Abstract
CD8 positive T cells (CD8 T cells) are immune cells that are crucial in controlling viral infections and the eradication of tumor cells by processes that are primarily dependent on their cytotoxic activities. To exert their effects and due to the consequent strong cytotoxicity, the activation and differentiation of naive CD8 T cells to cytotoxic T lymphocytes (CTLs) are precisely regulated during immune responses. CD8 T cells are primed by antigen-presenting dendritic cells in the presence of permission for activation/differentiation to CTLs. Recent studies have unveiled that Notch signaling gives a license to CD8 T cells to fully activate and become effector cells during priming. In this review, we discuss the recent progresses in the study of the regulation of the activation and function of CD8 T cells by Notch signaling.
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Maekawa, Y., Ikeda, T., Srinontong, P. (2017). Notch Controls the Differentiation and Function of Cytotoxic CD8 T Cells. In: Yasutomo, K. (eds) Notch Signaling. Springer, Singapore. https://doi.org/10.1007/978-981-10-4971-2_2
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DOI: https://doi.org/10.1007/978-981-10-4971-2_2
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