Abstract
The prefrontal cortex (PFC) and the striatum have mutual connections through direct and indirect pathways. It is known that neurons in the two areas encode reward information. However, it remains elusive that how interaction between PFC and striatum is modulated with reward. To investigate this issue, we used multielectrodes to record local field potentials (LFPs) simultaneously from the lateral PFC (LPFC) and the striatum when a monkey performed a sequential paired-association task with different amounts of reward (a large reward or a small reward). Granger causality analysis revealed that the strength of functional connectivity from the LPFC to the striatum was greater in small than in large reward trials, and greater in correct trials than in erroneous trials. Our results suggest that the LPFC has strong interaction with the striatum during reward processing, which may regulate monkey’s behavior correctly.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Haber, S.N., Kim, K.S., Mailly, P., Calzavara, R.: Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning. J. Neurosci. 26, 8368–8376 (2006)
Alexander, G.E., Delong, M.R., Strick, P.L.: Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 357–381 (1986)
Assad, W.F., Eskandar, E.N.: Encoding of both positive and negative reward prediction errors by neurons of the primate lateral prefrontal cortex and caudate nucleus. J. Neurosci. 31, 17772–17787 (2011)
Watanabe, M.: Reward expectancy in primate prefrontal neurons. Nature 382, 629–632 (1996)
Hikosaka, O.: Basal ganglia mechanisms of reward-oriented eye movement. Ann. N. Y. Acad. Sci. 1104, 229–249 (2007)
Pan, X., Sawa, K., Tsuda, I., Tsukada, M., Sakagami, M.: Reward prediction based on stimulus categorization in primate lateral prefrontal cortex. Nat. Neurosci. 11, 703–712 (2008)
Seth, A.K.: A MATLAB toolbox for Granger causal connectivity analysis. J. Neurosci. Methods 186, 262–273 (2010)
Samejima, K., Ueda, Y., Doya, K., Kimura, M.: Representation of action-specific reward values in the striatum. Science 310, 1337–1340 (2005)
Fries, P.: A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn. Sci. 9, 474–480 (2005)
Acknowledgments
This work was supported by Grant-in-Aid for Scientific Research on Innovative Areas (4303) from MEXT (Ministry of Education, Culture, Sports, Science and Technology) of Japan (http://decisions.naist.jp/index.html). It is supported by National Natural Science Foundation of China (No. 11232005, No. 11472104) and sponsored by Shanghai Pujiang Program (No. 13PJ1402000).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Science+Business Media Singapore
About this paper
Cite this paper
Pan, X., Wang, R., Sakagami, M. (2016). Causal Interaction Between Prefrontal Cortex and Striatum Estimated by Granger Causality. In: Wang, R., Pan, X. (eds) Advances in Cognitive Neurodynamics (V). Advances in Cognitive Neurodynamics. Springer, Singapore. https://doi.org/10.1007/978-981-10-0207-6_28
Download citation
DOI: https://doi.org/10.1007/978-981-10-0207-6_28
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-0205-2
Online ISBN: 978-981-10-0207-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)