Abstract
Cancer has been one of the leading causes of infirmity and fatality around the world at the present time. This group of disease constitutes an immense onus on society in both economically developed and underdeveloped countries in a similar way. The emergence of cancer is because of many common factors such as the growth and aging of the population, as well as an increasing preponderance of predetermined imperiled factors such as smoking, obesity, physical idleness, and variable reproductive arrangements associated with urbanization and economic development most of which leads to stress. Currently, cancer research has been marked by a growing appreciation of the role of herbs in the cancer treatment. This is because, the current conventional cancer treatments involve synthetic chemical drugs which are often accompanied with an increased adverse events with unsatisfactory survival rate. Recently, herbal plants of tropical origin have been investigated for their anticancer activities, leaving behind the effervescence of macromolecules with much of the unexplored ethnobotanical significance of the multifarious mangrove flora and fauna. Mangrove environmental conditions are one of the toughest ecosystems on earth. Moreover, flora and fauna in such conditions are known to contain abundant bioactive compounds, such as hormones, antioxidants, fluorescent pigments, and other nutritional or pharmacologically significant compounds. Therefore, this chapter presents a brief overview of the anticancer activity of mangrove phytocompounds in bioconjugation with certain advanced therapeutic agents such as nanoparticles or nanocarriers.
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References
Abdel-Lateff AG, Konig M, Fisch KM (2002) New antioxidant hydroquinone derivatives from the algicolous marine fungus Acremonium. J Nat Prod 65:1605–1611
ACS (2016) Cancer treatment and survivorship facts and figures 2016–2017. ACS, Atlanta, pp 1–40
Akhtar MS, Swamy MK, Umar A, Sahli A, Abdullah A (2015) Biosynthesis and characterization of silver nanoparticles from methanol leaf extract of Cassia didymobotyra and assessment of their antioxidant and antibacterial activities. J Nanosci Nanotechnol 15:9818–9823
Alikunhi NM, Kandasamy K, Manivannan S (2010) Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. J Diabetes 2:97–103
Alikunhi NM, Kandasamy K, Manoharan C, Subramanian M (2011) Insulin-like antigen of mangrove leaves and its anti-diabetic activity in alloxan induced diabetic rats. Nat Prod Lett 26:1161–1166
Anusri P, Siwattra C, Pranom C, Sirichai A, Khanitha P (2014) Inhibitor effects flavonoids from stem of Derris indica of on the formation of advanced glycation end products. J Ethnopharmacol 158:437–441
Ariole CN, Akinduyite AE (2016) Antibacterial potential of indigenous red mangrove (Rhizophora racemosa) fungal endophytes and bioactive compounds identification. Int J Microbiol Mycol 4:14–24
Arunachalam C, Gayathri P (2010) Studies on bioprospecting of endophytic bacteria from the medicinal plant of Andrographis paniculata for their antimicrobial activity and antibiotic susceptibility pattern. Int J Curr Pharm Res 4:63–68
Bandaranayake WM (2002) Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wetlands Ecol Manag 10:421–452
Banker R, Carmeli S (1998) Tenuecyclamides AD, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenue. J Nat Prod 61:1248–1251
