Animal-Based Bioactive Components: Zoochemicals: A Comprehensive Review

  • Chapter
  • First Online:
Bioactive Components

Abstract

Bioactive components can be defined as components in foods that have a physiological function. In this present era, bioactive substances originating from animal origin have been identified as potential and applied for designing functional foods with numerous health benefits. Most of the evidence for bioactive effects comes from in vitro studies, and there is a need for further research to fully evaluate the true potential of milk-derived bioactive factors. Animal genetics and animal nutrition play an important role in the relative proportions of milk proteins and could be used to manipulate the concentration of specific bioactive peptides in milk from ruminants. The knowledge described in the present chapter may set the basis for further research and for the development of new functional foods with healthy and beneficial properties for humans.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Aimutis WR (2004) Bioactive properties of milk proteins with particular focus on anticariogenesis. J Nutr 134(4):989S–995S

    Article  CAS  PubMed  Google Scholar 

  • Anderson JW, Nicolosi RJ, Borzelleca JF (2005) Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food Chem Toxicol 43:187–201

    Article  CAS  PubMed  Google Scholar 

  • Asimakopoulou AP, Theocharis AD, Tzanakakis GN, Karamanos NK (2008) The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents. In Vivo 22:385–390

    CAS  PubMed  Google Scholar 

  • Beal MF (2004) Mitochondrial dysfunction and oxidative damage in Alzheimer’s and Parkinson’s diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomembr 36(4):381–386

    Article  CAS  PubMed  Google Scholar 

  • Belury MA (2002) Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Annu Rev Nutr 22:505–531

    Article  CAS  PubMed  Google Scholar 

  • Bhagavan HN, Chopra RK (2006) Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 40(5):445–453

    Article  CAS  PubMed  Google Scholar 

  • Bhatnagar A, Sillanpaa M (2009) Applications of chitin- and chitosan-derivatives for the detoxification of water and wastewater -a short review. Adv Colloid Interf Sci 152:26–38

    Article  CAS  Google Scholar 

  • Bruyere O, Reginster JY (2007) Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs Aging 24(7):573–580

    Article  CAS  PubMed  Google Scholar 

  • Bubenik GA (2002) Gastrointestinal melatonin localization, function, and clinical relevance. Dig Dis Sci 47(10):2336–2348

    Article  CAS  PubMed  Google Scholar 

  • Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ (2005) A review of the multiple actions of melatonin on the immune system. Endocrine 27(2):189–200

    Article  CAS  PubMed  Google Scholar 

  • Colegate SM, Molyneux RJ (eds) (2007) Bioactive natural products: detection, isolation, and structural determination. CRC press, Boca Raton

    Google Scholar 

  • Covington MB (2004) Omega-3 fatty acids. Am Fam Physician 70(1):133–140

    PubMed  Google Scholar 

  • Dostrovsky NR, Towheed TE, Hudson RW, Anastassiades TP (2011) The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature. Osteoarthr Cartil 19:375–380

    Article  CAS  Google Scholar 

  • FitzGerald RJ, Murray BA, Walsh DJ (2004) Hypotensive peptides from milk proteins. J Nutr 134(4):980S–988S

    Article  CAS  PubMed  Google Scholar 

  • Flanagan JL, Simmons PA, Vehige J, Willcox MD, Garrett Q (2010) Role of carnitine in disease. Nutr Metab 7:30

    Article  Google Scholar 

  • Hurot JM, Cucherat M, Haugh M, Fouque D (2002) Effects of L-carnitine supplementation in maintenance hemodialysis patients: a systematic review. J Am Soc Nephrol 13:708–714

    Article  CAS  PubMed  Google Scholar 

  • James CB, Uhl TL (2001) A review of articular cartilage pathology and the use of glucosamine sulfate. J Athl Train 36(4):413–419

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jeon YJ, Shahidi F, Kim SK (2000) Preparation of chitin and chitosan oligomers and their applications in physiological functional foods. Food Rev Int 16(2):159–176

    Article  CAS  Google Scholar 

  • Littarru GP, Tiano L (2007) Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 37(1):31–37

    Article  CAS  PubMed  Google Scholar 

  • Livney YD (2010) Milk proteins as vehicles for bioactives. Curr Opin Colloid Interface Sci 15:73–83

    Article  CAS  Google Scholar 

  • Martel-Pelletier J, Tat SK, Pelletier JP (2010) Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review. Osteoarthr Cartil 18:S7–S11

    Article  Google Scholar 

  • Meisel H (2005) Biochemical properties of peptides encrypted in bovine milk proteins. Curr Med Chem 12(16):1905–1919

    Article  CAS  PubMed  Google Scholar 

  • Meisel H, Bockelmann W (1999) Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho-functional properties. Antonie Van Leeuwenhoek 76:207–215

    Article  CAS  PubMed  Google Scholar 

  • Meyer BJ, Mann NJ, Lewis JL, Milligan GC, Sinclair AJ, Howe PRC (2003) Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids 38(4):391–398

