Abstract
Borage (Borago officinalis L.) seed is the richest source of γ-linolenic acid (GLA), which has been recognised to possess therapeutic potential against chronic inflammatory diseases such as atopic dermatitis (eczema), rheumatoid arthritis, cancer, atherosclerosis, etc. Under physiological conditions, the conversion of GLA into dihomo-γ-linolenic acid (DGLA) not only acts as the precursor of anti-inflammatory compounds but also inhibits the formation of pro-inflammatory eicosanoids from arachidonic acid (AA). Several animal and clinical trials have suggested the protective role of borage oil and GLA in the treatment of non-communicable diseases (NCDs) possibly due to their antioxidative and anti-inflammatory activities. The other parts of borage herb such as leaves and flowers are edible and consumed as raw and cooked in the form of salad and beverages. However, owing to the medicinal value of GLA, borage is commercially grown for its oil worldwide. In addition to GLA, borage oil contains minor quantity of tocopherols, phytosterols and squalene and, thus, used frequently in cosmetic products also.
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17 March 2021
Correction to: Chapter 14 in: B. Tanwar, A. Goyal (eds.), Oilseeds: Health Attributes and Food Applications, https://doi.org/10.1007/978-981-15-4194-0_14
References
Abd El All HS, Shoukry NS, El Maged RA, Ayada MM (2007) Immunohistochemical expression of interleukin 8 in skin biopsies from patients with inflammatory acne vulgaris. Diagn Pathol 2:1–6. https://doi.org/10.1186/1746-1596-2-4
Bamford JT, Ray S, Musekiwa A, Van Gool C, Humphreys R, Ernst E (2013) Oral evening primrose oil and borage oil for eczema. Cochrane Database Syst Rev 4:1–91. https://doi.org/10.1002/14651858.CD004416.pub2
Beaubaire N, Simon JE (1987) Production of Borago officinalis L. Acta Hortic 208:101–114. https://doi.org/10.17660/ActaHortic.1987.208.12
Belch JJ, Hill A (2000) Evening primrose oil and borage oil in rheumatologic conditions. Am J Clin Nutr 71(1):352s–356s. https://doi.org/10.1093/ajcn/71.1.352s
Belkind-Gerson J, Carreón-Rodríguez A, Contreras-Ochoa CO, Estrada-Mondaca S, Parra-Cabrera MS (2008) Fatty acids and neurodevelopment. J Pediatr Gastroenterol Nutr 1(47):S7–S9
Bhatt P, Negi PS (2012) Antioxidant and antibacterial activities in the leaf extracts of Indian borage (Plectranthus amboinicus). Food Nutr Sci 3:146–152. https://doi.org/10.4236/fns.2012.32022
Bos AF (2013) Bayley-II or Bayley-III: what do the scores tell us? Dev Med Child Neurol 55(11):978–979
Brosche T, Platt D (2000) Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people. Arch Gerontol Geriatr 30:139–150
Camargo CQ, Brunetta HS, Nunes EA (2018) Effects of cotreatment with omega-3 polyunsaturated fatty acids and anticancer agents on oxidative stress parameters: a systematic review of in vitro, animal, and human studies. Nutr Rev 76(10):765–777
Chapkin RS, Coble KJ (1991) Utilization of gamma-linolenic acid by mouse peritoneal macrophages. Biochim Biophys Acta 1085:365–370
Chas M, Goupille C, Arbion F, Bougnoux P, Pinault M, Jourdan ML, Chevalier S, Ouldamer L (2019) Low eicosapentaenoic acid and gamma-linolenic acid levels in breast adipose tissue are associated with inflammatory breast cancer. Breast 45:113–117
Chung S, Kong S, Seong K, Cho Y (2002) Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. J Nutr 132:3090–3097
Czaplicki S, Ogrodowska D, Derewiaka D, Tańska M, Zadernowski R (2011) Bioactive compounds in unsaponifiable fraction of oils from unconventional sources. Eur J Lipid Sci Technol 113(12):1456–1464
