Abstract
Biosurfactants produced by different types of microorganisms are amphiphilic biomolecules with active surface properties. Recently, biosurfactants have emerged as promising agents for cancer therapy since a high diversity of these molecules has shown the ability to induce cytotoxicity against many cancer cell lines, thus regulating cancer progression processes. In this sense, microbial biosurfactants are a potential alternative to current cancer therapeutics and as drug delivery systems of anti-cancer drugs. This chapter covers the current knowledge of microbial surfactants with anti-cancer potential, providing information on their production, structure, and research on diverse cancer cell lines, namely, breast and lungs cancer, leukemia, melanoma, and colon cancer. The potential application of biosurfactants in drug delivery is also reviewed.
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Acknowledgments
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES. This work was financially supported by POCI-01-0145-FEDER-031268—funded by FEDER, through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (OE), through FCT/MCTES. Ana P. M. Tavares acknowledges the FCT Investigator Programme and Exploratory Project (IF/01634/2015) with financing from the European Social Fund and the Human Potential Operational Programme. João C. F. Nunes acknowledges SPQ and FCT for the PhD fellowship (SFRH/BD/150671/2020). Flávia Magalhães acknowledges the SPQ and FCT PhD grant (SFRH/BD/150669/2020).
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Magalhães, F.F. et al. (2021). Anti-Cancer Biosurfactants. In: Inamuddin, Ahamed, M.I., Prasad, R. (eds) Microbial Biosurfactants. Environmental and Microbial Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-15-6607-3_8
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