Abstract
Recently, a working group recommended that hepatitis A virus (HAV) be reclassified within a new genus (Hepatovirus) of the family Picornaviridae. Properties which distinguish the hepatoviruses from other picornaviruses include hepatotropism, a tendency to establish persistent infections in cell cultures, an exceptional stability to acid and heat, and a monotypic antigenic structure, as well as a unique pattern of processing of the capsid protein precursors and the probable lack of myristylation of VP4. The decision to place HAV within a novel genus was also influenced by the extreme genetic distance that exists between HAV and all other picornaviral genera. “Genotypes” of HAV have been defined as those strains sharing > 85% nucleotide sequence identity within a short segment of the genome located at the VP1/PX junction. Viruses recovered from humans comprise four distinct genotypes (I, II, III, and VII), while three other genotypes (IV, V, and VI) are each represented thus far by a single simian HAV strain.
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References
Lemon SM, Robertson BH (1993) Current perspectives in the virology and molecular biology of hepatitis A virus. Sem Virol 4: 285
Gust ID, Coulepis AG, Feinstone SM, Locarnini SA, Moritsugu Y, Najera R, Siegl G (1983) Taxonomic classification of hepatitis A virus. Intervirology 20: 1–7
Palmenberg AC (1989) Sequence alignments of picornaviral capsid proteins. In: Semler BL, Ehrenfeld E (eds) Molecular aspects of picornaviral infection and detection. American Society for Microbiology, Washington, D.C.
Minor PD (1991) Picornaviridae. In: Franki RIB, Fauquet CM, Knudson DL, Brown F (eds) Classification and nomenclature of viruses: The fifth report of the International Committee on Taxonomy of Viruses. Springer, Berlin Heidelberg New York, Arch Viro Suppl I I
Hogle JM, Chow M, Filman DJ (1985) Three-dimensional structure of poliovirus at 2.9A resolution. Science 229: 1358–1365
Luo M, Vriend G, Kamer G, Minor I, Arnold E, Rossmann MG, Boege U, Scraba DG, Duke GM, Palmenberg A (1987) The atomic structure of mengo virus at 3.OA resolution. Science 235: 182–191
** L-H, Lemon SM (1992) Antigenic structure of human hepatitis A virus defined by analysis of escape mutants selected against murine monoclonal antibodies. J Virol 66: 2208–2216
Brown EA, Day SP, Jansen RW, Lemon SM (1991) The 5′ nontranslated region of hepatitis A virus RNA: Secondary structure and elements required for translation in vitro. J Virol 65: 5828–5838
Cohen JI, Ticehurst JR, Purcell RH, Buckler-White A, Baroudy BM (1987) Complete nucleotide sequence of wild-type hepatitis A virus: Comparison with different strains of hepatitis A virus and other picornaviruses. J Virol 61: 50–59
Harmon SA, Updike W, Jia XY, Summers DF, Ehrenfeld E (1992) Polyprotein processing in cis and in trans by hepatitis A virus 3C protease cloned and expressed in Escherichia coli. J Virol 66: 5242–5247
Scholz E, Heinricy U, Flehming B (1989) Acid stability of hepatitis A virus. J Gen Virol 70: 2481–2485
Siegl G, Weitz M, Kronauer G (1984) Stability of hepatitis A virus. Intervirology 22: 218–226
Nainan OV, Margolis HS, Brinton MA (1992) Identification of amino acids located in antibody binding sites of human hepatitis A virus. Virology 191: 948–987
Jansen RW, Siegl G, Lemon SM (1990) Molecular epidemiology of human hepatitis A virus defined by an antigen-capture polymerase chain reaction method. Proc Natl Acad Sci USA 87: 2867–2871
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© 1994 Springer-Verlag Tokyo
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Lemon, S.M., Robertson, B.H. (1994). Taxonomic Classification of Hepatitis A Virus. In: Nishioka, K., Suzuki, H., Mishiro, S., Oda, T. (eds) Viral Hepatitis and Liver Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68255-4_13
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DOI: https://doi.org/10.1007/978-4-431-68255-4_13
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