Abstract
Bisphosphonates are compound which contain a central P-C-P bond and are thus structurally related to the inorganic pyrophosphates, but are resistant to metabolic destruction (Fig.1). They bind strongly onto the hydroxyapatite crystal and reduce crystal nucleation, aggregation, growth and dissolution in vitro. Further, they decrease the mineralization of bone and dentin and inhibit bone resorption in vivo [1].
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© 1991 Springer-Verlag Tokyo
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Ohya, K., Mataki, S., Wakamatsu, H., Ogura, H. (1991). Effects of 1-Hydroxyethylidene-1, 1-Bisphosphonate (HEBP) on the Maturation Enamel in Rat Incisor. In: Suga, S., Nakahara, H. (eds) Mechanisms and Phylogeny of Mineralization in Biological Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68132-8_34
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DOI: https://doi.org/10.1007/978-4-431-68132-8_34
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