Basha SKC, Rao KRSS (2017) An intrinsic assessment of bioactive potentiality of mangroves actinomycetes. J Entomol Zoo Stud 5:20–26
Berenguer B, Sanchez LM, Quılez A, López-Barreiro M, de Haro O, Gálvez J, MartÃn MJ (2006) Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers. J Ethnopharmacol 103:194–200
Bhimb BV, Franco DA, Jose GM, Mathew JM, Joel EL (2011) Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4. Asian Pac J Trop Biomed 1:223–226
Boopathy NS, Kathiresan K (2010) Anticancer drugs from marine flora: an overview. J Oncol 2010:214186. https://doi.org/10.1155/2010/214186
Chakraborty K, Raola VK (2016) Two rare antioxidant and anti-inflammatory oleanenes from loop root Asiatic mangrove Rhizophora mucronate. Phytochemistry 135:160–168
Chakraborty T, Bhuniya D, Chatterjee M, Rahaman M, Singha D, Chatterjee BN, Datta S, Rana A, Samanta K, Srivastawa S, Maitra SK, Chatterjee M (2007) Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model. World J Gastroenterol 13:6538–6548
Chan EWC, Wong SK, Chan HT, Baba S, Kezuka M (2016) Cerbera are coastal trees with promising anticancer properties but lethal toxicity: a short review. J Chin Pharm Sci 25:161–169
Chen ZS, Pan JH, Tang WC, Chen QC, Lin YC (2009) Biodiversity and biotechnological potential of mangrove associated fungi. J For Res 20:63–72
Dai SX, Li WX, Han FF, Guo YC, Zheng JJ, Liu JQ, Wang Q, Guo YD, Li GH, Huang JF (2016) In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database. Sci Rep 6:1–9
Das SK, Samantaray D, Thatoi H (2014) Ethnomedicinal, antimicrobial and antidiarrhoeal studies on the mangrove plants of the genus Xylocarpus: a mini review. J Bioanal Biomed 2014:S12. https://doi.org/10.4172/1948-593X.S12-004
Debbab A, Aly AH, Lin WH, Proksch P (2010) Bioactive compounds from marine bacteria and fungi. Microb Biotechnol 3:544–563
De-Faria FM, Almeida ACA, Luiz F (2012) Mechanisms of action underlying the gastric antiulcer activity of the Rhizophora mangle L. J Ethnopharmacol 139:234–243
Dissanayake N, Chandrasekara U (2014) Effects of mangrove zonation and the physicochemical parameters of soil on the distribution of macrobenthic fauna in kadolkele mangrove forest, a tropical mangrove forest in Sri Lanka. Adv Ecol Res 2014:1–13
Dong BX, Wan WY, Ying H, Zi-X D, Kui H (2014) Natural products from mangrove Actinomycetes, marine drugs. Mar Drugs 12:2590–2613
Dyshlovoy SA, Madanchi R, Hauschild J, Otte K, Alsdorf WH, Schumacher U, Kalinin VI, Silchenko AS, Avilov SA, Honecker F, Stonik VA, Bokemeyer C, von Amsber G (2017) The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells. BMC Cancer 17:93. https://doi.org/10.1186/s12885-017-3085-z
Edreva A, Velikova V, Tsonev T, Dagnon S, Gurel A, Atkas L, Gesheva E (2008) Stress-protective role of secondary metabolites: diversity of functions and mechanisms. Gen Appl Plant Physiol 34:67–78
Eldeen IMS, Effendy MAW (2013) Antimicrobial agents from mangrove plants and their ndophytes. In: Mendez-Vilas A (ed) Microbial pathogens and strategies for combating them: science, technology and education. Formatex Research Centre, Spain, pp 872–882
Fardin KM, Maria C, Marx Y (2015) Antifungal potential of Avicennia schaueriana Stapf & Leech. (Acanthaceae) against Cladosporium and Colletotrichum species. Lett Appl Microbiol 61:50–57
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386
Fu P, Yang C, Wang Y et al (2012) Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strain Streptomyces sp. FMA. Org Lett 14:2422–2425
