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Role of Sp1 Transcriptional Factor in Gastrointestinal Carcinogenesis

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Role of Transcription Factors in Gastrointestinal Malignancies

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Abstract

Sp1 protein binds to GC/GT-rich promoter elements through zinc finger motifs present at their C-terminal domains and regulates expression of multiple genes in normal tissues and tumors. Sp1 protein plays a critical role in the growth and metastasis of gastrointestinal cancers by regulating expression of cell cycle genes and VEGF. However, Sp1 is involved much in growth-related signal transduction pathways, and its overexpression has both positive and negative effects on proliferation of cells. In addition to growth control, Sp1 is intricate in apoptosis and angiogenesis; therefore, Sp1 is involved in several aspects of tumorigenesis. Consistent with a role of Sp1 in cancer, it interacts with oncogenes and tumor suppressors and alters their expression. Effects of changes in Sp1 factor are context-dependent and are paradoxical. Sp1 proteins have been recognized as an essential cancer drug target.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Authors and Affiliations

  1. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    A. M. V. N. Prathyusha & Pallaval Veera Bramhachari

  2. Yashwnatrao Chavan College of Science, Karad, Maharashtra, India

    Renuka Nawadkar

  3. Yashwnatrao Chavan Law College, Pune, India

    Renuka Nawadkar

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  1. A. M. V. N. Prathyusha
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  2. Renuka Nawadkar
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  3. Pallaval Veera Bramhachari
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Correspondence to Pallaval Veera Bramhachari .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Prathyusha, A.M.V.N., Nawadkar, R., Bramhachari, P.V. (2017). Role of Sp1 Transcriptional Factor in Gastrointestinal Carcinogenesis. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_13

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