Abstract
Babesiosis is a tick-transmitted disease of animals characterized by pyrexia, anemia, occasionally hemoglobinuria, and the presence of infecting protozoa in the host’s erythrocytes [1]. Losses due to babesiosis may be higher than 50% when susceptible cattle are introduced into endemic areas of the disease. Animals which survive the acute phase of the disease remain carries of the agent for variable periods of time. Accordingly, two categories of infection are recognized being babesiosis and babesiasis. Babesiosis refers to the period when there is rapid growth and multiplication of the parasite and there are clinical signs of disease, while babesiasis encompasses the latent infections observed in animals which have recovered from the clinical disease and in newborn animals passively immunized via colostrum. Other occasionally used synonymous terminologies for babesiosis are: Texas cattle tick fever, prioplasmosis, tick fever, red water and tristesa.
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Ristic Miodrag and Kreier JP: Babesiosis, Academic Press, Publishers, New York, NY, 1981.
Ristic Miodrag and Healy GR: Babesiosis. In: Parasitic Zoonoses (L. Jacobs, P. Arambulo, Eds.) CRC Press, Inc., Boca Raton, Florida, 1982, pp. 151–165.
Friedhoff KT: Morphologic Aspects of Babesia in the Tick. In: Babesiosis. M Ristic and JP Kreier, Eds. Academic Press, Publishers, New York, NY, 1981. pp. 143–169.
Rudzinskia MA: Morphologic Aspects of Host-Cell-Parasite Relationships in Babesiosis. In: Babesiosis. M Ristic and JP Kreier, Eds. Academic Press, Publishers, New York, NY 1981. pp. 87–141.
Gray JS, DeVos AJ: Studies on a bovine Babesia transmitted by Hyalomma marginatum rufipes. (Koch, 1844) Onderst J Vet Res 48:215–223,1981.
Arnold RM, Asselbergs M: Tick borne diseases. World Animal Review 40:23–29,1981.
Babes V: Sur l’Hemoglobinuria Bacterienne Du Boeuf. C.R. Bebd. Seances Adac Sci Paris 107:692–694, 1888.
Smith T and Kilbourne FL: Investigation into the Nature, Causation and Prevention of Texas or Southern Cattle Fever. US Department Agri Bur Anim Ind Bull 7:1–301, 1893.
Erp EE, Gravely SM, Smith RD, Ristic M, Osorno BM and Carson CA: Growth of Babesia bovis in Bovine Erythrocyte Cultures. Am J Trop Med Hyg 27:1061–1064,1978.
Erp EE, Smith RD, Ristic M and Osorno BM: ContinuousIn vitro Cultivation of Babesia bovis. Am J Vet Res 41:1141–1142, 1980.
Levy MG and Risic M: Babesia bovis: Continuous Cultivation in Microaerophilous Stationary Phase Culture. Science. 207 (No. 4426): 1218–1220, 1980.
Ristic M and Levy MG: A New Era of Research Toward Solution of Bovine Babesiosis. In: Babesiosis. M Ristic and JP Kreier, Eds., Academic Press, Publishers, New York, NY 1981. pp. 509–544.
Wright IG: Biochemical Characteristics of Babesia and Physicochemical Reactions in the Host. In: Babesiosis. M Ristic and JP Kreier, Eds., Academic Press, Publishers, New York, NY, 1981. pp. 171–205.
Aikawa M, Rabbege J, Udeinya I and Miller LH: Electron microscopy of knobs in P. falci- parum-infected erythrocytes. J Parasitology 62:435–437, 1983.
Aikawa M, Rabbege J, Ristic M and Miller LH: Structural Alterations of the Membrane of Erythrocytes Infected with Babesia bovis. In Press. J Trop Med and Hyg 1984.
Callow LT: Vaccination Against Bovine Babesiosis. Adv Exp Med Biol 93:121–149,1977.
Carson CA, Phillips RS: Immunologic responses of the vertebrate host to Babesia. In: Babesiosis. M Ristic and JP Kreier, Eds., Academic Press, New York, NY, 1981, pp. 411–443.
Goff WL, Wagner GG, Craig TM, Long RF: The bovine immune response to tick derived Babesia bovis infection: Serological studies of isolated immunoglobulins. Vet Parasit 11:109–120, 1982.
Mahoney DF and Wright EG: Babesia argentina. Immunization of Cattle with a Killed Antigen Against Infection with a Heterologous Strain. Vet Parasitol 2:273–282,1976.
Kuttler KL, Johnson LW: Immunization of cattle with a Babesia bigemia antigen in Freund’s complete adjuvant. Am J Vet Res 41:536–538, 1980.
