholar 

  39. Yang X, Zhang X, Liu Z, Ma Y, Huang Y, Chen Y (2008) High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. J Phys Chem C 112:17554–17558

    Article  CAS  Google Scholar 

  40. Yapici MK, Alkhidir TE (2017) Intelligent medical garments with graphene-functionalized smart-cloth ECG sensors. Sensors (Switzerland) 17:1–12

    Article  Google Scholar 

  41. Yazıcı M, Tiyek İ, Ersoy MS, Alma MH, Dönmez U, Yıldırım B, Salan T, Karataş Ş, Uruş S, Karteri İ, Yıldız K (2016) Synthesis of graphene oxide (GO) by modified hummer’s methods and its characterization. Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji 4:41–48

    Google Scholar 

  42. Yin PT, Shah S, Chhowalla M, Lee KB (2015) Design, synthesis, and characterization of graphene-nanoparticle hybrid materials for bioapplications. Chem Rev 115:2483–2531

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Yu H, Zhang B, Bulin C, Li R, **ng R (2016) High-efficient synthesis of graphene oxide based on improved hummers method. Sci Rep 6:1–7

    CAS  Google Scholar 

  44. Yu X, Cheng H, Zhang M, Zhao Y, Qu L, Shi G (2017) Graphene-based smart materials. Nat Rev Mater 2

    Google Scholar 

  45. Zaaba NI, Foo KL, Hashim U, Tan SJ, Liu WW, Voon CH (2017) Synthesis of graphene oxide using modified hummers method: solvent influence. Procedia Eng 184:469–477

    Article  CAS  Google Scholar 

  46. Zhang H, Grüner G, Zhao Y (2013) Recent advancements of graphene in biomedicine. J Mater Chem B 1:2542–2567

    Article  CAS  PubMed  Google Scholar 

  47. Zhao H, Ding R, Zhao X, Li Y, Qu L, Pei H, Yildirimer L, Wu Z, Zhang W (2017) Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering. Drug Discov Today 22:1302–1317

    Article  CAS  PubMed  Google Scholar 

  48. Zhen Z, Zhu H (2017) Structure and properties of graphene. Elsevier Inc.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Faculty of Engineering, and Natural Sciences, Bursa Technical University, 16310, Bursa, Türkiye

    Sevgi Kemeç Aslan

  2. Department of Agricultural Biotechnology, Faculty of Agriculture, Iğdır University, 76000, Iğdır, Türkiye

    Kaan Hürkan

Authors
  1. Sevgi Kemeç Aslan
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  2. Kaan Hürkan
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Correspondence to Sevgi Kemeç Aslan .

Editor information

Editors and Affiliations

  1. Department of Environment Science, Graphic Era University, Dehradun, Uttarakhand, India

    Archana (Joshi) Bachheti

  2. Department of Industrial Chemistry, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia

    Rakesh Kumar Bachheti

  3. Department of Biotechnology, Smt. S. S. Patel Nootan Science & Commerce College, Sankalchand Patel University, Visnagar, Gujarat, India

    Azamal Husen

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Kemeç Aslan, S., Hürkan, K. (2024). A Recent Update of Graphene-Based Nanomaterials for Biomedical Applications: Focusing on Drug Delivery and Tissue Engineering. In: Bachheti, A.(., Bachheti, R.K., Husen, A. (eds) Carbon-Based Nanomaterials. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-981-97-0240-4_11

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