Abstract
It will be impossible to deal at length with both the full natural history and demography of primary biliary cirrhosis in this short space. This will, therefore, be a review in three parts. The first will examine what we know about the early natural history of PBC and is intended to be read in conjunction with Chapter 9 by W. R. Kim and E. R. Dickson on Natural History Models of Primary Biliary Cirrhosis which will focus on the later clinical course of the disease. The second part will be a brief critical review of what we know of the world-wide distribution of PBC. In the third part, the preliminary results of a major case-finding study of the epidemiology of PBC in northeastern England will be described. This will include information about the presentation and natural history of 770 patients, prevalent and incident, in a strict geographical area between the years 1987 and 1994 with follow-up data for a median of 6.3 years.
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James, O.F.W. (1998). Natural history and demography of primary biliary cirrhosis. In: Lindor, K.D., Heathcote, E.J., Poupon, R. (eds) Primary Biliary Cirrhosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4884-9_1
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DOI: https://doi.org/10.1007/978-94-011-4884-9_1
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