Dawczynski C, Hackermeier U, Viehweger M, Stange R, Springer M, Jahreis G (2011) Incorporation of n-3 PUFA and γ-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis-a randomized controlled human intervention trial. Lipids Health Dis 10(1):1–12. https://doi.org/10.1186/1476-511X-10-130
De Smet PAGM (1993) Borago officinalis. In: Adverse effects of herbal drugs 2. Springer, Berlin, Heidelberg, pp 147–152
Dodson CD, Stermitz FR (1986) Pyrrolizidine alkaloids from borage (Borago officinalis) seeds and flowers. J Nat Prod 49(4):727–728
Dubois V, Breton S, Linder M, Fanni J, Parmentier M (2007) Fatty acid profiles of 80 vegetable oils with regard to their nutritional potential. Eur J Lipid Sci Technol 109(7):710–732
Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y (2017) Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci 13(4):851–863
Fabrikov D, Guil-Guerrero JL, González-Fernández MJ, Rodríguez-García I, Gómez-Mercado F, Urrestarazu M, Lao MT, Rincón-Cervera MÁ, Álvaro JE, Lyashenko S (2019) Borage oil: tocopherols, sterols and squalene in farmed and endemic-wild Borago species. J Food Compos Anal 83:103299. https://doi.org/10.1016/j.jfca.2019.103299
Fan YY, Chapkin RS (1998) Importance of dietary γ-linolenic acid in human health and nutrition. J Nutr 128(9):1411–1414
FDA (2016). https://www.fda.gov/media/99226/download. Accessed 15 October 2019
Fewtrell MS, Abbott RA, Kennedy K, Singhal A, Morley R, Caine E, Jamieson C, Cockburn F, Lucas A (2004) Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. J Pediatr 144(4):471–479
Foster RH, Hardy G, Alany RG (2010) Borage oil in the treatment of atopic dermatitis. Nutrition 26(7–8):708–718
Fujii M, Nakashima H, Tomozawa J, Shimazaki Y, Ohyanagi C, Kawaguchi N, Ohya S, Kohno S, Nabe T (2013) Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice. Exp Dermatol 22(4):272–277
Godos J, Sinatra D, Blanco I, Mulè S, La Verde M, Marranzano M (2017) Association between dietary phenolic acids and hypertension in a Mediterranean cohort. Nutrients 9(10):1–13. https://doi.org/10.3390/nu9101069
Gomez AM, De la Ossa EM (2002) Quality of borage seed oil extracted by liquid and supercritical carbon dioxide. Chem Eng J 88(1–3):103–109
Grand View Research (2016). Borage oil market size, share & trend analysis report by application (cosmetics, medical, dietary supplements) by region and segment forecast, 2016–2022. https://www.grandviewresearch.com/industry-analysis/borage-oil-market. Accessed 10 October 2019
Gupta SK, Negi SP (2016) Antibacterial activity of Indian borage (Plectranthus amboinicus Benth) leaf extracts in food systems and against natural microflora in chicken meat. Food Technol Biotechnol 54(1):90–96
Henz BM, Jablonska S, Stingl G, Blaszczyk M, Vandervalk PG, Veenhuizen R, Muggli R, Raederstorff D (1999) Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol 140(4):685–688
Herrmann M, Joppe H, Schmaus G (2002) Thesinine-4′-O-β-D-glucoside the first glycosylated plant pyrrolizidine alkaloid from Borago officinalis. Phytochemistry 60(4):399–402
Horvei LD, Grimnes G, Hindberg K, Mathiesen EB, Njølstad I, Wilsgaard T, Brox J, Braekkan SK, Hansen JB (2016) C-reactive protein, obesity, and the risk of arterial and venous thrombosis. J Thromb Haemost 14(8):1561–1571
Jensen MP, Karoly P, Braver S (1986) The measurement of clinical pain intensity: a comparison of six methods. Pain 27:117–126
Jiang WG, Redfern A, Bryce RP, Mansel RE (2000) Peroxisome proliferator activated receptor-γ (PPAR-γ) mediates the action of gamma linolenic acid in breast cancer cells. Prostaglandins Leukot Essent Fatty Acids 62(2):119–127
Jung JY, Kwon HH, Hong JS, Yoon JY, Park MS, Jang MY, Suh DH (2014) Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. Acta Derm Venereol 94(5):521–526
