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Hydrogel Scaffolds Based on Alginate, Gelatin, and 2-Hydroxyethyl Methacrylate for Tissue Regeneration

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Abstract

The design of bioactive scaffolding materials with favorable properties is paramount for successful application in biomedical engineering. Polymeric hydrogels attract significant attention as leading candidates for scaffold engineering due to their specific compositional and structural similarities to the natural extracellular matrix. The ability to control porosity, surface morphology, and size of hydrogel scaffolds has created new approaches to overcome various issues in tissue engineering such as vascularization, tissue architecture, and simultaneous multiple cells seeding. This review imparts an overview of hydrogel scaffolds based on synthetic and natural polymeric components (alginate, gelatin, and 2-hydroxyethyl methacrylate). We made hydrogel scaffolds with unique properties. Their in vitro and in vivo biological response, morphology, mechanical properties, porosity, hydrophilicity, and degradability were tested to find optimal patterns of tissue regeneration.

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Acknowledgments

This research is supported by the SCOPES program of the Swiss National Science Foundation and the Swiss Agency for Development and Cooperation [Grant No IZ73ZO_152327]. This work is supported by the Ministry for Education, Science, and Technological Development of the Republic of Serbia (Contracts Nos. 451-03-9/2021-14/172062 and 451-03-9/2021-14/172026).

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Authors and Affiliations

  1. Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

    Simonida Lj. Tomić, Marija M. Babić & Jovana S. Vuković

  2. Advanced Materials Department, Jožef Stefan Institute, Ljubljana, Slovenia

    Marija Vukomanović

  3. Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia

    Jasmina Nikodinović-Runić

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  1. Simonida Lj. Tomić
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Correspondence to Simonida Lj. Tomić .

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  1. Department of Health & Family Welfare, Directorate of Health Services, Kolkata, West Bengal, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Tomić, S.L., Vukomanović, M., Nikodinović-Runić, J., Babić, M.M., Vuković, J.S. (2022). Hydrogel Scaffolds Based on Alginate, Gelatin, and 2-Hydroxyethyl Methacrylate for Tissue Regeneration. In: Jana, S., Jana, S. (eds) Marine Biomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-5374-2_6

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