Gerwick WH, Fenical W (1981) Ichthyotoxic and cytotoxic metabolites of the tropical brown alga Stypopodium zonale (Lamouroux) papenfuss. J Org Chem 46:22–27
Giri C, Ochieng E, Tieszen LL, Zhu Z, Singh A, Loveland T, Masek J, Duke N (2011) Status and distribution of mangrove forests of the world using earth observation satellite data. Glob Ecol Biogeogr 20:154–159
Gopal V, Yoganandam GP, Sri D, Ratnam CSL (2016) Ethno medical survey on coringa mangrove forest situated at east Godavari district of Andhra Pradesh India. J Sci 6:430–434
Han LJ, Huang X, Dahse HM, Moellmann U, Fu H, Grabley S, Sattler I, Lin W (2007) Unusual naphtoquinone derivatives from the twigs of Avicennia marina. J Nat Prod 70:923–927
Hasan S, Ansari MI, Ahmad A, Mishra M (2015) Major bioactive metabolites from marine fungi: a review. Bioinformation 11:176–181
Huang Z, Cai X, Shao C, She Z, **a X, Chen Y, Yang J, Zhou S, Lin Y (2008) Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic fungus Phomopsis sp. ZSU-H76. Phytochemistry 69:1604–1608
Huang C, Lu CK, Tu MC, Chang JH, Chen YJ, Tu YH, Huang HC (2016) Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model. Oncotarget 7:35874–35893
Jha RK, Zi-Rong X (2004) Biomedical compounds from marine organisms. Mar Drugs 2:123–146
Jia L, Yu J, Yang J, Song H, Liu X, Wang Y, Xu Y, Zhang C, Zhong Y, Li Q (2009) HCV antibody response and genotype distribution in different areas and races of China. Int J Biol Sci 5:421–427
Joel EL, Bhimba BV (2012) Fungi from mangrove plants: their antimicrobial and anticancer potentials. Int J Pharm Pharm Sci 4:139–142
Kathiresan K (2010) Importance of mangroves of India. J Coastal Environ 1:11–26
Kathiresan K, Bingham BL (2001) Biology of mangroves and mangrove ecosystems. Adv Mar Biol 40:81–251
Kathiresan K, Manivannan S (2008) Bioprospecting of marine organisms for novel bioactive compounds. Sci Trans Environ Technol 1:107–120
Khajure PV, Rathod JL (2011) Potential anticancer activity of Acanthus ilicifolius extracted from the mangroves forest of Karwar, west cost of India. World J Sci Technol 1:1–6
Kim KJ, Kim MA, Jung JH (2008) Antitumor and antioxidant activity of protocatechualdehyde produced from Streptomyces lincolnensis M-20. Arch Pharm Res 31:1572–1577
Lam DM, Viet ND, Mo TT (2014) Screening for anticancer producing endophytic actinomycetes in three mangrove plant species in Nam Dinh province. J Sci Hnue 59:114–122
Li H, Huang H, Shao C, Huang H, Jiang J, Zhu J, Liu Y, Liu L, Lu Y, Li M, Lin Y, She Z (2011) Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala. J Nat Prod 74:1230–1235
Li W, Jiang Z, Shen L, Pedpradab P, Bruhn T, Wu J, Bringmann G (2015) Antiviral limonoids including khayanolides from the Trang mangrove plant Xylocarpus moluccensis. J Nat Prod 78:1570–1578
Liu S, Dai H, Makhloufi G, Heering C, Janiak C, Hartmann R, Mandi A, Kurtán T, Müller WEG, Kassack MU, Lin W, Liu Z, Proksch P (2016) Cytotoxic 14-membered macrolides from a mangrove-derived endophytic fungus, Pestalotiopsis microspora. J Nat Prod 79:2332–2340
Luesch H, Moore RE, Paul VJ, Mooberry SL, Corbett TH (2001) Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin. J Nat Prod 64:907–910
Mahmud I, Islam MK, Saha S, Barman AK, Rahman MM, Anisuzzman M, Rahman T, Al-Nahain A, Jahan R, Rahmatullah M (2014) Pharmacological and ethnomedicinal overview of Heritiera fomes: future prospects. Int Sch Res Not 2014:938543. https://doi.org/10.1155/2014/938543