Callow LL, McGregor W, Parker RJ, Dalgliesh RJ: Immunity of cattle to Babesia bigemia following its elimination from the host, with observations on antibody levels detected by indirect fluorescent antibody test. Austr Vet J 50:12–15, 1974.
Mahoney DG: Bovine Babesiosis: The passive immunization of calves against Babesia argentina with special reference to the role of complement fixing antibodies. Exp Parasit 20:119–124,1967.
Weisman J, Goldman M, Mayer E, Pipano E: Passive transfer to newborn calves of maternal antibodies against Babesia bigemina and Babesia berbera. Refuah Vet 57:108–113, 1974.
Dwivedi SK, Gautam OP: Experimental studies on passive immunization against Babesia bigemina infection in calves. Indian J Anim Sci 50:169–172, 1980.
Ristic M, Smith RD, Kakoma I: Characterization of Babesia Antigens Derived from Cell Cultures and Ticks. In: Babesiosis. M Ristic and JP Kreier, Eds., Academic Press, New York, NY 1982. pp. 337–380.
Montenegro-James S, James MA, Ristic M: Localization of culture-derived solubleBabesia bovis antigens in the infected erythrocytes. Vet Parasitology 13:311–316,1983.
James MA, Levy MG and Ristic M: Isolation and Partial Characterization of Culture-derived Soluble Babesia bovis Antigens. Infec & Immun 31:358–361, 1981.
Ristic Miodrag: Babesiosis. In: Disease of Cattle in the Tropics. M Ristic and Ian Mclntyre, Eds. Martinus Nijhoff Publishers, Hague, Netherlands, 1981. pp. 443–468.
Montealegre F, Levy MG, Ristic M: In vitro secretory activity of bovine blood mononuclear phagocytes and its effect on the growth of Babesia bovis. (Abstract). Proc 2nd Int Conf Malaria and Babesiosis, Sept. 18–22, 1983, Annecy, France, p. 7.
Kahl LP, Anders RF, Rodwell BJ, Timms P and Michell GF: Variable and Common Antigens of Babesia bovis Parasites Differing in Strain and Virulence. J Immunology, 129:1700–1705,1982.
Kahl LP, Michell GF, Dalglish RH, Stewart NP, Rodwell BJ, Mellors LT, Timms P, Callow LL: Babesia bovis: Proteins of virulent and avirulent parasites passaged through ticks and splenec- tomized or intact calves. Exp Parasitology 56:222–236, 1983.
Timms P, Dalgliesh RJ, Barry DN, Dimmock CK, Rodwell BJ: Babesia bovis: Comparison of culture-derived parasites, non-living antigen and conventional vaccine in the protection of cattle against heterologous challenge. Austr Vet J 60:75–77, 1983.
Montenegro James S, Leon E, Lopez R and Toro M: Heterologous Protection in Bovine Babesiosis Using a Culture-derived Vaccine. (Abstract). Proc 2nd Int Conf Malaria and Babesiosis, Sept 18–22, 1983, Annecy, France, p. 124.
Mahoney DF, Kerr JD, Goodger BV, Wright IG: The Immune Response of Cattle to Babesia bovis (syn. B. argentina). Studies on the Nature and Specificity of Protection. Int J Parasitol 9:297–306, 1979.
Mahoney DF, Mirre GB: Babesia argentina: The infection of splenectomized calves with extracts of larval ticks (Boophilus microplus). Res Vet Sci 16:112–114, 1974.
Ronald NC, Cruz D: Transmission of Babesia bovis, using undifferentiated embryonic cells from Boophilus microplus tick eggs. Am J Vet Res 42:544–545, 1981.
Morzaria SP and Young AS: Identificaton of Babesia bigemia in the Tick Boophilus decoloratus by the Indirect Fluorescent Antibody Technique. Res Vet Sci 23:55–58,1977.
Irvin AD, Brocklesby DW, Purnell RE: Radiation and isotopic techniques in the study and control of piroplasms of cattle: A review. Vet Parasit 5:17–28, 1979.
Wright IG, Mahoney DF, Mirre GB, Goodger BV, Kerr JD: The irradiation of Babesia bovis. II. The immunogenicity of irradiated blood parasites for intact cattle and splenectomized calves. Vet Immunol Immunopathol 3:591–601, 1982.
Wright IG, Mirre GB, Mahoney DF, Goodger BV: Failure of Boophilus microplus to transmit irradiated Babesia bovis. Res Vet Sci 34:124–125, 1983.
Purnell RE, Brocklesby DW, Stark AJ: Protection of Cattle against Babesia major by the Inoculation of Irradiated Piroplasms. Res Vet Sci 25:388–390, 1978.
