Abstract
During last decades, many strategies have been developed and made fast progress in morphology control of amphiphilic assemblies. However, it is still necessary to develop novel strategies to prepare customized assemblies, especially in drug delivery systems. Frame-guided assembly (FGA) is a recently developed strategy to construct assemblies with programmed geometries and dimensions under identical surrounding conditions, which is inspired by the cytoskeletal-membrane protein-lipid bilayer structures. To direct the nondirectional amphiphilic assembly, some leading hydrophobic groups (LHGs) must be introduced onto a frame with designed morphology. The LHGs should be distributed in a discontinuous manner along the frame and outline the fringe of the designed structures, which will further guide the assembly of the amphiphiles to fill in the gaps between LHGs. Therefore, the shape and size of the assemblies would accord with the frame. Since the FGA has been developed in 2014, different frames have been applied to guide the multiple types of amphiphiles, among which, DNA nanostructures have been demonstrated with excellent addressability and programmability to prepare FGA vesicles. Herein, we have provided a comprehensive introduction of the development of FGA. Both inorganic frames and DNA nanostructure frames have been discussed. Furthermore, the development of the DNA nanotechnology has also been introduced in detail, which potentially benefits the understanding of the FGA with the outer and planner frames. It can be expected that the frame-guided assembly strategy will enable understanding the mechanism of self-assembly and provide a clue to understand the fundamental mechanism of life.
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Dong, Y., Liu, D. (2023). The Frame-Guided Assembly of Nucleic Acids. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. https://doi.org/10.1007/978-981-19-9776-1_61
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DOI: https://doi.org/10.1007/978-981-19-9776-1_61
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