Abstract
In two cases of unresectable HCC with multiple lesions, in which TAE was not indicated due to the vascular abnormality or allergy against iodide contrast medium, combination therapy with systemic low-dose IL-2 infusion and local low-dose tumor irradiation exhibited apparent anti-tumor effects such as the decrease of blood tumor marker level and the mass reduction judged by imaging diagnosis. Enhancement of NK and LAK cell killing, and the increased expression of IL-2R on NK cells were observed after the treatment. There were no serious side effects associated with the treatment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Satoh M, Inagawa H, Shimada Y, Soma G-I, Oshima H, Mizuno D (1987) Endogenous production of tumor necrsis factor in normal mice and human cancer patients by interferons and other cytokines combined with biological response modifiers of bacterial origin. J Biol Response Mod 6:512–524
Rosenberg SA(1988) The development of new immunotherapies for the treatment of cancer using interleukin-2. Ann.Surgery 208:121–135.
Atzpodien J, Korfer A, Franks CR, Franks CR, Poliwoda H, Kirchner H (1990) Home therapy with recombinant interleukin-2 and interferon-alpha2b in advanced human malignancies. Lancet 335:1509–1513.
Maas R, Dullens HFJ, De Jong W, Den Otter W (1989) Immunotherapy of mice with a large burden of disseminated lymphoma with low-dose interleukin-2. Cancer Res 49:7037–7040.
Talmadge JE, Phillips H, Schneider J, Tribble H, Pennington R, (1987) Systematic preclinical study on the therapeutic properties of recombinant human interleukin 2 for the treatment of metastatic disease. Cancer Res 47:5725–5730.
Mills C, North R. (1983) Expression of passively tranferred immunity against an established tumor depends on generation of cytolytic T cells in recipient -.Inhibition of suppressor T cells. J Exp Med 157:1448–1460.
Cohen J. (1991) Programmed cell death in the immune system. Advances in Immunology 50:55–85.
Cameron R, Spiess P, Rosenberg S. (1990) Synergistic antitumor activity of tumor-infiltrating lymphocytes, interleukin 2 and local tumor irradiation. J Exp Med 171:249–263.
Mukai M, Morita S, Tsunemoto H.(1992) Combination therapy of local administration of OK-432 and radiation for esophageal cancer. Int J Radiation Oncology Biol Phys 22:1047–1050.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Tokyo
About this paper
Cite this paper
Tsuchida, T. et al. (1993). Therapeutic Strategy for Advanced Hepatocellular Carcinoma Using Systemic Interleukin-2 Infusion and Local Low-Dose Irradiation. In: Takahashi, T. (eds) Recent Advances in Management of Digestive Cancers. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68252-3_195
Download citation
DOI: https://doi.org/10.1007/978-4-431-68252-3_195
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68254-7
Online ISBN: 978-4-431-68252-3
eBook Packages: Springer Book Archive