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Autologous Bone Marrow Transplantation in Acute Nonlymphocytic Leukemia a Study of Ex Vivo Marrow Treatment with 4-Hydroperoxycyclophosphamide

  • Chapter
Minimal Residual Disease in Acute Leukemia 1986

Part of the book series: Developments in Oncology ((DION,volume 45))

Abstract

Current intensive chemotherapeutic regimens for the treatment of acute nonlymphocytic leukemia (ANLL) result in a substantial proportion of patients who enter prolonged first remissions and who may ultimately be cured of their leukemia (1–3). However, patients who experience hematologic relapses of ANLL have an extremely poor prognosis and a minimal chance for leukemia-free survival. Allogeneic bone marrow transplantation (BMT) in such patients provides an opportunity for cure, although the risks of graft-versus-host disease (GVHD) and opportunistic infections, notably viral interstitial pneumonitis, account for most of the mortality after allogeneic BMT (4–7). Furthermore, 60–75% of patients who are otherwise suitable allogeneic BMT candidates lack related MHC-matched donors, and allogeneic BMT is generally not feasible in patients over 40 years of age because of the high mortality associated with transplant-related complications (7–9).

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Authors
  1. A. M. Yeager
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  2. H. Kaizer
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  3. H. G. Braine
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  4. M. Colvin
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  5. S. D. Rowley
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  6. R. Saral
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  7. D. J. Fuller
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  8. R. F. Ambinder
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  9. W. H. Burns
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  10. S. May
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  11. L. Sensenbrenner
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  12. R. K. Stuart
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  13. G. B. Vogelsang
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  14. J. R. Wingard
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  15. G. W. Santos
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Editor information

Editors and Affiliations

  1. The Dr. Daniël den Hoed Cancer Center, P.O. Box 5201, 3008 AE, Rotterdam, The Netherlands

    Anton Hagenbeek MD, PhD  & Bob Löwenberg MD, PhD  & 

  2. Radiobiological Institute TNO, P.O. Box 5815, 2280 HV, Rijswijk, The Netherlands

    Anton Hagenbeek MD, PhD

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© 1986 Martinus Nijhoff Publishers, Dordrecht

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Yeager, A.M. et al. (1986). Autologous Bone Marrow Transplantation in Acute Nonlymphocytic Leukemia a Study of Ex Vivo Marrow Treatment with 4-Hydroperoxycyclophosphamide. In: Hagenbeek, A., Löwenberg, B. (eds) Minimal Residual Disease in Acute Leukemia 1986. Developments in Oncology, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4273-8_22

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  • DOI: https://doi.org/10.1007/978-94-009-4273-8_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8398-0

  • Online ISBN: 978-94-009-4273-8

  • eBook Packages: Springer Book Archive

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