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Alginate Based Scaffolds in Tissue Engineering and Regenerative Medicine

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Alginate Biomaterial

Abstract

Regenerative medicine and tissue engineering appears as a new hope to biomedical world applying the principles of both science and medicine for regrowth of the injured tissue and organs of human body. Alginate is a negatively charged naturally occurring polysaccharide which has profound biomedical utilizations including drug delivery, tissue engineering, healing of different wounded tissues etc. Alginate possesses some attractive behaviors of non-toxicity, biocompatibility and gel forming ability. But owning to few difficulties, Alginate is modified easily by blending it with different other substances (both natural and synthetic materials) via different physiochemical crosslinking techniques. Oxidation of Alginate can be carried out to change its characteristics. As a result of such modifications, the alginate-based constructs are developed with improved cellular activity and mechanical strength which reflect their applications as a good scaffolding substance to mimic the corresponding ECM of the native tissue and restore its original functions. This book chapter gives almost detailed information of the structure properties of Alginate based materials and its applications in tissue engineering and regenerative medicine.

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Acknowledgements

This work is financially supported by DST-SERB funding agency through three sanctioned projects EEQ/2020/000496, EEQ/2016/000712, and ECR/2016/002018. K.S. also acknowledges UGC for UGC-BSR Research Start-Up Grant (F.30-363/2017(BSR), Dt- 08/08/2017) and CU for UPE-II Nanofabrication project fund (UGC/166/UPE-II, Dt- 03/04/2017) for financial support.

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  1. Gene Therapy and Tissue Engineering Lab, Department of Polymer Science and Technology, University of Calcutta, Kolkata, West Bengal, India

    Debleena Ghosh, Taposi Trishna Neog, Rishik Patra, Kritideepa Nath & Kishor Sarkar

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  1. Debleena Ghosh
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  2. Taposi Trishna Neog
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  3. Rishik Patra
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  4. Kritideepa Nath
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  5. Kishor Sarkar
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Correspondence to Kishor Sarkar .

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  1. Department of Health & Family Welfare, Directorate of Health Services, Kolkata, West Bengal, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Ghosh, D., Neog, T.T., Patra, R., Nath, K., Sarkar, K. (2023). Alginate Based Scaffolds in Tissue Engineering and Regenerative Medicine. In: Jana, S., Jana, S. (eds) Alginate Biomaterial. Springer, Singapore. https://doi.org/10.1007/978-981-19-6937-9_15

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