Abstract
The human gut harbours a multifaceted and dynamic population of microorganisms, which affect human homeostasis and health. Robust network among gut microbes plays an important role in human health and disease by influencing immunity, nutrition and pathogenesis. The gut microbes are frequently exposed to antibiotics, which are used to prevent and/or treat infectious diseases. Prolonged use of antibiotics has been associated with reduced gut microbial colonization ability and their diversity. The use of antibiotics causes dysbiosis, a state that has a significant alteration in the community structure, composition and richness of the gut microbiome. Dysbiosis disrupts the gut microbial ecosystem and is associated with many diseases: diarrhoea, constipation, bloating, indigestion, irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD), obesity and diabetes. The emergence of antibiotic resistance (AMR) among commensal and pathogenic bacteria has become a major threat to public health. These commensals can acquire AMR genes (ARGs) by the mobilization/transfer from the other bacteria. Several bacteria in the gut may retain these ARGs. In this review, we discuss the effects of antibiotics on the commensal gut microbiota, as well as their impact on the human host.
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Chowdhury, G., Ramamurthy, T. (2020). Influence of Antimicrobials on the Gut Microbiota. In: Thomas, S. (eds) Antimicrobial Resistance. Springer, Singapore. https://doi.org/10.1007/978-981-15-3658-8_3
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