Mahoney DF and Wright IG: Babesia argentina: Immunization of cattle with a killed antigen against infection with a heterologous strain. Vet Parasitology, 2:273–282,1976.
Mahoney DF and Goodger BV: Babesia argentina: Immunogenicity of Plasma from Infected Animals. Exp Parasitol 52:71–85, 1972.
Mahoney DF, Wright IG and Goodger BV: Bovine babesiosis: The immunization of cattle with fractions of erythrocytes infected with Babesia bovis (syn. B. argentina). Vet Immun and Immunopath 2:145–156, 1981.
Wright IG, White M, Tracey-Patte PD, Donaldson RA, Goodger BV, Waltisbuhl DJ and Mahoney DF: Babesia bovis: Isolation of a protective antigen by using monoclonal antibodies. Inf and Immun 41:244–250, 1983.
Sibinovic KH: Immunogenic properties of purified antigens isolated from the serum of horses, dogs and rats with acute babesiosis. PhD Thesis, University of Illinois, Urbana, IL 61801,1966.
Sibinovic KH, Sibinovic S, Ristic M and Cox HW: Immunogenic properties of babesial serum antigens. J Parasitol 53:1121–1129, 1967.
Sibinovic KH, Milar R, Ristic M and Cox HW: In vivo and in vitro effects of serum antigens of babesial infection and their antibodies on parasitized and normal erythrocytes. Ann Trop Med Parasitol 63:327–336, 1969.
Gravely SM, Smith RD, Erp EE, Conto, GJ, Aikawa M, Osorno MB and Ristic M: Bovine Babesiosis. Partial Purification and Characterization of Blood Culture-derived Babesia bovis. Int J Parasitol 9:591–598, 1979.
Levy MG, Clabaugh G, Ristic M: Age Resistance in Bovine Babesiosis: Role of blood factors in resistance to Babesia bovis. Inf and Immun 37:1127–1131, 1982.
Timms P, Stewart NP, Barry DN, Dalgliesh RJ: NonlivingBabesia bovis vaccines from culture. How good are they? (Abstract). Proc 2nd Int Conf Malaria and Babesiosis, Sept. 18–22, 1983, Annecy, France, p. 109.
Kuttler KL, Levy MG, James MA, Ristic M: Efficacy of a nonviable culture derived Babesia bovis vaccine. Am J Vet Res 43:281–284, 1982.
Kuttler KL, Levy MG, Ristic M: Cell culture-derived Babesia bovis vaccine: Sequential challenge exposure of protective immunity during a 6 month postvaccination period. Am J Vet Res 44:1456- 1459, 1983.
Kuttler KL, Levy MG, Ristic M: Efficacy of cell culture-derived soluble Babesia bovis vaccines in the prevention of acute babesiosis. (Abstract). Proc 2nd Int Conf Malaria and Babesiosis, Sept. 18–22, 1983, Annecy, France, p. 108.
Smith RD, Carpenter J, Cabrera A, Gravely SM, Erp EE, Osorno M, Ristic M: Bovine Babesiosis: Vaccination against tick-borne challenge exposure with culture-derived Babesia bovis immunogens. Am J Vet Res 40:1678–1682, 1979.
Smith RD, James MA. Ristic M, Aikawa M, Vega CA: Bovine Babesiosis: Protection of cattle with culture-derived soluble Babesia bovis antigen. Science 212:335–338, 1981.
James MA, Kuttler KL, Levy MG, Ristic M: Antibody kinetics in response to vaccination against Babesia bovis. Am J Vet Res 42:1999–2001, 1981.
Laurent N, Moreau Y, Levy MG, Ristic M: A vaccine against canine babesiosis using a soluble antigen derived from cell culture of Babesia canis. (Abstract). Proc 2nd Int Conf Malaria and Babesiosis, Sept. 18–22, 1983, Annecy, France, p. 106.
Moreau Y: Vaccines Antibabesiens: Les contraintes industrielles. (Abstract). Proc 2nd Int Conf Malaria and Babesiosis, Sept. 18–22, 1983, Annecy, France, p. 121.
Molinar E, James MA, Kakoma I, Holland CJ, Ristic M: Antigenic and immunogenic studies on cell culture-derived Babesia canis. Vet Parasit 10:29–40, 1982.
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© 1984 Martinus Nijhoff Publishers, Dordrecht
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Ristic, M. (1984). Research on babesiosis vaccines. In: Ristic, M., Ambroise-Thomas, P., Kreier, J. (eds) Malaria and Babesiosis. New Perspectives in Clinical Microbiology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6042-8_7
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DOI: https://doi.org/10.1007/978-94-009-6042-8_7
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