Abstract
The best-studied routes of isoprenoid biosynthesis are those of vertebrates, where terpenes and terpenoids are generally produced via the mevalonate metabolism. Throughout this book we will refer to it as the mevalonate-dependent route (MAD route). The biosynthesis of mevalonic acid, which is their precursor, is governed by at least four different enzymes: acetyl-CoA thiolase, HMG-CoA synthase, HMG-CoA cyclase and HMG-CoA reductase. The latter enzyme that reduces ß-hydroxy-ß-methylglutaryl CoA to mevalonic acid (MVA) (Box 2.1) is a key enzyme in the production of MVA and isoprenoid groups.
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© 2000 Springer Science+Business Media Dordrecht
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Harrewijn, P., van Oosten, A.M., Piron, P.G.M. (2000). Production of terpenes and terpenoids. In: Natural Terpenoids as Messengers. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0767-2_2
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DOI: https://doi.org/10.1007/978-94-010-0767-2_2
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3822-5
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