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A Potential Role of Hypoxia-Inducible Factor-1 (HIF-1) in Esophageal Cancer

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Role of Transcription Factors in Gastrointestinal Malignancies

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Abstract

Hypoxia-inducible factor-1 (HIF-1) is a regulatory protein, mainly responsible for maintaining oxygen homeostasis in response to reduced oxygen concentration in cells and tissues. The protein is a heterodimer which consists of subunit HIF-α and HIF-β. It is an important transcription factor involved in the transcriptional regulation of many genes related to embryonic development, metabolism, cell proliferation, angiogenesis, metastasis, and response to radiation therapy, making it an important regulator in most cancer therapies. Esophageal cancer (EC) is not a well-studied and a poorly understood cancer. It is highly aggressive in nature with poor survival rate. Its mortality rate ranks sixth among all cancers. Overexpression studies of HIF-1 in correlation with other target gene expressions revealed its role in both upregulation and downregulation of certain molecules in particular cancer types. Considering all parameters, HIF-1 inhibitor could present a potential approach to cancer therapy. This chapter summarizes the potential roles of HIF-1α in cell cycle, proliferation, apoptosis, and metastasis and future perspectives in targeting esophageal cancer for develo** novel anticancer therapies.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Author information

Authors and Affiliations

  1. National Institute of Virology, Pune, India

    Shakuntala Mahilkar & Prudhvi Lal Bhukya

  2. International Crops Research Institute for Semi-Arid Tropics (ICRISAT), Hyderabad, India

    L. S. Bhargavi

Authors
  1. Shakuntala Mahilkar
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  2. Prudhvi Lal Bhukya
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  3. L. S. Bhargavi
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Corresponding author

Correspondence to Prudhvi Lal Bhukya .

Editor information

Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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© 2017 Springer Nature Singapore Pte Ltd

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Mahilkar, S., Bhukya, P.L., Bhargavi, L.S. (2017). A Potential Role of Hypoxia-Inducible Factor-1 (HIF-1) in Esophageal Cancer. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_7

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