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Organocatalysis: A Versatile Tool for Asymmetric Green Organic Syntheses

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Green Chemistry

Abstract

An organocatalyst can be defined as small organic molecules, which can catalyze a wide range of important asymmetric organic transformations without use of transition metals and enzymes. The concept of organocatalysis emerged to develop such catalysts which could be environmentally benign, reduce the limitations associated with metal and enzyme-catalyzed reactions and of course, equally productive in terms of yield and stereoselectivity. Transition metal catalysts have wider range of applicability in chemical transformations but are toxic in nature. Enzymes, on the other hand, are environmentally benign but have limited substrate scope. Addressing these shortcomings, organocatalysts are relatively nontoxic, stable to air and water, easily handled, eco-friendly, and readily separable from crude reaction mixture which makes them a fantastic tool for organic synthesis in pharmaceutical industries and academia. Furthermore, they are inexpensive in comparison to transition metal catalysts and have wide substrate scope too. For instance, organocatalysts have broad applicability in multicomponent and multistep domino or tandem reactions, which can afford small and complex molecules like natural products with high stereoselectivity.

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Authors and Affiliations

  1. Department of Chemistry, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Vinod K. Tiwari

  2. Department of Chemistry, Mahatma Gandhi Central University, Motihari, Bihar, India

    Abhijeet Kumar

  3. Department of Chemistry, The Assam Royal Global University, Guwahati, Assam, India

    Sanchayita Rajkhowa

  4. Department of Chemistry, T. N. B. College, Bhagalpur, Bihar, India

    Garima Tripathi

  5. Department of Chemistry, Mahatma Gandhi Central University, Motihari, Bihar, India

    Anil Kumar Singh

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Tiwari, V.K., Kumar, A., Rajkhowa, S., Tripathi, G., Singh, A.K. (2022). Organocatalysis: A Versatile Tool for Asymmetric Green Organic Syntheses. In: Green Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-19-2734-8_7

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