Mangamuri U, Muvva V, Poda S, Krishna Naragani K, Munaganti RK, Chitturi B, Yenamandra V (2016) Bioactive metabolites produced by Streptomyces cheonanensis VUK-A from Coringa mangrove sediments: isolation, structure elucidation and bioactivity. 3 Biotech 6:63. https://doi.org/10.1007/s13205-016-0398-6
Mani KT, Kumar S, Puta Z (2012) The gastroprotective role of Acanthus ilicifolius-a study to unravel the underlying mechanism of antiulcer activity. Sci Pharm 80:701–717
Manivasagan P, Venkatesan J, Sivakumar K, Kim SK (2014) Pharmaceutically active secondary metabolites of marine actinobacteria. Microbiol Res 169:262–278
Medina RA, Goeger DE, Hills P, Mooberry SL, Huang N, Romero LI, Ortega-BarrÃa E, Gerwick WH, McPhail KL (2008) Coibamide A, a potent antiproliferative cyclic depsipeptide from the panamanian marine cyanobacterium Leptolyngbya sp. J Am Chem Soc 130:6324–6325
Mendhulkar VD, Yeragi LA, Kumar H (2017) Bioassay of vector larvaes with latex of blind eye mangrove plant Excoecaria agallocha Linn. Int J Mosq Res 4:33–36
Mohanty SK, Swamy MK, Sinniah UR, Anuradha M (2017c) Leptadenia reticulata (Retz.) Wight (Jivanti): botanical, agronomical, phytochemical, pharmacological, and biotechnological aspects. Molecules 22:E1019. https://doi.org/10.3390/molecules22061019
Moore RE (1996) Cyclic peptides and depsipeptides from cyanobacteria: a review. J Ind Microbiol 16:134–143
Neumann J, Yang Y, Kohler R, Giaisi M, Witzens-Harig M, Liu D, Krammer PH, Lin W, Li-Weber M (2015) Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR–Chk1/Chk2-regulated cell cycle arrest. Int J Cancer 137:2739–2748
Nguyen TH, Pham HV, Pham NK, Quach ND, Pudhom K, Hansen PE, Nguyen KP (2015) Chemical constituents from Sonneratia ovata Backer and their in vitro cytotoxicity and acetylcholinesterase inhibitory activities. Bioorg Med Chem Lett 25:2366–2371
Patil RC, Manohar SM, Upadhye MV, Katchi VI, Rao AJ, Mule A, Moghe AS (2011) Anti reverse transcriptase and anticancer activity of stem ethanol extracts of Excoecaria agallocha (Euphorbiaceae). Ceylon J Bio Sci 40:147–155
Patra JK, Dhal NK, Thatoi HN (2011) In vitro bioactivity and phytochemical screening of Suaeda maritima (Dumort): a mangrove associate from Bhitarkanika, India. Asian Pac J Trop Med 4:727–734
Patra JK, Das SK, Thatoi H (2014) Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala from Odisha coast of India. Chin J Integr Med 21:274–285
Plummer M, de Martel C, Vignat J, Ferlay J, Bray F, Franceschi S (2016) Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health 4:e609–e616
Prabhu VV, Guruvayoorappan C (2012) Anti-inflammatory and antitumor activity of the marine mangrove Rhizophora apiculate. J Immunotoxicol 9:341–352
Prasannan P, Lekshmi M, Jayadev A (2016) Isolation and characterization of actinomycetes from mangrove samples. Int J Curr Sci Res 2:875–884
Reddy ARK, Grace JR (2016a) Anticancer activity of methanolic extracts of selected mangrove plants. Int J Pharma Sci Res 7:3852–3856
Reddy ARK, Grace JR (2016b) Evaluation of invitro anticancer activity of selected mangrove plant extracts against MCF7 cell line. Int J Pharma Sci Res 7:12315–12318
Reza H, Haq WM, Das AK, Rahman S, Jahan R, Rahmatullah M (2011) Anti-hyperglycemic and antinociceptive activity of methanol lead and stem extract of Nypa fruticans Wrumb. Pak J Pharm Sci 24:485–488
Rudramurthy GR, Swamy MK, Sinniah UR, Ghasemzadeh A (2016) Nanoparticles: alternatives against drug-resistant pathogenic microbes. Molecules 21:836
