Abstract
Malnutrition is a current global challenge faced by mankind, mainly caused due to deficiency and excess of macro and micronutrients such as growth retardation, anemia, mental retardation, overweight, night blindness, reduced IQ, neural tube defects, cancer, hypertension and depression, etc. According to UNICEF, India was at the tenth position among countries with the highest number of underweight children and at the 17th position for the highest number of stunted children in the world. Fortification of staple food with macro and micronutrients is the common practice to meet the deficiency disorders and to provide complete growth. Despite decades of scientific research in this area, still complications arise for establishing connecting links from individual energy intake levels of targeted population to policy making, implementation, and evolution. Thus, the present chapter aims to cover the details about field testing kits for analysis fortificant levels of iron and vitamin followed by brief concepts about the practicing methods used for diet assessment at individual, household, and population level to decision making at analyst and policy maker levels during implementation of food fortification program. Overview of field-testing tools and fortification program analysis methods could help for development of more stringent protocol which could meet the global standards for implementation of fortification program.
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References
AACC International (2002) Approved methods of analysis, method 40-70. Elements by atomic absorption spectrophotometry. St. Paul, AACC International
Araújo MM, Marchioni E, Villavicencio ALCH, Zhao M, Zimmermann P, El-Khoury E, Bergaentzle M (2012a) Pressurized liquid extraction and HPLC quantification of folic acid in fortified wheat flours. J Agric Food Chem 60(31):7629–7623
Araújo MM et al (2012b) Pressurized liquid extraction and HPLC quantification of folic acid in fortified wheat flours. J Agric Food Chem 60(31):7629–7633. https://doi.org/10.1021/jf3025503
Berti PR (2012) Intrahousehold distribution of food: a review of the literature and discussion of the implications for food fortification programs. Food Nutr Bull 33:S163–S169
Blake CJ (2007) Analytical procedures for water-soluble vitamins in foods and dietary supplements: a review. Anal Bioanal Chem 389:63–76. https://doi.org/10.1007/s00216-007-1309-9
Bogachuk MN, Bessonov VV, Perederiaev O (2011) Methods quantitative for determination of water-soluble vitamins in premixes and fortified food products by micellar electrokinetic chromatography on short end of the capillary. Vopr Pitan 80(3):67–74. Russian
Byrdwell WC (2009) Comparison of analysis of vitamin D3 in foods using ultraviolet and mass spectrometric detection. J Agric Food Chem 57:2135–2146
Byrdwell WC, Devries J, Exler J, Harnly JM, Holden JM, Holick MF, Wolf WR (2008) Analyzing vitamin D in foods and supplements: methodologic challenges. Am J Clin Nutr 88(2):554S–557S
Byrdwell WC, Exler J, Gebhardt SE, Harnley JM, Holden JM, Horst RL, Wolf WR (2011) Liquid chromatography with ultraviolet and dual parallel mass spectrometric detection for analysis of vitamin D in retail fortified orange juice. J Food Compos Anal 24:299–306
Coates J, Colaiezzi B, Fiedler JL, Wirth J, Lividini K, Rogers B (2012) A program needs-driven approach to selecting dietary assessment methods for decision-making in food fortification programs. Food Nutr Bull 33:S146–S156
Dary O (2011) A new test kit’s potential for the rapid analysis of Vitamin A in human and cow milk. Sight Life Magaz 25:201
Dary O, Imhoff-Kunsch B (2012) Measurement of food consumption to inform food fortification and other nutrition programs: an introduction to methods and their application. Food Nutr Bull 33:S141–S145
De Oliveira E, Silva AF, De Castro WV, De Andrade FP (2018) Development of spectrophotometric method for iron determination in fortified wheat and maize flours. Food Chem 242:205–210
