Summary
AKR/J mice show a high incidence of spontaneous virus-induced T cell leukemiaat the age of 6-12 months, and a number of factors are involved in the high susceptibility to leukemiadevelopment. The present study was designed to examine whether a combination of interleukin2 (IL-2), which has a strong immunostimulatingpotential, and bone marrow transplantation(BMT) from allogeneic C3H/HeJ mice sensitive to the virus and allogeneicCBA/J mice resistant to the virus could induce resistance against the developmentof spontaneous leukemiaand exacerbate graft-versus-host disease (GVHD). Our data suggested that BMT from H-2 compatiblemice that did not possess a resistant gene for virus-induced leukemiaand a combined use of IL-2 after BMT could partially prevent the developmentof spontaneous leukemiain chimericAKR/J mice. The GVHD observed in chimeric mice was not enhanced by the administrationof IL-2.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
McEndy DP, Boon MC, Furth J. On the role of thymus, spleen, and gonads in the development of leukemia in a high-leukemia stock of mice. Cancer Res 1944; 4: 377.
Yasumizu R, Hiai H, Sugiura K, et al. Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice. J Immunol 1988; 141: 2181.
Pollard M, Truitt RL. Allogeneic bone marrow chimerism in germfree mice. 1. Prevention of spontaneous leukemia in AKR mice. Proc Soc Exp Biol Med 1973; 144: 659.
Tanaka T, Obata Y, Fernandes G, Onoe K, Stockert E, Good RA. Prevention of leukemia in lethally irradiated AKR mice by CBA/H marrow transplantation. Proc Am Assoc Cancer Res 1979; 20: 114.
Wustrow TPU, Good RA. Expression of antigens coded in mutine leukemia viruses on thymocytes of allogeneic donor origin in AKR mice following syngeneic or allogeneic bone marrow transplantation. Cancer Res 1985; 45: 6428.
Sykes M, Romick ML, Sachs DH. Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells. Proc Natl Acad Sci USA 1990; 87: 5633.
Ackerstein A, Kedar E, Slavin S. Use of recombinant human interleukin-2 in conjunction with syngeneic bone marrow transplantation in mice as a model for control of minimal residual disease in malignant hematologic disorders. Blood 1991; 78: 1212.
Kwak LW, Campbell MJ, Levy R. Tumor resistance induced by syngeneic bone marrow transprantation and enhanced by interleukin 2: A model for the graft versus leukemia reaction. Cancer Res 1992; 52: 4117.
Hashino S. (1994) Antileukemic effects of interleukin-2 on spontaneous development of leukemia after H-2-compatible allogeneic bone marrow transplantation in AKR/J mice. Hokkaido J Med Sci 69: 601–613
Hashino S, Imamura M, Zhu X, Imai K, Kobayashi S, Tanaka J, Fujii Y, Kasai M, Miyazaki T. (1995) Effects of interleukin 2 on leukemia development after bone marrow transplantation in AKR/J mice. Transplantation 59: 1643–1645
Heslop HE, Gottlieb DJ, Bianchi ACM, et al. In vivo induction of gamma interferon and tumor necrosis factor by interleukin-2 infusion following intensive chemotherapy or autologous marrow transplantation. Blood 1989; 74: 1374.
Tanaka J, Imamura M, Kasai M, et al. Cytokine gene expression in peripheral blood mononuclear cells during graft-verus-host disease after allogeneic bone marrow transplantation. Br J Haematol 1993; 85: 558.
Imamura M, Hashino S, Kobayashi H, et al. Serum cytokine levels in bone marrow transplantation: Synergistic interaction of interleukin-6, interferon-γ, and tumor necrosis factor-α in graft-versus-host disease. Bone Marrow Transplant 1994; 13: 745.
Takikawa O, Oku T, Yasui H, Yoshida R. Synergism between IFN-γ and IL-lα/β in growth inhibition of an allografted tumor. J Immunol 1993; 151: 2070.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Tokyo
About this paper
Cite this paper
Hashino, S., Imamura, M., Tanaka, J., Kobayashi, S., Kasai, M., Asaka, M. (1996). Antileukemic Effects of Interleukin 2 after Allogeneic Bone Marrow Transplantation in AKR/J Mice. In: Ikehara, S., Takaku, F., Good, R.A. (eds) Bone Marrow Transplantation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68320-9_35
Download citation
DOI: https://doi.org/10.1007/978-4-431-68320-9_35
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68322-3
Online ISBN: 978-4-431-68320-9
eBook Packages: Springer Book Archive