Saad S, Taher M, Susanti D, Qaralleh H, Binti NA, Rahim A (2011) Antimicrobial activity of mangrove plant (Lumnitzera littorea). Asian Pac J Trop Med 4:523–525
Sain M, Sharma V (2013) Catharanthus roseus (an anti-cancerous drug yielding plant)-a review of potential therapeutic properties. Int J Pure App Biosci 1:139–142
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Tennekoon KH, Piyathilaka P, Thabrew I, de Silva ED (2016a) In vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant, Phoenix paludosa Roxb. Trop J Pharm Res 15:127–132
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I (2016b) Screening of fifteen mangrove plants found in Sri Lanka for in-vitro cytotoxic properties on breast (MCF-7) and hepatocellular carcinoma (HepG2) cells. Eur J Med Plants 14:1–11
Saranraj P, Sujitha D (2015) Mangrove medicinal plant: a review. Am-Eur J Toxicol Sci 7:146–156
Sarker S, Kuri KC, Chowdhury MSM, Rahman MT (2010) Mangrove: a livelihood option for coastal community of Bangladesh. Bang Res Publ J 3:1187–1192
Satapathy S, Satapathy S, Jena BK (2013) Antitumor and growth effector screen of leaf extracts of selected mangroves of Bhitarkanika, Odisha. Int J Tech Enhanc Emerg Eng Res 1:25–30
Ser HL, Palanisamy UD, Yin WF, Abd Malek SN, Chan KG, Goh BH, Lee LH (2015) Presence ofantioxidative agent, Pyrrolo [1,2-a]pyrazine-1, 4-dione, hexahydro in newly isolated Streptomyces mangrovisoli sp. Front Microbiol 6:854. https://doi.org/10.3389/fmicb.2015.00854
Shareef M, Ashraf MA, Sarfraz M (2016) Natural cures for breast cancer treatment. Saudi Pharm J 24:233–240
Sharma D, Pramanik A, Agrawal PK (2016) Evaluation of bioactive secondary metabolites from endophytic fungus Pestalotiopsis neglecta BAB-5510 isolated from leaves of Cupressus torulosa D. Don. 3 Biotech 6:210
Simlai A, Roy A (2013) Biological activities and chemical constituents of some mangrove species from Sundarban estuary. An overview. Pharmacognosy 7:170–178
Singh D, Aeri V (2013) Phytochemical and pharmacological potential of Acanthus ilicifolius. J Pharm Bioallied Sci 5:17–20
Singh AK, Ansari A, Kumar D, Sarkar UK (2012) Status, biodiversity and distribution of mangroves in India: an overview. In: Proceedings of national conference on marine biodiversity, Uttar Pradesh State Biodiversity Board, Lucknow, pp 59–67
Smitha RB, Madhusoodanan PV, Prakashkumar R (2014) Anticancer activity of Acanthus illicifolius Linn. from Chettuva mangroves, Kerala, India. Int J Bioassays 3:3452–3455
Sofia S, Teresa MVM (2016) Investigation of bioactive compounds and antioxidant activity of Excoecaria agallocha, L. Int J Pharm Sci Res 7:5062–5066
Sosovele ME, Bergmann B, Lyimo TJ, Hosea KM, Mueller BI (2012) Antimalarial activity of marine actinomycetes isolated from Dar Es Salaam mangrove sediments. Int J Res Bio Sci 2:177–181
Spalding M, Kainuma M, Collins L (2010) World atlas of mangroves. Earthscan Publisher, London, p 336
Stevenson CS, Capper EA, Roshak AK, Marquez B, Grace K, Gerwick WH, Jacobs RS, Marshall LA (2002) Scytonemin-a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflamm Res 51:112–114
Sudheer NS, Rosamma P, Singh ISB (2012) Anti-white spot syndrome virus activity of Ceriops tagal aqueous extract in giant tiger shrimp Penaeus monodon. Arch Virol 157:1665–1675
Sukumaran S, Kiruba S, Mahesh M, Nisha SR, Miller PZ, Ben CP, Jeeva S (2011) Phytochemical constituents and antibacterial efficacy of the flowers of Peltophorum pterocarpum (DC.) Baker ex Heyne. Asian Pac J Trop Med 4:735–738
