Abstract
Magnetic nanoparticle (MNP)-based technologies are now often used in biological systems for therapeutic or diagnostic applications. Recent developments in nanotechnology have led to the creation of MNPs, which are appropriate for biomedical applications. Magnetic nanoparticles are a class of extremely adaptable instruments for cancer therapy because of their innate magnetic characteristics and multifunctional design. For cancer diagnosis, monitoring, and therapy, this category provides a multimodal theranostics platform. In terms of diagnosis, magnetic nanoparticles (MNPs) can be used to increase the sensitivity of the platforms. Magnetic nanoparticles (MNPs) with high magnetic moments and surface-to-volume ratios are attractive for targeted medication delivery and cancer treatment. In this chapter, recent developments in the application of MNPs for biosensing, drug delivery control, and therapy of cancer will be provided. The field’s challenges and potential opportunities for using MNPs to enhance their properties will be considered.
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References
Singh AK (2016) Experimental methodologies for the characterization of nanoparticles. In: Engineered nanoparticles. Elsevier, Amsterdam, pp 125–170
Qiao K, Xu L, Tang J, Wang Q, Lim KS, Hooper G, Woodfield TBF, Liu G, Tian K, Zhang W et al (2022) The advances in nanomedicine for bone and cartilage repair. J Nanobiotechnol 20:141. https://doi.org/10.1186/s12951-022-01342-8
Joudeh N, Linke D (2022) Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. J Nanobiotechnol 20:262. https://doi.org/10.1186/s12951-022-01477-8
Cheng T-M, Chu H-Y, Huang H-M, Li Z-L, Chen C-Y, Shih Y-J, Whang-Peng J, Cheng RH, Mo J-K, Lin H-Y et al (2022) Toxicologic concerns with current medical nanoparticles. Int J Mol Sci 23:7597. https://doi.org/10.3390/ijms23147597
Altammar KA (2023) A review on nanoparticles: characteristics, synthesis, applications, and challenges. Front Microbiol 14:1155622. https://doi.org/10.3389/fmicb.2023.1155622
Madkour LH (2023) Eco-friendly green biosynthesized metallic nanoparticles and biotechnological applications in pharmaceuticals sciences. J Mater Sci Eng B 13:1–69. https://doi.org/10.17265/2161-6221/2023.1-3.001
Yang Y, Chawla A, Zhang J, Esa A, Jang HL, Khademhosseini A (2019) Applications of nanotechnology for regenerative medicine; healing tissues at the nanoscale. In: Principles of regenerative medicine. Elsevier, Amsterdam, pp 485–504
Al-Anazi A (2022) Iron-based magnetic nanomaterials in environmental and energy applications: a short review. Curr Opin Chem Eng 36:100794. https://doi.org/10.1016/j.coche.2022.100794
Díez AG, Rincón-Iglesias M, Lanceros-Méndez S, Reguera J, Lizundia E (2022) Multicomponent magnetic nanoparticle engineering: the role of structure-property relationship in advanced applications. Mater Today Chem 26:101220. https://doi.org/10.1016/j.mtchem.2022.101220
Ali A, Shah T, Ullah R, Zhou P, Guo M, Ovais M, Tan Z, Rui Y (2021) Review on recent progress in magnetic nanoparticles: synthesis, characterization, and diverse applications. Front Chem 9:629054. https://doi.org/10.3389/fchem.2021.629054
Mittal A, Roy I, Gandhi S (2022) Magnetic nanoparticles: an overview for biomedical applications. Magnetochemistry 8:107. https://doi.org/10.3390/magnetochemistry8090107
