Challenges and Materials in Artificial Organ Manufacturing

  • Conference paper
  • First Online:
Advances in Engineering Materials

Abstract

Additive manufacturing (AM), is also known as rapid prototy**, is considered as a revolution in field of manufacturing and fabrications and boosted the development in biomedical fabrication. The 3D printing technique is mostly utilized in the field of medical for the manufacturing of medical equipment and surgical equipment, especially 3D biomedical printing which means 3D printing of substance which are biologically compatible to human body, blood and cells in the field of tissue fabrications. The main aim of tissue fabrications and engineering is to produce the artificial organ which is functional and viable. To fulfill this objective, investigation of various manufacturing techniques and materials is required. The process is difficult as it includes multiple aspects of human physiology, like types of multiple cell culturing, vasculature, nerve innervation, and interactions with nearby cells. This paper objective is to find the suitable material, is difficult task and, need in-depth focus on why it is difficult & what are the factors influencing the negative role of effective utilization of 3D printing tissue engineering. Also, this paper focuses on comparative study of materials in economic perspective human organ manufacturing. At the end, the conclusion elaborates about the applications and challenges of additive manufacturing in medical field and the alternative materials for organ tissue manufacturing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Wang, X., Ao, Q., Tian, X., Fan, J., Tong, H., Hou, W., & Bai, S. (2017). Gelatin-Based hydrogels for organ 3D bioprinting. Polymers, 9(12), 401.

    Article  Google Scholar 

  2. Vienken, J. (2002). Polymers in nephrology characteristics and needs. The International Journal of Artificial Organs, *(5), 470–479. https://doi.org/10.1177/039139880202500518

  3. Nahmias, Y., Arneja, A., Tower, T. T., Renn, M. J., & Odde, D. J. (2005). Cell patterning on biological gels via cell spraying through a mask. Tissue Engineering, 11(5–6), 701–708. https://doi.org/10.1089/ten.2005.11.701.

    Article  Google Scholar 

  4. Wang, X., Yan, Y., & Zhang, R. (2007). Rapid prototy** as a tool for manufacturing bioartificial livers. Trends in Biotechnology, 25(11), 505–513. https://doi.org/10.1016/j.tibtech.2007.08.010.

    Article  Google Scholar 

  5. Li, M. G., Tian, X. Y., & Chen, X. B. (2009). A brief review of dispensing-based rapid prototy** techniques in tissue scaffold fabrication: The role of modelling on scaffold properties prediction. Biofabrication, 1(3), 032001. https://doi.org/10.1088/1758-5082/1/3/032001.

    Article  Google Scholar 

  6. Wang, X., Yan, Y., & Zhang, R. (2010). Recent trends and challenges in complex organ manufacturing. Tissue Engineering Part B: Reviews, 16(2), 189–197.

    Article  Google Scholar 

  7. Chmielewski, A. G. (2010). Chitosan and radiation chemistry. Radiation Physics and Chemistry, 79(3), 272–275. https://doi.org/10.1016/j.radphyschem.2009.11.002.

    Article  Google Scholar 

  8. Kalita, S. J. (2010). Rapid prototy** in biomedical engineering: structural intricacies of biological materials. Bio-integration of Medical Implant Materials, 349–397.

    Google Scholar 

  9. Rath, S. N., Pryymachuk, G., Bleiziffer, O. A., Lam, C. X. F., Arkudas, A., & Ho, S. T. B. (2011). Hyaluronan-based heparin-incorporated hydrogels for the generation of axially vascularized bioartificial bone tissues: In vitro and in vivo evaluation in a PLDLLA–TCP–PCL-composite system. Journal of Materials Science: Materials in Medicine, 22(5), 1279–1291.

    Google Scholar 

  10. Guvendiren, M., Lu, H. D., & Burdick, J. A. (2012). Shear-thinning hydrogels for biomedical applications. Soft Matter, 8(2), 260–272.

    Google Scholar 

  11. Wang, X. (2012). Intelligent freeform manufacturing of complex organs. Artificial Organs, 36(11), 951–959. https://doi.org/10.1111/j.1525-1594.2012.01499.x.

    Article  Google Scholar 

  12. Marga, F., Jakab, K., Khatiwala, C., Shepherd, B., Dorfman, S., & Hubbard, B. (2012). Toward engineering functional organ modules by additive manufacturing. Biofabrication, 4(2), 022001.

    Article  Google Scholar 

  13. IKADA, Y. (2001). Biocompatibility of hydrogels. Gels Handbook, 388–407.

    Google Scholar 

  14. Zhu, J., Zhang, Y., Xu, N., Wang, L., **ang, X., & Zhu, X. (2013). The preparation of PLL–GRGDS modified PTSG copolymer scaffolds and their effects on manufacturing artificial salivary gland. Journal of Biomaterials Science, Polymer Edition, 24(15), 1721–1739.

    Article  Google Scholar 

  15. Ahmed, E. M. (2015). Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research, 6(2), 105–121.

    Article  Google Scholar 

  16. Murphy, S. V., & Atala, A. (2014). 3D bioprinting of tissues and organs. Nature Biotechnology, 32(8), 773–785. https://doi.org/10.1038/nbt.2958.