    Article  CAS  PubMed  Google Scholar 

  • Mills E, Wu P, Seely D, Guyatt G (2005) Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res 39(4):360–366

    Article  CAS  PubMed  Google Scholar 

  • Olde Rikkert MGM, Rigaud ASP (2001) Melatonin in elderly patients with insomnia a systematic review. Z Gerontol Geriatr 34:491–497

    Article  CAS  PubMed  Google Scholar 

  • Overvad K, Diamant B, Holm L, Hulmer G, Mortensen SA, Stender S (1999) Review: coenzyme Q10 in health and disease. Eur J Clin Nutr 53:764–770

    Article  CAS  PubMed  Google Scholar 

  • Pacchierotti C, Iapichino S, Bossini L, Pieraccini F, Castrogiovanni P (2001) Melatonin in psychiatric disorders: a review on the melatonin involvement in psychiatry. Front Neuroendocrinol 22:18–32

    Article  CAS  PubMed  Google Scholar 

  • Phillips L, Appleton RE (2004) Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. Dev Med Child Neurol 46:771–775

    Article  PubMed  Google Scholar 

  • Pigman W (ed) (2012) The carbohydrates: chemistry and biochemistry. Elsevier, Amsterdam

    Google Scholar 

  • Pillai CKS, Paul W, Sharma CP (2009) Chitin and chitosan polymers: chemistry, solubility and fiber formation. Prog Polym Sci 34:641–678

    Article  CAS  Google Scholar 

  • Raes K, Smet SD, Demeyer D (2004) Effect of dietary fatty acids on incorporation of long chain polyunsaturated fatty acids and conjugated linoleic acid in lamb, beef and pork meat: a review. Anim Feed Sci Technol 113:199–221

    Article  CAS  Google Scholar 

  • Rinaudo M (2006) Chitin and chitosan: properties and applications. Prog Polym Sci 31:603–632

    Article  CAS  Google Scholar 

  • Ruxton CHS, Reed SC, Simpson MJA, Millington KJ (2004) The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence. J Hum Nutr Diet 17:449–459

    Article  CAS  PubMed  Google Scholar 

  • Salas-Salvado J, Marquez-Sandoval F, Bullo M (2006) Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev Food Sci Nutr 46:479–488

    Article  CAS  PubMed  Google Scholar 

  • Sanchez-Barcelo EJ, Fernandez R, Cos S, Mediavilla MD (2003) Melatonin and mammary cancer: a short review. Endocr Relat Cancer 10:153–159

    Article  CAS  PubMed  Google Scholar 

  • Sanders LM, Zeisel SH (2007) Choline: dietary requirements and role in brain development. Nutr Today 42(4):181–186

    Article  PubMed  PubMed Central  Google Scholar 

  • Sarter B (2002) Coenzyme Q10 and cardiovascular disease: a review. J Cardiovasc Nurs 16(4):9–20

    Article  PubMed  Google Scholar 

  • Schmid A, Collomb M, Sieber R, Bee G (2006) Conjugated linoleic acid in meat and meat products: a review. Meat Sci 73:29–41

    Article  CAS  PubMed  Google Scholar 

  • Shahidi F, Wanasundara UN (1998) Omega-3 fatty acid concentrates: nutritional aspects and production technologies. Trends Food Sci Technol 9(6):230–240

    Article  CAS  Google Scholar 

  • Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Lew M (2002) Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 59(10):1541–1550

    Article  PubMed  Google Scholar 

  • Simonneaux V, Ribelayga C (2003) Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55:325–395

    Article  CAS  PubMed  Google Scholar 

  • Simopoulos AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54:438–463

    Article  CAS  PubMed  Google Scholar 

  • Singh U, Devaraj S, Jialal I (2007) Coenzyme Q10 supplementation and heart failure. Nutr Rev 65(6):286–293

    Article  PubMed  Google Scholar 

  • Steiber A, Kerner J, Hoppel CL (2004) Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Asp Med 25:455–473

    Article  CAS  Google Scholar 

  • Uebelhart D (2008) Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthr Cartil 16:S19–S21

    Article  Google Scholar 

  • Vangsness CT Jr, Spiker W, Erickson J (2009) A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthrosc J Arthrosc Relat Surg 25(1):86–94

    Article  Google Scholar 

  • Zeisel SH (1981) Dietary choline: biochemistry, physiology, and pharmacology. Annu Rev Nutr 1:95–121

    Article  CAS  PubMed  Google Scholar 

  • Zeisel SH, Blusztajn JK (1994) Choline and human nutrition. Annu Rev Nutr 14:269–296

    Article  CAS  PubMed  Google Scholar 

  • Zhou X, Liu F, Zhai S (2007) Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. Asia Pac J Clin Nutr 16(Suppl 1):383–390

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sindhav, R.G., Hazra, T., Mudgil, D. (2023). Animal-Based Bioactive Components: Zoochemicals: A Comprehensive Review. In: Thakur, M., Belwal, T. (eds) Bioactive Components . Springer, Singapore. https://doi.org/10.1007/978-981-19-2366-1_3

Download citation

Publish with us

Policies and ethics

Navigation