Gul S, Khan SB, Rehman IU, Khan MA, Khan MI (2019) A comprehensive review of magnetic nanomaterials modern day theranostics. Front Mater 6:179. https://doi.org/10.3389/fmats.2019.00179
Petrov KD, Chubarov AS (2022) Magnetite nanoparticles for biomedical applications. Encyclopedia 2:1811–1828. https://doi.org/10.3390/encyclopedia2040125
Dudchenko N, Pawar S, Perelshtein I, Fixler D (2022) Magnetite nanoparticles: synthesis and applications in optics and nanophotonics. Materials (Basel) 15:2601. https://doi.org/10.3390/ma15072601
Shukla S, Khan R, Daverey A (2021) Synthesis and characterization of magnetic nanoparticles, and their applications in wastewater treatment: a review. Environ Technol Innov 24:101924. https://doi.org/10.1016/j.eti.2021.101924
García-Merino B, Bringas E, Ortiz I (2022) Synthesis and applications of surface-modified magnetic nanoparticles: progress and future prospects. Rev Chem Eng 38:821–842. https://doi.org/10.1515/revce-2020-0072
Zhu N, Ji H, Yu P, Niu J, Farooq M, Akram M, Udego I, Li H, Niu X (2018) Surface modification of magnetic iron oxide nanoparticles. Nanomaterials 8:810. https://doi.org/10.3390/nano8100810
Ling W, Wang M, **ong C, **e D, Chen Q, Chu X, Qiu X, Li Y, **ao X (2019) Synthesis, surface modification, and applications of magnetic iron oxide nanoparticles. J Mater Res 34:1828–1844. https://doi.org/10.1557/jmr.2019.129
Natarajan S, Harini K, Gajula GP, Sarmento B, Neves-Petersen MT, Thiagarajan V (2019) Multifunctional magnetic iron oxide nanoparticles: diverse synthetic approaches, surface modifications, cytotoxicity towards biomedical and industrial applications. BMC Mater 1:2. https://doi.org/10.1186/s42833-019-0002-6
Kudr J, Haddad Y, Richtera L, Heger Z, Cernak M, Adam V, Zitka O (2017) Magnetic nanoparticles: from design and synthesis to real world applications. Nanomaterials 7:243. https://doi.org/10.3390/nano7090243
Khizar S, Ahmad NM, Zine N, Jaffrezic-Renault N, Errachid-el-salhi A, Elaissari A (2021) Magnetic nanoparticles: from synthesis to theranostic applications. ACS Appl Nano Mater 4:4284–4306. https://doi.org/10.1021/acsanm.1c00852
Zhao S, Yu X, Qian Y, Chen W, Shen J (2020) Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics. Theranostics 10:6278–6309. https://doi.org/10.7150/thno.42564
Ferreira M, Sousa J, Pais A, Vitorino C (2020) The role of magnetic nanoparticles in cancer nanotheranostics. Materials (Basel) 13:266. https://doi.org/10.3390/ma13020266
Yigit MV, Moore A, Medarova Z (2012) Magnetic nanoparticles for cancer diagnosis and therapy. Pharm Res 29:1180–1188. https://doi.org/10.1007/s11095-012-0679-7
Sim S, Wong N (2021) Nanotechnology and its use in imaging and drug delivery (review). Biomed Rep 14:42. https://doi.org/10.3892/br.2021.1418
Joseph TM, Kar Mahapatra D, Esmaeili A, Piszczyk Ł, Hasanin MS, Kattali M, Haponiuk J, Thomas S (2023) Nanoparticles: taking a unique position in medicine. Nanomaterials 13:574. https://doi.org/10.3390/nano13030574
Lima-Tenório MK, Gómez Pineda EA, Ahmad NM, Fessi H, Elaissari A (2015) Magnetic nanoparticles: in vivo cancer diagnosis and therapy. Int J Pharm 493:313–327. https://doi.org/10.1016/j.ijpharm.2015.07.059