    Article  Google Scholar 

  17. Li, Jianyu, Suo, Zhigang, & Vlassak, Joost J. (2014). Stiff, strong, and tough hydrogels with good chemical stability. Journal of Materials Chemistry B, 2(39), 6708–6713.

    Article  Google Scholar 

  18. Ahn, S. H., Lee, J., Park, S. A., & Kim, W. D. (2016). Three-dimensional bioprinting equipment technologies for tissue engineering and regenerative medicine. Tissue Engineering and Regenerative Medicine, 13(6), 663–676.

    Article  Google Scholar 

  19. Park, S.-H., Jung, C. S., & Min, B.-H. (2016). Advances in three-dimensional bioprinting for hard tissue engineering. Tissue Engineering and Regenerative Medicine, 13(6), 622–635.

    Article  Google Scholar 

  20. Agarwala, S. (2016). A perspective on 3D bioprinting technology: Present and future. Journal of Engineering and Applied Science, 9(4), 931.

    Google Scholar 

  21. Zadpoor, A. A., & Malda, J. (2016). Additive manufacturing of biomaterials, tissues, and organs. Annals of Biomedical Engineering, 45(1), 1–11.

    Article  Google Scholar 

  22. Zhang, Y. S., Yue, K., Aleman, J., Mollazadeh-Moghaddam, K., Bakht, S. M., & Yang, J. (2016). 3D bioprinting for tissue and organ fabrication. Annals of Biomedical Engineering, 45(1), 148–163.

    Article  Google Scholar 

  23. Naseer, S. M., Manbachi, A., Samandari, M., Walch, P., Gao, Y., & Zhang, Y. S. (2017). Surface acoustic waves induced micropatterning of cells in gelatin methacryloyl (GelMA) hydrogels. Biofabrication, 9(1), 015020. https://doi.org/10.1088/1758-5090/aa585e.

    Article  Google Scholar 

  24. Ratheesh, G., Venugopal, J. R., Chinappan, A., Ezhilarasu, H., Sadiq, A., & Ramakrishna, S. (2017). 3D fabrication of polymeric scaffolds for regenerative therapy. ACS Biomaterials Science & Engineering, 3(7), 1175–1194.

    Article  Google Scholar 

  25. Wu, D., Yu, Y., Tan, J., Huang, L., Luo, B., Lu, L. et al. (2018). 3D bioprinting of gellan gum and poly (ethylene glycol) diacrylate based hydrogels to produce human-scale constructs with high-fidelity. Materials & Design.

    Google Scholar 

  26. Saroia, J., Yanen, W., Wei, Q., Zhang, K., Lu, T., & Zhang, B. (2018). A review on biocompatibility nature of hydrogels with 3D printing techniques, tissue engineering application and its future prospective. Bio-Design and Manufacturing. https://doi.org/10.1007/s42242-018-0029-7.

    Article  Google Scholar 

  27. Gupta, S., Bissoyi, A., & Bit, A. (2018). A review on 3D printable techniques for tissue engineering. BioNanoScience.

    Google Scholar 

  28. Holzmeister, I., Schamel, M., Groll, J., Gbureck, U., & Vorndran, E. (2018). Artificial inorganic biohybrids: The functional combination of microorganisms and cells with inorganic materials. Acta Biomaterialia, 74, 17–35.

    Article  Google Scholar 

  29. Macko, M., Szczepański, Z., Mikołajewski, D., Nowak, J., Mikołajewska, E., & Furtak, J. (2019). CAE/FDM methods for design and manufacture artificial organs for exercises purposes. Current Topics in Behavioral Neurosciences, 462–469.

    Google Scholar 

  30. Landers, R., & Mulhaupt, R. (2000). Desktop manufacturing of complex objects, prototypes and biomedical scaffolds utilizing computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers. Macromolecular Materials and Engineering, 282, 17–21.

    Article  Google Scholar 

  31. Deliormanlı, A. M. (2019). Direct Write Assembly of Graphene/Poly(ε-Caprolactone) Composite Scaffolds and Evaluation of Their Biological Performance Using Mouse Bone Marrow Mesenchymal Stem Cells. Applied Biochemistry and Biotechnology.

    Google Scholar 

  32. Wenger R. & Giraud M.(2018). 3D Printing Applied to Tissue-Engineered Vascular Grafts. Applied Sciences. https://doi.org/10.3390/app8122631.

  33. Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2019). Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials, 119536.

    Google Scholar 

  34. Kou, G., Ergu, D., Chen, Y., & Lin, C. (2016). Pairwise comparison matrix in multiple criteria decision making. Technological and Economic Development of Economy, 22(5), 738–765.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sumit Budhiraja .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Budhiraja, S., Ashok, P.P., Mathiyazhagan, K. (2021). Challenges and Materials in Artificial Organ Manufacturing. In: Sharma, B.P., Rao, G.S., Gupta, S., Gupta, P., Prasad, A. (eds) Advances in Engineering Materials . Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-33-6029-7_59

Download citation

  • DOI: https://doi.org/10.1007/978-981-33-6029-7_59

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-33-6028-0

  • Online ISBN: 978-981-33-6029-7

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Navigation