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Secondary Flow and Atherogenesis

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Role of Blood Flow in Atherogenesis

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Abstract

Hemodynamic factors appear to affect atherosclerosis. Secondary flow in the aorta was studied by subjecting rabbits to constant pressure perfusion fixation and observing endothelial arrangement by scanning electron microscopy.

Endothelial orientation is oblique in a lateral-medical direction on the dcrsal and ventral sides in the ascending, arch and descending segments. The direction of blood flow in these regions is oblique. This oblique flow is thought to be the result of longitudinal flow and secondary flow. The oblique orientation of the endothelial cells suggests the existence of secondary flow.

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References

  1. Moro A., Studies of relationship between endothelial arrangement of rabbit aorta and aortic blood flow. Tokyo Jikei Medical Journal. 100 895–906. 1985.

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  2. Dean W.R., Note on the motion of a fluid, in a curved pipe. Phil. Mag.7, 208–223 1927.

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  3. Flaherty J.T., et.al Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events. Circ.Res. 30 23–33, 1972.

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  4. Dewey C.F.Jr. Effects of fluid flow on living vascular cells. J.Bioch.Engng. 106 31–35, 1984.

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Author information

Authors and Affiliations

  1. The Fourth Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105, Japan

    N. Ohyama, A. Nishiyama & T. Okamura

Authors
  1. N. Ohyama
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  2. A. Nishiyama
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  3. T. Okamura
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Editor information

Editors and Affiliations

  1. Department of Pathology, Yamanashi Medical College, Tamaho, 409-38, Japan

    Yoji Yoshida

  2. Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan

    Takami Yamaguchi

  3. Physiological Flow Studies Unit, Imperial College, London, SW7 2AZ, England

    Colin G. Caro

  4. Department of Pathology, University of Chicago, Chicago, IL, 60637, USA

    Seymour Glagov

  5. Biomechanics Laboratory and School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0405, USA

    Robert M. Nerem

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© 1988 Springer-Verlag Tokyo

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Ohyama, N., Nishiyama, A., Okamura, T. (1988). Secondary Flow and Atherogenesis. In: Yoshida, Y., Yamaguchi, T., Caro, C.G., Glagov, S., Nerem, R.M. (eds) Role of Blood Flow in Atherogenesis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68399-5_8

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  • DOI: https://doi.org/10.1007/978-4-431-68399-5_8

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68401-5

  • Online ISBN: 978-4-431-68399-5

  • eBook Packages: Springer Book Archive

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