Abstract
There has been a marked resurgence of interest in the general topic of immune complex glomerulonephritis in the past two to three years. Several factors account for this phenomenon, including the recent availability of assays for circulating immune complexes in human renal disease, but the major reason is that several basic observations made in the laboratory have prompted important revisions in the way we now think about immune complex nephritis. These changes have occurred particularly in two areas. First, there have been important changes in the concepts of how these granular deposits form in glomeruli. Secondly, there have also been some new discoveries with respect to the mechanisms by which these deposits mediate glomerular injury. This presentation will review some of these observations and give you some idea, at least from our prospective, of current thinking about the pathogenesis of immune complex glomerulonephritis.
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© 1981 Martinus Nijhoff Publishers, The Hague
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Couser, W.G., Salant, D.J., Madaio, M.P., Adler, S. (1981). Mechanisms of Immune Complex Injury. In: Gruskin, A.B., Norman, M.E. (eds) Pediatric Nephrology. Developments in Nephrology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8319-9_4
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DOI: https://doi.org/10.1007/978-94-009-8319-9_4
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