Swamy MK, Sinniah UR, Akhtar MS (2015a) In vitro pharmacological activities and GC-MS analysis of different solvent extracts of Lantana camara leaves collected from tropical region of Malaysia. Evidence-Based Compl Altern Med 2015:506413. https://doi.org/10.1155/2015/506413
Swamy MK, Akhtar MS, Mohanty SK, Sinniah UR (2015b) Synthesis and characterization of silver nanoparticles using fruit extract of Momordica cymbalaria and assessment of their in vitro antimicrobial, antioxidant and cytotoxicity activities. Spectrochim Acta A 151:939–944
Swamy MK, Sudipta KM, Jayanta K, Balasubramanya S (2015c) The green synthesis, characterization, and evaluation of the biological activities of silver nanoparticles synthesized from Leptadenia reticulata leaf extract. Appl Nanosci 5:73–81
Tan LTH, Ser HL, Yin WF, Chan KG, Lee LH, Goh BH (2015) Investigation of antioxidative and anticancer potentials of Streptomyces sp. MUM256 isolated from Malaysia mangrove soil. Front Microbiol 6:1316. https://doi.org/10.3389/fmicb.2015.01316
Tao LY, Zhang JY, Liang YJ, Chen LM, Zheng LS, Wang F, Mi YJ, She ZG, To KKW, Lin YC, Fu LW (2010) Anticancer effect and structure activity analysis of marine products isolated from metabolites of mangrove fungi in South China sea. Mar Drugs 8:1094–1105
Thajuddin N (2005) Cyanobacterial biodiversity and potential applications in biotechnology. Curr Sci 89:47–57
Thatoi H, Behera BC, Mishra RR (2013) Ecological role and biotechnological potential of mangrove fungi: a review. Mycology 4:54–71
Thatoi H, Samantaray D, Das SK (2016a) The genus Avicennia, a pioneer group of dominant mangrove plant species with potential medicinal values: a review. Front Life Sci 9:267–291
Thatoi P, Kerry RG, Gouda S, Das G, Pramanik K, Thatoi H, Patra JK (2016b) Photo-mediated green synthesis of silver and zinc oxide nanoparticles using aqueous extracts of two mangrove plant species, Heritiera fomes and Sonneratia apetala and investigation of their biomedical applications. J Photochem Photobiol 163:311–318
Tomlinson PB (1986) The botany of mangroves. Cambridge University Press, Cambridge, p 413
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87–108
Uddin SJ, Jason TLH, Beattie KD, Grice ID, Tiralongo E (2011) (2S,3S)-sulfated Pterosin C, a cytotoxic sesquiterpene from the Bangladeshi mangrove fern Acrostichum aureum. J Nat Prod 74:1–4
Uddin SJ, Grice D, Tiralongo E (2012) Evaluation of cytotoxic activity of patriscabratine, tetracosane and various flavonoids isolated from the Bangladeshi medicinal plant Acrostichum aureum. Pharm Biol 50:1276–1280
Uddin SJ, Bettadapura J, Guillon P, Darren Grice I, Mahalingam S (2013) In-vitro antiviral activity of a novel phthalic acid ester derivative isolated from the Bangladeshi mangrove fern Acrostichum aureum. J Antivir Antiretrovir 5:39–144
Urones JG, Araujo MEM, Palma FB, Basabe P, Marcos IS, Moro RF, Lithgow AM, Pineda J (1992) Meroterpenes from Cystoseira usneoides II. Phytochemistry 31:2105–2109
Valentin B, Agnel D, Franco J, Merin M, Geena MJ, Elsa LJ, Thangaraj M (2012) Anticancer and antimicrobial activity of mangrove derived fungi Hypocrea lixii VB1. Chin J Nat Med 10:7780
Valli S, Sugasini SS, Aysha OS, Nirmala P, Kumar PV, Reena A (2012) Antimicrobial potential of Actinomycetesspecies isolated from marine environment. Asian Pac J Trop Biomed 2:469–473
Vannucci M (2000) What is so special about mangroves. Braz J Biol 61:599–603
Vijayakumar S, Menakha M (2015) Pharmaceutical applications of cyanobacteria-a review. J Acute Med 5:15–23