Jat SK, Gandhi HA, Bhattacharya J, Sharma MK (2021) Magnetic nanoparticles: an emerging nano-based tool to fight against viral infections. Mater Adv 2:4479–4496. https://doi.org/10.1039/D1MA00240F
Farzin A, Etesami SA, Quint J, Memic A, Tamayol A (2020) Magnetic nanoparticles in cancer therapy and diagnosis. Adv Healthc Mater 9:1901058. https://doi.org/10.1002/adhm.201901058
Alromi D, Madani S, Seifalian A (2021) Emerging application of magnetic nanoparticles for diagnosis and treatment of cancer. Polymers (Basel) 13:4146. https://doi.org/10.3390/polym13234146
Revia RA, Zhang M (2016) Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. Mater Today 19:157–168. https://doi.org/10.1016/j.mattod.2015.08.022
Cyran CC, Paprottka PM, Eisenblätter M, Clevert DA, Rist C, Nikolaou K, Lauber K, Wenz F, Hausmann D, Reiser MF et al (2014) Visualization, imaging and new preclinical diagnostics in radiation oncology. Radiat Oncol 9:3. https://doi.org/10.1186/1748-717X-9-3
Stephen ZR, Kievit FM, Zhang M (2011) Magnetite nanoparticles for medical MR imaging. Mater Today 14:330–338. https://doi.org/10.1016/S1369-7021(11)70163-8
Jeon M, Halbert MV, Stephen ZR, Zhang M (2021) Iron oxide nanoparticles as T 1 contrast agents for magnetic resonance imaging: fundamentals, challenges, applications, and prospectives. Adv Mater 33:1906539. https://doi.org/10.1002/adma.201906539
Zhao Z, Li M, Zeng J, Huo L, Liu K, Wei R, Ni K, Gao J (2022) Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging. Bioact Mater 12:214–245. https://doi.org/10.1016/j.bioactmat.2021.10.014
Avasthi A, Caro C, Pozo-Torres E, Leal MP, García-Martín ML (2020) Magnetic nanoparticles as MRI contrast agents. Top Curr Chem 378:40. https://doi.org/10.1007/s41061-020-00302-w
Jaswal N, Justa P, Kumar H, Deepshikha, Krishna, Pani B, Kumar P (2023) Biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONS) as a theranostic agent. In: Iron ores and iron oxide [Working Title]. IntechOpen, London
Suciu M, Ionescu CM, Ciorita A, Tripon SC, Nica D, Al-Salami H, Barbu-Tudoran L (2020) Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements. Beilstein J Nanotechnol 11:1092–1109. https://doi.org/10.3762/bjnano.11.94
Gayathri T, Sundaram NM, Kumar RA (2015) Gadolinium oxide nanoparticles for magnetic resonance imaging and cancer theranostics. J Bionanosci 9:409–423. https://doi.org/10.1166/jbns.2015.1325
Hifumi H, Yamaoka S, Tanimoto A, Citterio D, Suzuki K (2006) Gadolinium-based hybrid nanoparticles as a positive MR contrast agent. J Am Chem Soc 128:15090–15091. https://doi.org/10.1021/ja066442d
Caspani S, Magalhães R, Araújo JP, Sousa CT (2020) Magnetic nanomaterials as contrast agents for MRI. Materials (Basel) 13:2586. https://doi.org/10.3390/ma13112586
Zhou M, Singhana B, Liu Y, Huang Q, Mitcham T, Wallace MJ, Stafford RJ, Bouchard RR, Melancon MP (2015) Photoacoustic- and magnetic resonance-guided photothermal therapy and tumor vasculature visualization using theranostic magnetic gold nanoshells. J Biomed Nanotechnol 11:1442–1450. https://doi.org/10.1166/jbn.2015.2089
Farinha P, Coelho JMP, Reis CP, Gaspar MM (2021) A comprehensive updated review on magnetic nanoparticles in diagnostics. Nanomaterials 11:3432. https://doi.org/10.3390/nano11123432
Hosu O, Tertis M, Cristea C (2019) Implication of magnetic nanoparticles in cancer detection, screening and treatment. Magnetochemistry 5:55. https://doi.org/10.3390/magnetochemistry5040055