De Vries J, Silvera K (2002) Determination of vitamins (retinol) and E (alpha-tocopherol) in foods by liquid chromatography: collaborative study. J AOAC Int 85(2):424–434
Dearth-Wesley T, Makhmudov A, Pfeiffer CM, Caldwell K (2004) Fast and reliable salt iodine measurement: evaluation of the WYD iodine checker in comparison with iodometric titration. Food Nutr Bull 25:130–136
Engle-Stone R (2014) Comparison of breast milk vitamin A concentration measured in fresh milk by a rapid field assay (the iCheck FLUORO) with standard measurement of stored milk by HPLC. Eur J Clin Nutr 68(8):938–940
Fernandez-Rao S, Hurley KM, Nair KM, Balakrishna N, Radhakrishna KV, Ravinder P, Tilton N, Harding KB, Reinhart GA, Black MM (2014) Integrating nutrition and early child-development interventions among infants and preschoolers in rural India. Ann N Y Acad Sci 1308:218–231
Filik H, Giray D (2012) Cloud point extraction for speciation of iron in beer samples by spectrophotometry. Food Chem 130:209–213
Fontannaz P, Kilinc T, Heudi O (2006) HPLC–UV determination of total vitamin C in a wide range of fortified food products. Food Chem 94:626–631
Friesen VM, Aaron GJ, Myatt M, Neufeld LM (2017) Assessing coverage of population-based and targeted fortification programs with the use of the fortification assessment coverage toolkit (FACT): background, toolkit development, and supplement overview. J Nutr 147:981S–983S
Gan SD, Patel KR (2013) Enzyme immunoassay and enzyme-linked immunosorbent assay. J Invest Dermatol 133:1–3. https://doi.org/10.1038/jid.2013.287
Garrido Frenich A, Hern Andez Torres ME, Belmonte Vega A, Martà Nez Vidal JL, Plaza Bola P (2005) Determination of ascorbic acid and carotenoids in food commodities by liquid chromatography with mass spectrometry detection. J Agric Food Chem 53:7371–7376
Gill BD, Abernethy GA, Green RJ, Indyk HE (2016) Analysis of vitamin D2 and vitamin D3 in fortified milk powders and infant and nutritional formulas by liquid chromatography-tandem mass spectrometry: single- laboratory validation. J AOAC Int 99(5):1321–1330. https://doi.org/10.5740/jaoacint.16-0160
Guamuch M, Makhumula P, Dary O (2007a) Manual of laboratory methods for fortified foods (vitamin a, riboflavin, iron and iodine)—part I. Arusha, Tanzania
Guamuch M, Makhumula P, Dary O (2007b) Procedures for determining iron flour. In: Manual of laboratory methods for fortified foods, 1st edn. East, Central and Southern Health Community, Arusha, pp 7–16
Guan DD, Guo LL, Liu LQ, Kong N, Kuang H, Xu CL (2015) Development of an ELISA for nitrazepam based on a monoclonal antibody. Food Agric Immunol 26:611–621. https://doi.org/10.1080/09540105.2014.998637
Hanson NC (2020) Novel methods for identification and quantification of iron fortificants in cereal flours. Graduate theses and dissertations 17973
Hess SY, Brown KH, Sablah M, Engle-Stone R, Aaron GJ, Baker SK (2013) Results of fortification rapid assessment tool (FRAT) surveys in sub-Saharan Africa and suggestions for future modifications of the survey instrument. Food Nutr Bull 34:21–38
Horwitz W, Latimer GW (2007) AOAC official method 2001.13.Vitamin a (retinol) in foods. In: Vitamins and other nutrients. Official methods of Analysis of AOAC International, Maryland, pp 53–56
Hurrell RF (2002) Fortification: overcoming technical and practical barriers. J Nutr 132:806S–812S
Jakobsen J, Saxholt E (2009) Vitamin D metabolites in bovine milk and butter. J Food Compos Anal 22(5):472–478
Jaramillo AM, Londoño LF, Orozco JC, Patiño G, Belalcazar J, Davrieux F et al (2018) A comparison study of five different methods to measure carotenoids in biofortified yellow cassava (Manihot esculenta). PLoS One 13(12):e0209702. https://doi.org/10.1371/journal.pone.0209702
Johnson QW, Wesley AS (2010) Miller’s best/enhanced practices for flour fortification at the flour mill. Food Nutr Bull 31(1 suppl):S75–S85
Kazmi SA, Vieth R, Rousseau D (2007) Vitamin D3 fortification and quantification in processed dairy products. Int Dairy J 17(7):753–759
