Abstract
Several drugs and agents in clinical practice have been found to possess mild to moderate analgesic, anti-inflammatory and antipyretic activity. This makes it essential for pharmacologists to understand the various pre-clinical models and methods available for such screening. Numerous in vitro methods have been highlighted in this chapter. In addition, focus is maintained on the in vivo models – hot plate method, tail flick technique, tail immersion method for analgesic activity assessment to mention a few, paw oedema method, granuloma pouch method, cotton wool granuloma technique for anti-inflammatory screening, and Brewer’s yeast suspension method for antipyretic activity screening.
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Bibliography
Huang BP, Lin CH, Chen YC, Kao SH. Anti-inflammatory effects of Perilla frutescens leaf extract on lipopolysaccharide stimulated RAW264.7 cells. Mol Med Rep. 2014;10:1077.
Koster R, Anderson M, de Beer EJ. Acetic acid for analgesic screening. Fed Proc. 1959;18:412.
Randal LO, Selitto JJ. A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn. 1957;111:409–19.
Sancillo LF, Nolan JC, Wagner LE, et al. The analgesic and anti-inflammatory activity and pharmacologic properties of bromfenac. Arzneim Forsch/Drug Res. 1987;37:513–9.
Shukla P, Shukla P, Mishra SB, Gopalakrishna B. Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn. Indian J Pharmacol. 2010;42(6):409–11.
Vogel HG. Analgesic, anti-inflammatory, and antipyretic activity. In: Vogel HG, editor. Drug discovery and evaluation: pharmacological assays. Germany: Springer. p. 984–1116.
Wang G, Hu Z, Song X, Cui Q, Fu Q, Jia R, et al. Analgesic and anti-inflammatory activities of resveratrol through classic models in mice and rats. Evid-based Complementary Altern Med. 2017;5197567
Winter CA, Risley EA, Silber RH. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med. 1962;111:544.
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Arivazhahan, A. (2022). Screening Methods for the Evaluation of Analgesics, Anti-Inflammatory Drugs, and Antipyretics. In: Lakshmanan, M., Shewade, D.G., Raj, G.M. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-19-5343-9_40
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DOI: https://doi.org/10.1007/978-981-19-5343-9_40
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