Kapoor R, Huang YS (2006) Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. Curr Pharm Biotechnol 7(6):531–534
Kast RE (2001) Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. Int Immunopharmacol 1(12):2197–2199
Kawamura A, Ooyama K, Kojima K, Kachi H, Abe T, Amano K, Aoyama T (2011) Dietary supplementation of gamma-linolenic acid improves skin parameters in subjects with dry skin and mild atopic dermatitis. J Oleo Sci 60(12):597–607
Labrousse VF, Leyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S, Bretillon L, Pallet V, Gressens P, Joffre C (2018) Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun 73:427–440
Larson KM, Roby MR, Stermitz FR (1984) Unsaturated pyrrolizidines from borage (Borago officinalis), a common garden herb. J Nat Prod 47(4):747–748
Lindqvist HM, Gjertsson I, Andersson S, Calder PC, Bärebring L (2019) Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with rheumatoid arthritis. Prostaglandins Leukot Essent Fat Acids 150:7–15
Luthria DL, Sprecher H (1994) A comparison of the specific activities of linoleate and arachidonate in liver, heart and kidney phospholipids after feeding rats ethyl linoleate-9,10,12,13-d4. Biochim Biophys Acta 1213:1–4
Makrides M, Gibson RA, McPhee AJ, Collins CT, Davis PG, Doyle LW, Simmer K, Colditz PB, Morris S, Smithers LG, Willson K (2009) Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trial. JAMA 301(2):175–182
Makrides M, Smithers LG, Gibson RA (2010) Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth. In: Importance of growth for health and development, vol 65. Karger Publishers, pp 123–136
Mhamdi B, Wannes WA, Bourgou S, Marzouk B (2009) Biochemical characterization of borage (Borago officinalis L.) seeds. J Food Biochem 33(3):331–341
Miceli A, Aleo A, Corona O, Sardina MT, Mammina C, Settanni L (2014) Antibacterial activity of Borago officinalis and Brassica juncea aqueous extracts evaluated in vitro and in situ using different food model systems. Food Control 40:157–164
Miceli A, Francesca N, Moschetti G, Settanni L (2015) The influence of addition of Borago officinalis with antibacterial activity on the sensory quality of fresh pasta. Int J Gastron Food Sci 2(2):93–97
Mifsud S (2004) Borago officinalis (common Borage). http://www.maltawildplants.com/BORG/Borago_officinalis.php. Accessed 16 October 2019
Mortensen A, Skibsted LH (1997) Real time detection of reactions between radicals of lycopene and tocopherol homologues. Free Radic Res 27(2):229–234
Namal Senanayake SP, Shahidi F (2000) Lipid components of borage (Borago officinalis L.) seeds and their changes during germination. J Am Oil Chem Soc 77(1):55–61
National Eczema Association (2019). https://nationaleczema.org/eczema/types-of-eczema/atopic-dermatitis/. Accessed 10 October 2019
Navarette R, Tang W, Ziboh VA (1992) Dietary intake of concentrated gamma-linolenic acid (GLA)-enriched oil suppresses cutaneous level of dihomo-gamma-linolenic acid (DGLA): possible in vivo inhibition of microsomal elongation of GLA to DGLA. Prostaglandins Leukot Essent Fatty Acids 46:139–144
Osakabe N, Takano H, Sanbongi C, Yasuda A, Yanagisawa R, Inoue KI, Yoshikawa T (2004) Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. Biofactors 21(1–4):127–131
Osborne JL (1999) Borage. Bee World 80(1):33–36
Pawlosky R, Barnes A, Salem N Jr (1994) Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. J Lipid Res 35:2032–2040
Pereira C, Barros L, Carvalho AM, Ferreira IC (2011) Nutritional composition and bioactive properties of commonly consumed wild greens: potential sources for new trends in modern diets. Food Res Int 44(9):2634–2640