Kloosterman JV, Seves SM, Ocké MC (2017) Vitamin D concentrations in fortified foods and dietary supplements intended for infants: implications for vitamin D intake. Food Chem 221:629–635. https://doi.org/10.1016/j.foodchem.2016.11.128
Kong D, Liu L, Song S et al (2017) Development of sensitive, rapid, and effective immunoassays for the detection of vitamin B12 in fortified food and nutritional supplements. Food Anal Methods 10:10–18. https://doi.org/10.1007/s12161-016-0543-1
Krawinkel MB et al (2009) Evaluation of the test kit for vitamin a in fortified vegetable oils developed by BASF. Institute of Nutritional Science, Justus Liebig University, Gießen
Kulkarni PS, Dhar SD, Kulkarni SD (2013) A rapid assessment method for determination of iodate in table salt samples. J Anal Sci Technol 4:21
Laillou A (2013) Assessment of a portable device to quantify vitamin A in fortified foods (flour, sugar, and milk) for quality control. Food Nutr Bull 35:449
Lanina S, Toledo P, Samples S, Kamal-Eldin A, Jastrebova J (2007) Comparison of reversed - phase liquid chromatography – mass spectrometry with electrospray and atmospheric pressure chemical ionization techniques for determination of tocopherols in foods. J Chromatogr A 1157:159–170
Lebiedzińska M, Dbrowska PS, Marszałł M (2008) High-performance liquid chromatography method for the determination of folic acid in fortified food products. Toxicol Mech Methods 18(6):463–467. https://doi.org/10.1080/15376510701623870
Nair S, Singh MB, Sharma SK, Pandey RM, Kapil U (2012) A multicentric study on validation of spot testing kit. Indian J Pediatr 79(751-4):17
Naz N, Kashif A, Sheikh W, Abbas M, Khan AM (2016) Analysis of water soluble vitamins (thiamine, nicotinamide and pyridoxine) in fortified infant food products by Hplc. Orient J Chem 32:2
Neufeld LM, Baker S, Garrett GS, Haddad L (2017) Coverage and utilization in food fortification programs: critical and neglected areas of evaluation. J Nutr 147:1015S–1019S
Nichols E, Aburto N, Masad H, Wirth J, Sullivan K, Serdula M (2012) Performance of iron spot test with Arabic bread made from fortified white wheat flour. Food Nutr Bull 33:202–206
Niedzielski P, Zielinska-Dawidziak M, Kozak L, Kowalewski P, Szlachetka B, Zalicka S, Wachowiak W (2014) Determination of iron species in samples of iron-fortified food. Food Anal Methods 7:2023–2032
Osendarp SJ, Martinez H, Garrett GS, Neufeld LM, De-Regil LM, Vossenaar M, Darnton-Hill I (2018) Large-scale food fortification and biofortification in low-and middle-income countries: a review of programs, trends, challenges, and evidence gaps. Food Nutr Bull 39:315–331
Pachon H, Spohrer R, Mei Z, Serdula MK (2015) Evidence of the effectiveness of flour fortification programs on iron status and anemia: a systematic review. Nutr Rev 73:780–795
Pandav CS, Arora NK, Krishnan A, Sankar R, Pandav S, Karmarkar MG (2000) Validation of spot-testing kits to determine iodine content in salt. Bull World Health Organ 78:975–980
Perring L, Andrey D, Basic-Dvorzak M, Hammer D (2005) Rapid quantification of iron, copper and zinc in food premixes using energy dispersive X-ray fluorescence. J Food Compos Anal 18(7):655–663
Petry N, Nizamov F, Woodruff BA, Ishmakova R, Komilov J, Wegmüller R, Wirth JP, Arifdjanova D, Guo S, Rohner F (2020) Risk factors for anemia and micronutrient deficiencies among women of reproductive age—the impact of the wheat flour fortification program in Uzbekistan. Nutrients 12:714
Phillips KMC, Byrdwell WE, Xler J, Harnly JM, Holden JM, Holick MF, Hollis BW, Horst RL, Lemar LE, Patterson KY, Tarrago-Trani MT, Wolf WR (2008) Development and validation of control materials for the measurement of vitamin D3 in selected US foods. J Food Compos Anal 21(7):527–534
Poitevin E (2012) Determination of calcium, copper, iron, magnesium, manganese, potassium, phosphorus, sodium, and zinc in fortified food products by microwave digestion and inductively coupled plasma-optical emission spectrometry: single-laboratory validation and ring trial. J AOAC Int 95(1):177–185. https://doi.org/10.5740/jaoacint.cs2011_14