Onishi T, Mihara K, Matsuda S, Sakamoto S, Kuwahata A, Sekino M, Kusakabe M, Handa H, Kitagawa Y (2022) Application of magnetic nanoparticles for rapid detection and in situ diagnosis in clinical oncology. Cancers (Basel) 14:364. https://doi.org/10.3390/cancers14020364
Kavetskyy T, Alipour M, Smutok O, Mushynska O, Kiv A, Fink D, Farshchi F, Ahmadian E, Hasanzadeh M (2021) Magneto-immunoassay of cancer biomarkers: recent progress and challenges in biomedical analysis. Microchem J 167:106320. https://doi.org/10.1016/j.microc.2021.106320
Materón EM, Miyazaki CM, Carr O, Joshi N, Picciani PHS, Dalmaschio CJ, Davis F, Shimizu FM (2021) Magnetic nanoparticles in biomedical applications: a review. Appl Surf Sci Adv 6:100163. https://doi.org/10.1016/j.apsadv.2021.100163
Afzal O, Altamimi ASA, Nadeem MS, Alzarea SI, Almalki WH, Tariq A, Mubeen B, Murtaza BN, Iftikhar S, Riaz N et al (2022) Nanoparticles in drug delivery: from history to therapeutic applications. Nanomaterials 12:4494. https://doi.org/10.3390/nano12244494
Lorscheider M, Gaudin A, Nakhlé J, Veiman K-L, Richard J, Chassaing C (2021) Challenges and opportunities in the delivery of cancer therapeutics: update on recent progress. Ther Deliv 12:55–76. https://doi.org/10.4155/tde-2020-0079
Xu Q, Li C, Chen Y, Zhang Y, Lu B (2021) Metal-organic framework-based intelligent drug delivery systems for cancer theranostic: a review. Front Mater Sci 15:374–390. https://doi.org/10.1007/s11706-021-0568-2
Edis Z, Wang J, Waqas MK, Ijaz M, Ijaz M (2021) Nanocarriers-mediated drug delivery systems for anticancer agents: an overview and perspectives. Int J Nanomedicine 16:1313–1330. https://doi.org/10.2147/IJN.S289443
Liu C, Wu K, Li J, Mu X, Gao H, Xu X (2023) Nanoparticle-mediated therapeutic management in cholangiocarcinoma drug targeting: current progress and future prospects. Biomed Pharmacother 158:114135. https://doi.org/10.1016/j.biopha.2022.114135
Chenthamara D, Subramaniam S, Ramakrishnan SG, Krishnaswamy S, Essa MM, Lin F-H, Qoronfleh MW (2019) Therapeutic efficacy of nanoparticles and routes of administration. Biomater Res 23:20. https://doi.org/10.1186/s40824-019-0166-x
Cai M, Zeng Y, Liu M, You L, Huang H, Hao Y, Yin X, Qu C, Ni J, Dong X (1945) Construction of a multifunctional nano-scale metal-organic framework-based drug delivery system for targeted cancer therapy. Pharmaceutics 2021:13. https://doi.org/10.3390/pharmaceutics13111945
Vodyashkin AA, Sergorodceva AV, Kezimana P, Stanishevskiy YM (2023) Metal-organic framework (MOF)—a universal material for biomedicine. Int J Mol Sci 24:7819. https://doi.org/10.3390/ijms24097819
Mishra S, Fulden Ulucan-Karnak CİK (2023) Recent advancements in metal-organic frameworks for drug delivery. In: Advanced functional metal-organic frameworks, pp 1–318. https://doi.org/10.1201/9781003252061
**ang Z, Qi Y, Lu Y, Hu Z, Wang X, Jia W, Hu J, Ji J, Lu W (2020) MOF-derived novel porous Fe 3 O 4 @C nanocomposites as smart nanomedical platforms for combined cancer therapy: magnetic-triggered synergistic hyperthermia and chemotherapy. J Mater Chem B 8:8671–8683. https://doi.org/10.1039/D0TB01021A
Lodhi MS, Khalid F, Khan MT, Samra ZQ, Muhammad S, Zhang Y-J, Mou K (2022) A novel method of magnetic nanoparticles functionalized with anti-folate receptor antibody and methotrexate for antibody mediated targeted drug delivery. Molecules 27:261. https://doi.org/10.3390/molecules27010261