Phinney SD, Tang AB, Thurmond DC, Nakamura MT, Stern JS (1993) Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by g-linolenic acid administration. Metabolism 42:1127–1140
Pilerood SA, Prakash J (2014) Evaluation of nutritional composition and antioxidant activity of Borage (Echium amoenum) and Valerian (Valerian officinalis). J Food Sci Technol 51(5):845–854
Puch F, Samson-Villeger S, Guyonnet D, Blachon JL, Rawlings AV, Lassel T (2008) Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. Exp Dermatol 17(8):668–674
Redden PR, Huang YS, Lin X, Horrobin DF (1995) Separation and quantification of the triacylglycerols in evening primrose and borage oils by reversed-phase high-performance liquid chromatography. J Chromatogr A 694(2):381–389
Reed GW, Leung K, Rossetti RG, VanBuskirk S, Sharp JT, Zurier RB (2014) Treatment of rheumatoid arthritis with marine and botanical oils: an 18-month, randomized, and double-blind trial. Evid Based Complement Alternat Med 2014:1–9. https://doi.org/10.1155/2014/857456
Rio-Celestino MD, Font R, de Haro-Bailón A (2008) Distribution of fatty acids in edible organs and seed fractions of borage (Borago officinalis L.). J Sci Food Agric 88(2):248–255
Robbins RJ (2003) Phenolic acids in foods: an overview of analytical methodology. J Agric Food Chem 51(10):2866–2887
Roberts MJ (2000). Edible & medicinal flowers. New Africa Books. p 8. ISBN: 9780864864673
Rocha J, Eduardo-Figueira M, Barateiro A, Fernandes A, Brites D, Bronze R, Duarte CM, Serra AT, Pinto R, Freitas M, Fernandes E (2015) Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. Basic Clin Pharmacol Toxicol 116(5):398–413
Ryan AS, Astwood JD, Gautier S, Kuratko CN, Nelson EB, Salem N Jr (2010) Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 82(4–6):305–314
Schirmer MA, Phinney SD (2007) γ-linolenate reduces weight regain in formerly obese humans. J Nutr 137(6):1430–1435
Selvi F, Coppi A, Bigazzi M (2006) Karyotype variation, evolution and phylogeny in Borago (Boraginaceae), with emphasis on subgenus Buglossites in the Corso-Sardinian system. Ann Bot 98:857–868
Sergeant S, Rahbar E, Chilton FH (2016) Gamma-linolenic acid, dihommo-gamma linolenic, eicosanoids and inflammatory processes. Eur J Pharmacol 785:77–86
Simon D, Eng PA, Borelli S, Kägi R, Zimmermann C, Zahner C, Drewe J, Hess L, Ferrari G, Lautenschlager S, Wüthrich B (2014) Gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis. Adv Ther 31(2):180–188
Sovova H, Zarevucka M, Vacek M, Stránský K (2001) Solubility of two vegetable oils in supercritical CO2. J Supercrit Fluids 20(1):15–28
Szterk A, Roszko M, Sosińska E, Derewiaka D, Lewicki PP (2010) Chemical composition and oxidative stability of selected plant oils. J Am Oil Chem Soc 87(6):637–645
Takahashi Y, Ide T, Fujita H (2000) Dietary gamma-linolenic acid in the form of borage oil causes less body fat accumulation accompanying an increase in uncoupling protein 1 mRNA level in brown adipose tissue. Comp Biochem Physiol B: Biochem Mol Biol 127(2):213–222
Tamariz J, Burgueño-Tapia E, Vázquez MA, Delgado F (2018) Pyrrolizidine alkaloids. In: The alkaloids: chemistry and biology, vol 80. Academic Press, pp 1–314
Tanaka A, Amagai Y, Oida K, Matsuda H (2015) Dihomo-γ-linolenic acid prevents the development of atopic dermatitis through prostaglandin D1 production in NC/Tnd mice. Allergy Eur JAllergy Clin Immunol 70:30–37. https://doi.org/10.1016/j.jdermsci.2015.03.010
Tasset-Cuevas I, Fernández-Bedmar Z, Lozano-Baena MD, Campos-Sánchez J, de Haro-Bailón A, Muñoz-Serrano A, Alonso-Moraga Á (2013) Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies. PLoS One 8(2):1–9. https://doi.org/10.1371/journal.pone.0056986
