Pre-transplant Evaluation

  • Chapter
  • First Online:
Basics of Hematopoietic Stem Cell Transplant
  • 479 Accesses

Abstract

To improve the outcome of stem cell transplantation (SCT) an optimal selection of transplant recipient and an extensive pre-SCT workup should be performed. The pre-SCT workup is done to ensure sufficient organ function, rule out major infections, evaluate disease status prior to SCT, and exclude any contraindications to allogeneic SCT. The decision to recommend SCT is dependent on a number of factors including patient age, performance status, comorbidities, family support, socioeconomic condition and motivation to participate in self-care.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Feinstein AR. The pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis. 1970;23(7):455–68.

    Article  CAS  PubMed  Google Scholar 

  2. Sorror ML, Maris MB, Storb R, Baron F, Sandmaier BM, Maloney DG, et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood. 2005;106(8):2912–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sorror ML. How I assess comorbidities before hematopoietic cell transplantation. Blood. 2013;121(15):2854.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Hamadani M, Craig M, Awan FT, Devine SM. How we approach patient evaluation for hematopoietic stem cell transplantation. Bone Marrow Transplant. 2010;45(8):1259–68.

    Article  CAS  PubMed  Google Scholar 

  5. Hurley P, Konety S, Cao Q, Weisdorf D, Blaes A. Hematopoietic stem cell transplantation in patients with systolic dysfunction: can it be done? Biol Blood Marrow Transplant. 2015;21(2):300–4.

    Article  PubMed  Google Scholar 

  6. Nakamae H, Hino M, Akahori M, Terada Y, Yamane T, Ohta K, et al. Predictive value of QT dispersion for acute heart failure after autologous and allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2004;76(1):1–7.

    Article  PubMed  Google Scholar 

  7. Chien JW, Madtes DK, Clark JG. Pulmonary function testing prior to hematopoietic stem cell transplantation. Bone Marrow Transplant. 2005;35(5):429–35.

    Article  CAS  PubMed  Google Scholar 

  8. Savani BN, Montero A, Srinivasan R, Singh A, Shenoy A, Mielke S, et al. Chronic GVHD and pretransplantation abnormalities in pulmonary function are the main determinants predicting worsening pulmonary function in long-term survivors after stem cell transplantation. Biol Blood Marrow Transplant. 2006;12(12):1261–9.

    Article  PubMed  PubMed Central  Google Scholar 

  9. McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 1993;118(4):255–67.

    Article  CAS  PubMed  Google Scholar 

  10. Kersting S, Dorp SV, Theobald M, Verdonck LF. Acute renal failure after nonmyeloablative stem cell transplantation in adults. Biol Blood Marrow Transplant. 2008;14(1):125–31.

    Article  CAS  PubMed  Google Scholar 

  11. Miyata M, Ichikawa K, Matsuki E, Watanabe M, Peltier D, Toubai T. Recent advances of acute kidney injury in hematopoietic cell transplantation. Front Immunol. 2022;12:779881.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Andronesi A, Sorohan B, Burcea A, Lipan L, Stanescu C, Craciun O, et al. Incidence and risk factors for acute kidney injury after allogeneic stem cell transplantation: a prospective study. Biomedicine. 2022;10(2):262.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sharma, S.K. (2023). Pre-transplant Evaluation. In: Basics of Hematopoietic Stem Cell Transplant. Springer, Singapore. https://doi.org/10.1007/978-981-19-5802-1_54

Download citation

  • DOI: https://doi.org/10.1007/978-981-19-5802-1_54

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-5801-4

  • Online ISBN: 978-981-19-5802-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation