Abstract
Arsenic is one of the few identified human carcinogens that has yet to be shown to cause cancer in rodents (IARC, 1980,1990). Because there is no rodent model that can be used to provide information on the levels of arsenic that can cause cancer (at least in rodents), the use of human data has been emphasized in the risk assessment of arsenic exposure. The human epidemiological studies that have demonstrated the connection between As exposure and cancer have been done in non-US populations and at exposure levels much higher than those seen in the US. It would be desirable to identify a sensitive biomarker that might detect biological damage (of the type seen in the etiology of cancer) at levels of As that are seen in the US (as well as in other parts of the world). In selecting biological biomarkers that might be used, it is important to consider both the types of biological damage that As (and its metabolites) might induce and the ability of the proposed biomarker(s) to respond to high levels of As exposure.
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© 1997 Springer Science+Business Media Dordrecht
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Moore, M.M., Harrington-Brock, K., Cabrera, M. (1997). Biological effects of arsenic exposure—integration of in vitro genotoxicity data with human biomarker data. In: Abernathy, C.O., Calderon, R.L., Chappell, W.R. (eds) Arsenic. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5864-0_26
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DOI: https://doi.org/10.1007/978-94-011-5864-0_26
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