Rezaeian M, Soltani M, Naseri Karimvand A, Raahemifar K (2022) Mathematical modeling of targeted drug delivery using magnetic nanoparticles during intraperitoneal chemotherapy. Pharmaceutics 14:324. https://doi.org/10.3390/pharmaceutics14020324
Li X, Li W, Wang M, Liao Z (2021) Magnetic nanoparticles for cancer theranostics: advances and prospects. J Control Release 335:437–448. https://doi.org/10.1016/j.jconrel.2021.05.042
Stueber DD, Villanova J, Aponte I, **ao Z, Colvin VL (2021) Magnetic nanoparticles in biology and medicine: past, present, and future trends. Pharmaceutics 13:943. https://doi.org/10.3390/pharmaceutics13070943
**ong J, Wu M, Chen J, Liu Y, Chen Y, Fan G, Liu Y, Cheng J, Wang Z, Wang S et al (2021) Cancer-erythrocyte hybrid membrane-camouflaged magnetic nanoparticles with enhanced photothermal-immunotherapy for ovarian cancer. ACS Nano 15:19756–19770. https://doi.org/10.1021/acsnano.1c07180
Zhang F, Lu G, Wen X, Li F, Ji X, Li Q, Wu M, Cheng Q, Yu Y, Tang J et al (2020) Magnetic nanoparticles coated with polyphenols for Spatio-temporally controlled cancer photothermal/immunotherapy. J Control Release 326:131–139. https://doi.org/10.1016/j.jconrel.2020.06.015
Han H, Hou Y, Chen X, Zhang P, Kang M, ** Q, Ji J, Gao M (2020) Metformin-induced stromal depletion to enhance the penetration of gemcitabine-loaded magnetic nanoparticles for pancreatic cancer targeted therapy. J Am Chem Soc 142:4944–4954. https://doi.org/10.1021/jacs.0c00650
Oliveira RR, Cintra ER, Sousa-Junior AA, Moreira LC, da Silva ACG, de Souza ALR, Valadares MC, Carrião MS, Bakuzis AF, Lima EM (2023) Paclitaxel-loaded lipid-coated magnetic nanoparticles for dual chemo-magnetic hyperthermia therapy of melanoma. Pharmaceutics 15:818. https://doi.org/10.3390/pharmaceutics15030818
Hasani M, Jafari S, Akbari Javar H, Abdollahi H, Rashidzadeh H (2023) Cell-penetrating peptidic GRP78 ligand-conjugated iron oxide magnetic nanoparticles for tumor-targeted doxorubicin delivery and imaging. ACS Appl Bio Mater 6:1019–1031. https://doi.org/10.1021/acsabm.2c00897
Yola ML, Atar N, Özcan N (2021) A novel electrochemical lung cancer biomarker cytokeratin 19 fragment antigen 21-1 immunosensor based on Si 3 N 4/MoS 2 incorporated MWCNTs and core–shell type magnetic nanoparticles. Nanoscale 13:4660–4669. https://doi.org/10.1039/D1NR00244A
Jasemi A, Kamyab Moghadas B, Khandan A, Saber-Samandari S (2022) A porous calcium-zirconia scaffolds composed of magnetic nanoparticles for bone cancer treatment: fabrication, characterization and FEM analysis. Ceram Int 48:1314–1325. https://doi.org/10.1016/j.ceramint.2021.09.216
Dorjsuren B, Chaurasiya B, Ye Z, Liu Y, Li W, Wang C, Shi D, Evans CE, Webster TJ, Shen Y (2020) Cetuximab-coated thermo-sensitive liposomes loaded with magnetic nanoparticles and doxorubicin for targeted EGFR-expressing breast cancer combined therapy. Int J Nanomedicine 15:8201–8215. https://doi.org/10.2147/IJN.S261671
Mohaghegh S, Tarighatnia A, Omidi Y, Barar J, Aghanejad A, Adibkia K (2022) Multifunctional magnetic nanoparticles for MRI-guided co-delivery of Erlotinib and L-Asparaginase to ovarian cancer. J Microencapsul 39:394–408. https://doi.org/10.1080/02652048.2022.2094487
