Abstract
Bioimaging devices use the optical properties of hemoglobin (Hb) have become widespread in medical care. The aim of the present study was to develop a device that noninvasively and quantitatively images the Hb amount and oxygen saturation of tissues remotely and in real time, in addition to providing color imaging and to examine its applicability. While detecting the RGB color, the reflected light of two narrow bands (671 ± 10 and 830 ± 10 nm) was detected simultaneously and used as a correlated value of Hb oxygen saturation. The sum of the reflected luminance at 671 and 830 nm was set as the value correlated with the tissue Hb amount. Therefore, by quantitatively imaging the tissue Hb oxygen saturation and Hb amount associated with the status of tissue oxygen metabolism, it is possible to noninvasively determine in real time not only the status of the blood flow but also the presence and condition of tumors and the degree and the process of inflammation, which can be used for the surgical navigation.
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References
Zheng P, Xu P, Yao Q, Tang K, Lou Y. 3D-printed navigation template in proximal femoral osteotomy for older children with developmental dysplasia of the hip. Sci Rep. 2017;7:44993.
Jermakowicz WJ, Diaz RJ, Cass SH, Ivan ME, Komotar RJ. Use of a mobile intraoperative computed tomography scanner for navigation registration during laser interstitial thermal therapy of brain tumors. World Neurosurg. 2016;94:418–25.
Nishino H, Hatano E, Seo S, Nitta T, Saito T, Nakamura M, Hattori K, Takatani M, Fuji H, Taura K, Uemoto S. Real-time navigation for liver surgery using projection map** with indocyanine green fluorescence: development of the novel medical imaging projection system. Ann Surg. 2018;267(6):1134–40.
Westhorpe RN, et al. The pulse oximeter. Anaesth Intensive Care. 2008;36:767.
Movahedian AH, Mosayebi Z, Sagheb S. Evaluation of pulse oximetry in the early detection of cyanotic congenital heart disease in newborns. J Tehran Heart Cent. 2016;11(2):73–8.
Welsh EJ, Carr R. Pulse oximeters to self monitor oxygen saturation levels as part of a personalized asthma action plan for people with asthma. Cochrane Database Syst Rev. 2015;27(9):CD011584.
Colas-Ribas C, Signolet I, Henni S, Feuillloy M, Gagnadoux F, Abraham P. High prevalence of known and unknown pulmonary diseases in patients with claudication during exercise oximetry: a retrospective analysis. Medicine. 2016;95(40):e4888.
Severinghaus JW, Astrup PB. History of blood gas analysis. I. The development of electrochemistry. J Clin Monit Comput. 1985;1(3):180–92.
Watanabe E, Yamashita Y, Maki A, Ito Y, Koizumi H. Non-invasive functional map** with multi-channel near infra-red spectroscopic topography in humans. Neurosci Lett. 1996;205(1):41–4.
Chang H, Kim YL, Hassan A, Fitzgerald PJ. Whole blood reflectance for assessment of hematologic condition and detection of angiographic contrast media. Appl Opt. 2009;48(13):2435–43.
Peters RA. Chemical nature of specific oxygen capacity in haemoglobin. J Physiol. 1912;44(3):131–49.
Tsutusmi R, Ikeda T, Nagahara H, Saeki H, Nakashima Y, Oki E, Maehara Y, Hashizume M. Efficacy of novel multispectral imaging device to determine anastomosis for esophagogastrostomy. J Surg Res. 2019;242:11–22.
Rubinstein DL, Ravikovich HM. Absorption spectrum of haemoglobin in red cells. Nature. 1946;158(4026):952.
Horecker BL. The absorption spectra of hemoglobin and its derivatives in the visible and near infra-red regions. J Biol Chem. 1943;148(1):173–83.
Yasuda T, Saito T, Kihara T, Takatani S, Funakubo A. Development of a reflected optical fiber system for measuring oxygen saturation in an integrated artificial heart-lung system. Artif Organs. 2008;32(3):229–34.
Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, Weichselbaum RR. Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 1999;59(14):3374–8.
Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P, Hlatky L, Debus J, Howlett AR, Huber PE. SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res. 2003;63(13):3755–63.
Mallidi S, Luke GP, Emelianov S. Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance. Trends Biotechnol. 2011;29(5):213–21.
Welter M, Fredrich T, Rinneberg H, Reiger H. Computational model for tumor oxygenation applied to clinical data on breast tumor hemoglobin concentrations suggests vascular dilatation and compression. PLoS One. 2016;11(8):e0161267.
Hong BJ, Kim J, Jeong H, Bok S, Kim YE, Ahn GO. Tumor hypoxia and reoxygenation: the yin and yang for radiotherapy. Radiat Oncol J. 2016;34(4):239–49.
Wagner F, Hakami YA, Warncock G, Fischer G, Hueller MW, Veit-Haibach P. Comparison of contrast-enhanced CT and [18F]FDG PET/CT analysis using kurtosis and skewness in patients with primary colorectal cancer. Mol Imaging Biol. 2017;19(5):795–803.
Bhunchet E, Shibata T. Proposal for two strategies to prevent remnants of gastric cancers after endoscopic mucosal resections: fluorescein electronic endoscopy and rapid stump diagnosis based on pit patterns. Gastric Cancer. 2004;7(4):221–32.
Mohammed N, Subramanian V. Clinical relevance of endoscopic assessment of inflammation in ulcerative colitis: can endoscopic evaluation predict outcomes? World J Gastroenterol. 2016;22(42):9324–32.
Hasmann A, Wehrschuetz-Sigl E, Kanzler G, Gewessler U, Hulla E, Schneider KP, Binder B, Schintler M, Guebitz GM. Novel peptidoglycan-based diagnostic devices for detection of wound infection. Diagn Microbiol Infect Dis. 2011;71(1):12–23.
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Haruta, Y., Tsutsumi, R., Naotaka, K., Nagahara, H., Ikeda, T. (2021). Novel Multispectral Device for Quantitative Imaging of Tissue Oxygen Saturation and Hemoglobin as Surgical Navigation Device. In: Takenoshita, S., Yasuhara, H. (eds) Surgery and Operating Room Innovation. Springer, Singapore. https://doi.org/10.1007/978-981-15-8979-9_10
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DOI: https://doi.org/10.1007/978-981-15-8979-9_10
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