Abstract
Next-generation sequencing approach has been used to describe the virome of the eye with ocular diseases only with respect to one disease in which the vitreous fluid virome of post-fever retinitis (PFR) patients was compared with the virome generated from the vitreous of individuals free of any ocular infection. Several viral families (68 families) and genera (213 genera) were identified in the vitreous fluid of both the cohorts. The abundance of families Astroviridae, Polyomaviridae and Birnaviridae was significantly different in the two cohorts of PFR and control group. Several eukaryotic viral genera (30) and bacteriophages (24) could be used to discriminate the viromes of the PFR individuals with control individuals without any ocular disease. That the viromes were different between the controls and the PFR cohorts was also confirmed by heatmap analysis, non-metric multidimensional scaling analysis, principal coordinate analysis and linear discriminating analysis. Functional analysis of the viruses based on known functions of the genera hints at a possible role for pathogenic viruses in PFR.
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Shivaji, S. (2022). Virome of the Diseased Human Eye. In: Human Ocular Microbiome. Springer, Singapore. https://doi.org/10.1007/978-981-19-1754-7_9
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