Farmanbar N, Mohseni S, Darroudi M (2022) Green synthesis of chitosan-coated magnetic nanoparticles for drug delivery of Oxaliplatin and Irinotecan against colorectal cancer cells. Polym Bull 79:10595–10613. https://doi.org/10.1007/s00289-021-04066-1
Chen H-A, Lu Y-J, Dash BS, Chao Y-K, Chen J-P (2023) Hyaluronic acid-modified cisplatin-encapsulated poly(lactic-co-glycolic acid) magnetic nanoparticles for dual-targeted NIR-responsive chemo-Photothermal combination cancer therapy. Pharmaceutics 15:290. https://doi.org/10.3390/pharmaceutics15010290
Ünak P, Yasakçı V, Tutun E, Karatay KB, Walczak R, Wawrowicz K, Żelechowska-Matysiak K, Majkowska-Pilip A, Bilewicz A (2023) Multimodal Radiobioconjugates of magnetic nanoparticles Labeled with 44Sc and 47Sc for Theranostic application. Pharmaceutics 15:850. https://doi.org/10.3390/pharmaceutics15030850
Xue F, Zhu S, Tian Q, Qin R, Wang Z, Huang G, Yang S (2023) Macrophage-mediated delivery of magnetic nanoparticles for enhanced magnetic resonance imaging and magnetothermal therapy of solid tumors. J Colloid Interface Sci 629:554–562. https://doi.org/10.1016/j.jcis.2022.08.186
Shaw SK, Sharma A, Kailashiya J, Gupta SK, Meena SS, Dash D, Maiti P, Prasad NK (2023) Mesoporous Fe3O4 nanoparticle: a prospective nano heat generator for thermo-therapeutic cancer treatment modality. J Magn Magn Mater 578:170817. https://doi.org/10.1016/j.jmmm.2023.170817
Zhu H, Zhang L, Kou F, Zhao J, Lei J, He J (2024) Targeted therapeutic effects of oral magnetically driven pectin nanoparticles containing chlorogenic acid on colon cancer. Particuology 84:53–59. https://doi.org/10.1016/j.partic.2023.02.021
Cao Y, Zhang S, Ma M, Zhang Y (2022) Fluorinated PEG-PEI coated magnetic nanoparticles for SiRNA delivery and CXCR4 knockdown. Nanomaterials 12:1692. https://doi.org/10.3390/nano12101692
Benyettou F, Das G, Nair AR, Prakasam T, Shinde DB, Sharma SK, Whelan J, Lalatonne Y, Traboulsi H, Pasricha R et al (2020) Covalent organic framework embedded with magnetic nanoparticles for MRI and chemo-thermotherapy. J Am Chem Soc 142:18782–18794. https://doi.org/10.1021/jacs.0c05381
Chen H, Luo D, Shang B, Cao J, Wei J, Chen Q, Chen J (2020) Immunoassay-type biosensor based on magnetic nanoparticle capture and the fluorescence signal formed by horseradish peroxidase catalysis for tumor-related exosome determination. Microchim Acta 187:282. https://doi.org/10.1007/s00604-020-04275-x
Yektaniroumand Digehsaraei S, Salouti M, Amini B, Mahmazi S, Kalantari M, Kazemizadeh A, Mehrvand J (2021) Develo** a fluorescence immunosensor for detection of HER2-positive breast cancer based on graphene and magnetic nanoparticles. Microchem J 167:106300. https://doi.org/10.1016/j.microc.2021.106300
Esmaeili Y, Khavani M, Bigham A, Sanati A, Bidram E, Shariati L, Zarrabi A, Jolfaie NA, Rafienia M (2022) Mesoporous silica@chitosan@gold nanoparticles as “on/off” optical biosensor and PH-sensitive theranostic platform against cancer. Int J Biol Macromol 202:241–255. https://doi.org/10.1016/j.ijbiomac.2022.01.063
Tiwari H, Rai N, Singh S, Gupta P, Verma A, Singh AK, Kajal, Salvi P, Singh SK, Gautam V (2023) Recent advances in nanomaterials-based targeted drug delivery for preclinical cancer diagnosis and therapeutics. Bioengineering 10:760. https://doi.org/10.3390/bioengineering10070760