Thurmond DC, Tang AB, Nakamura MT, Stern JS, Phinney SD (1993) Time dependent effects of progressive g-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. Obes Res 1:118–125
USDA (2019). https://fdc.nal.usda.gov/fdc-app.html#/food-details/170481/nutrients. Accessed 10 October 2019
Vacillotto G, Favretto D, Seraglia R, Pagiotti R, Traldi P, Mattoli L (2013) A rapid and highly specific method to evaluate the presence of pyrrolizidine alkaloids in Borago officinalis seed oil. J Mass Spectrom 48(10):1078–1082
Vander Cruyssen B, Van Looy S, Wyns B, Westhovens R, Durez P, Van den Bosch F, Veys EM, Mielants H, De Clerck L, Peretz A, Malaise M, Verbruggen L, Vastesaeger N, Geldhof A, Boullart L, De Keyser F (2005) DAS28 best reflects the physician’s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment. Arthritis Res Ther 7:R1063–R1071. https://doi.org/10.1186/ar1787
Vasiljevic D, Veselinovic M, Jovanovic M, Jeremic N, Arsic A, Vucic V, Lucic-Tomic A, Zivanovic S, Djuric D, Jakovljevic V (2016) Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis. Clin Rheumatol 35(8):1909–1915
Veselinovic M, Vasiljevic D, Vucic V, Arsic A, Petrovic S, Tomic-Lucic A, Savic M, Zivanovic S, Stojic V, Jakovljevic V (2017) Clinical benefits of n-3 PUFA and ɤ-linolenic acid in patients with rheumatoid arthritis. Nutrients 9(4):1–11. https://doi.org/10.3390/nu9040325
Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282:2131–2135
Wang X, Lin H, Gu Y (2012) Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids Health Dis 11(1):25
Wang F, Miao M, Chen B, Wang R, Sun B, Ren D, Lu J (2015) Antineoplastic activity of γ-linolenic acid extract from Spirulina platensis on HepG2 cells and its inhibition effect on platelet aggregation. Food Agric Immunol 26(1):97–108
Wang Q, Cui Q, Yan C (2016) The effect of supplementation of long-chain polyunsaturated fatty acids during lactation on neurodevelopmental outcomes of preterm infant from infancy to school age: a systematic review and meta-analysis. Pediatr Neurol 59:54–61
Ward PE (2000) Potential diagnostic aids for abnormal fatty acid metabolism in a range of neurodevelopmental disorders. Prostaglandins Leukot Essent Fatty Acids 63:65–68
Wauquier F, Barquissau V, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Philippe C, Miot-Noirault E, Chardigny JM, Morio B, Wittrant Y (2012) Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis. Bone 50(2):553–561
Wettasinghe M, Shahidi F, Amarowicz R, Abou-Zaid MM (2001) Phenolic acids in defatted seeds of borage (Borago officinalis L.). Food Chem 75(1):49–56
WHO (2018). https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed 10 October 2019
Wretensjö I, Karlberg B (2003) Pyrrolizidine alkaloid content in crude and processed borage oil from different processing stages. J Am Oil Chem Soc 80(10):963–970
Zadernowski R, Naczk M, Nowak-Polakowska H (2002) Phenolic acids of borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.). J Am Oil Chem Soc 79(4):335–338
Zhang C, Yu H, Shen Y, Ni X, Shen S, Das UN (2015) Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway. Arch Med Sci 11(5):1081–1094. https://doi.org/10.5114/aoms.2015.54865
Ziboh VA, Miller CC, Cho Y (2000) Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. Am J Clin Nutr 71:361s–366s
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Tanwar, B., Goyal, A., Kumar, V., Rasane, P., Sihag, M.K. (2021). Borage (Borago officinalis) Seed. In: Tanwar, B., Goyal, A. (eds) Oilseeds: Health Attributes and Food Applications. Springer, Singapore. https://doi.org/10.1007/978-981-15-4194-0_14
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