Abstract
Genomic Islands (GI) of Klebsiella pneumoniae include integrative and conjugative elements (ICEs), prophages, integrons, and transposons belonging to a group of genetic elements transferred horizontally and have integrated into the genome of K. pneumoniae. Integrative and conjugative elements of K. pneumoniae (ICEKp) are flanked by direct repeats, encode the yersiniabactin (ybt) locus, a mobilization locus-type 4 secretion system (T4SS), and other variable regions based on which they are classified into 14 types (ICEKp1–14). Their sizes range from 75–200 kb and their chromosomal insertion site is mostly one of the four tRNA-Asn sites. Each K. pneumoniae genome can harbor one to six prophages; accounting for 0.1–8% of the genome. The site of phage integration could be either the tRNA or ABC transporter permease SapC. Class I integrons are the most commonly found integrons in K. pneumoniae. They contain three essential components for the capture of external genes: an integrase, attI site, and an outwardly oriented promoter (Pc) that controls transcription of the captured genes. Conjugative transposons (CTn) in K. pneumoniae are associated with resistance (Tn916 and Tn6009) and hypervirulence (Tn6497).
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Shukla, S., Joshi, P., Trivedi, P., Akinwotu, O., Gajjar, D. (2023). Genomic Islands in Klebsiella pneumoniae. In: Mani, I., Singh, V., Alzahrani, K.J., Chu, DT. (eds) Microbial Genomic Islands in Adaptation and Pathogenicity. Springer, Singapore. https://doi.org/10.1007/978-981-19-9342-8_13
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