Baranwal J, Barse B, Di Petrillo A, Gatto G, Pilia L, Kumar A (2023) Nanoparticles in cancer diagnosis and treatment. Materials (Basel) 16:5354. https://doi.org/10.3390/ma16155354
Umapathy VR, Natarajan PM, Swamikannu B (2023) Review of the role of nanotechnology in overcoming the challenges faced in oral cancer diagnosis and treatment. Molecules 28:5395. https://doi.org/10.3390/molecules28145395
Khursheed R, Dua K, Vishwas S, Gulati M, Jha NK, Aldhafeeri GM, Alanazi FG, Goh BH, Gupta G, Paudel KR et al (2022) Biomedical applications of metallic nanoparticles in cancer: current status and future perspectives. Biomed Pharmacother 150:112951. https://doi.org/10.1016/j.biopha.2022.112951
Flores-Rojas GG, López-Saucedo F, Vera-Graziano R, Mendizabal E, Bucio E (2022) Magnetic nanoparticles for medical applications: updated review. Macromolecules 2:374–390. https://doi.org/10.3390/macromol2030024
Vangijzegem T, Lecomte V, Ternad I, Van Leuven L, Muller RN, Stanicki D, Laurent S (2023) Superparamagnetic iron oxide nanoparticles (SPION): from fundamentals to state-of-the-art innovative applications for cancer therapy. Pharmaceutics 15:236. https://doi.org/10.3390/pharmaceutics15010236
Abbasi R, Shineh G, Mobaraki M, Doughty S, Tayebi L (2023) Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review. J Nanopart Res 25:43. https://doi.org/10.1007/s11051-023-05690-w
Dash S, Das T, Patel P, Panda PK, Suar M, Verma SK (2022) Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases. J Nanobiotechnol 20:393. https://doi.org/10.1186/s12951-022-01595-3
Ramburrun P, Khan RA, Choonara YE (2022) Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications. Nanotechnol Rev 11:1802–1826. https://doi.org/10.1515/ntrev-2022-0106
Stillman NR, Kovacevic M, Balaz I, Hauert S (2020) In silico modelling of cancer nanomedicine, across scales and transport barriers. NPJ Comput Mater 6:92. https://doi.org/10.1038/s41524-020-00366-8
Koksharov YA, Gubin SP, Taranov IV, Khomutov GB, Gulyaev YV (2022) Magnetic nanoparticles in medicine: progress, problems, and advances. J Commun Technol Electron 67:101–116. https://doi.org/10.1134/S1064226922020073
Włodarczyk A, Gorgoń S, Radoń A, Bajdak-Rusinek K (2022) Magnetite nanoparticles in magnetic hyperthermia and cancer therapies: challenges and perspectives. Nanomaterials 12:1807. https://doi.org/10.3390/nano12111807
Spoială A, Ilie C-I, Motelica L, Ficai D, Semenescu A, Oprea O-C, Ficai A (2023) Smart magnetic drug delivery systems for the treatment of cancer. Nanomaterials 13:876. https://doi.org/10.3390/nano13050876
Govindan B, Sabri MA, Hai A, Banat F, Haija MA (2023) A review of advanced multifunctional magnetic nanostructures for cancer diagnosis and therapy integrated into an artificial intelligence approach. Pharmaceutics 15:868. https://doi.org/10.3390/pharmaceutics15030868
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Kuru, C.İ., Ulucan-Karnak, F., Akgöl, S. (2024). Therapeutic and Diagnostic Uses of Magnetic Nanoparticles in Cancer. In: Javed, R., Chen, JT., Khalil, A.T. (eds) Nanomaterials for Biomedical and Bioengineering Applications. Springer, Singapore. https://doi.org/10.1007/978-981-97-0221-3_4
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