Wang J, Lu Z, Liu P, Wang Y, Li J, Hong K, Zhu W (2012) Cytotoxic polyphenols from the fungus Penicillium expansum 091006 endogenous with the mangrove plant Excoecaria agallocha. Planta Med 78:1861–1866
Ward RD, Friess DA, Day RH, MacKenzie RA (2016) Impacts of climate change on mangrove ecosystems: a region by region overview. Ecosyst Health Sust 2:e01211
Webber M, Calumpong H, Ferreira B, Granek E, Green S, Ruwa R, Soares M (2016) Mangroves Chapter 48. In United Nations, Treaty Series 996:1–18
Wei PH, Wu SZ, Mu XM (2015) Effect of alcohol extract of Acantus ilicifoius L. on anti-duck hepatitis B virus and protection of liver. J Ethnopharmacol 160:1–5
Wei-Yan QI, Na OU, **ao-Dong WU, Han-Mei XU (2016) New arbutin derivatives from the leaves of Heliciopsis lobata with cytotoxicity. Chin J Nat Med 10:1–6
Wenqiang G, Dan L, Jixing P, Tianjiao Z, Qianqun G, Dehai L (2015) Penicitols A−C and penixanacid A from the mangrove-derived Penicillium chrysogenum HDN11-24. J Nat Prod 78:306–310
WHO (2017) Cancer fact sheet 2017, France (http://www.who.int/mediacentre/factsheets/fs297/en/; Accessed on 19th May 2017)
Wibowo M, Prachyawarakorn V, Aree T, Mahidol C, Ruchirawat S, Kittakoop P (2016) Cytotoxic sesquiterpenes from the endophytic fungus Pseudolagarobasidium acaciicola. Phytochemistry 122:126–138
**e G, Zhu X, Li Q, Gu M, He Z, Wu J, Li J, Lin Y, Li M, She Z, Yuan J (2010) SZ-685C, a marineanthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway. Brit J Pharmacol 159:689–697
Xu DB, Ye WW, Han Y, Deng ZX, Hong K (2014) Natural products from mangrove Actinomycetes. Mar Drugs 12:2590–2613
Yang Y, Zhang Y, Liu D, Li-Weber M, Shao B, Lin W (2015) Dolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor activities. Fitoterapia 103:277–282
Yin S, Can CQ, Wang XN, Lin LP, Ding J, Yue J (2006) Xylogranatins A-D: novel tetra-nortriterpenoids with an unusual 9, 10-secoscaffold from marine mangrove Xylocarpus grantum. Org Lett 8:4935–4938
Yin S, Wang XN, Fan LLP, Ding J, Yue JM (2007) Limonoids from the seeds of the marine mangrove Xylocarpus granatum. J Nat Prod 70:682–685
Yin SY, Wei WC, Jian FY, Yang NS (2013) Therapeutic applications of herbal medicines for cancer patients. Evidence-Based Compl Altern Med 2013:302426. https://doi.org/10.1155/2013/302426
Yuan G, Hong K, Lin H (2013) Newazalomycin F analogs from mangrove Streptomyces sp. 211726 with activity against microbes and cancer cells. Mar Drugs 11:817–829
Yue Q, Gao G, Zou G, Yu H, Zheng X (2017) Natural products as adjunctive treatment for pancreatic cancer: recent trends and advancements. Biomed Res Int 2017:8412508. https://doi.org/10.1155/2017/8412508
Zang LY, Wei W, Guo Y, Wang T, Jiao RH, Ng SK, Tan RX, Ge HM (2012) Sesquiterpenoids from the mangrove-derived endophytic fungus Diaporthe sp. J Nat Prod 75:1744–1749
Zhou ZF, Taglialatela-Scafati O, Liu HL, Gu YC, Kong LY, Guo YW (2014) Apotirucallane protolimonoids from the Chinese mangrove, Xylocarpus granatum Koenig. J Fitoterapia 97:192–197
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Kerry, R.G., Pradhan, P., Das, G., Gouda, S., Swamy, M.K., Patra, J.K. (2018). Anticancer Potential of Mangrove Plants: Neglected Plant Species of the Marine Ecosystem. In: Akhtar, M., Swamy, M. (eds) Anticancer plants: Properties and Application. Springer, Singapore. https://doi.org/10.1007/978-981-10-8548-2_13
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