Renaud C (2013) Quantification of vitamin A in fortified rapeseed, groundnut and soya oils using a simple portable device: comparison to high performance liquid chromatography. Int J Vitam Nutr Res 83:122
Rohner F (2011) Quantification of vitamin A in palm oil using a fast and simple portable device: method validation and comparison to high-performance liquid chromatography. Int J Vitam Nutr Res 81:335
Rohner F, Garrett GS, Laillou A, Frey SK, Mothes R, Schweigert FJ et al (2012) Validation of a user-friendly and rapid method for quantifying iodine content of salt. Food Nutr Bull 33(Suppl):S330–S335
Rohner F, Garrett GS, Laillou A, Frey SK, Mothes R, Schweigert FJ et al (2015) Comparative validation of five quantitative rapid test kits for the analysis of salt iodine content: laboratory performance, user- and field-friendliness. PLoS One 10(9):e0138530. https://doi.org/10.1371/journal.pone.0138530
Sanchez-Mena JD, Zambo Z, Orozco M, Solomons NW (2012) Vitamin a content in sugar determined by a rapid assay device (Icheck® FLUORO). Center for studies of sensory impairment, aging and metabolism. Bull Res 23:1–5
Schweigert F, Frey S, Mothes R, Dary O, Juarez P, Lascano V (2011) A new test kit’s potential for the rapid analysis of vitamin a in human and cow milk. Sight Life 3:18–22
Silva AFO, Castro WV, Andrade FP (2018) Development of spectrophotometric method for iron determination in fortified wheat and maize flours. Food Chem 242:205–210. https://doi.org/10.1016/j.foodchem.2017.08.110
Soeiro BT, Boen TR, Pereira-Filho ER, Lima-Pallone JA (2010) Investigação da qualidade de farinhas enriquecidas utilizando análise por componentes principais (PCA). Ciência e Tecnologia de Alimentos 30(3):618–624
Spohrer R, Larson M, Maurin C, Laillou A, Capanzana M, Garrett GS (2013) The growing importance of staple foods and condiments used as ingredients in the food industry and implications for large-scale food fortification programs in Southeast Asia. Food Nutr Bull 34:S50–S61
Srivastava A, Mahmood SE, Srivastava PM, Shrotriya VP, Kumar B (2012) Nutritional status of school-age children-a scenario of urban slums in India. Archiv Public Health 70:1–8
Waller AW, Toc M, Rigsby DJ, Gaytán-MartÃnez M, Andrade JE (2019) Development of a paper-based sensor compatible with a mobile phone for the detection of common iron formulas used in fortified foods within resource-limited settings. Nutrients 11:1673
Wegmüller R, Zimmermann M, Hurrell R (2003) Dual fortification of salt with iodine and encapsulated iron compounds: stability and acceptability testing in Morocco and Côte d'Ivoire. J Food Sci 68:2129–2135. https://doi.org/10.1111/j.1365-2621.2003.tb07031.x
Wimalawansa SJ (2013) Rational food fortification programs to alleviate micronutrient deficiencies. J Food Process Technol 4:257–267
Yadav K, Kumar R, Chakrabarty A, Pandav CS (2015) A reliable and accurate portable device for rapid quantitative estimation of iodine content in different types of edible salt. Indian J Public Health 59:204–209
Yuan JS, Li Y, Ue O, Wesley JW, Diosady AS, L. L. (2008) Development of field test kits for determination of microencapsulated iron in double-fortified salt. Food Nutr Bull 29(4):288–296. https://doi.org/10.1177/156482650802900405
Zambo Z (2013) Mounting and adaptation of a fluorescent rapid-assay device (iCheckâ„¢ FLUORO) for Vitamin A in sugar and Biological Fluids. Sight Life Magaz 27:5
Zambo Z, Sanchez-Mena JD, Orozco M, Solomons NW (2012) Mounting and adaptation of a fluorescent rapid-assay device (Icheck® FLUORO) for vitamin a in sugar and biological fluids. Bull Res Abstr 23:1–4
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Patruni, K., Kaur, G. (2022). Recent Aspects of Fortified Foods: An Overview on Field Testing Tools and Fortification Program Analysis Methods. In: Kumar, A., Patruni, K., Singh, V. (eds) Recent Advances in Food Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-16-8125-7_12
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