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Enhancement of Cytotoxic Effects of Chemotherapeutic Agents with Hyperthermia In Vitro

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Thermotherapy for Neoplasia, Inflammation, and Pain

Summary

Interactive effects of combined treatment with hyperthermia and chemotherapeutic agents were interpreted in the experimental aspects of medical science. A survey of the literature and our own studies indicate that cytotoxicity of alkylating agents, cisplatin, bleomycin, and mitomycin C (MMC) can be enhanced at elevated temperatures. However, the thermal enhancement of doxorubicin (Dox) is complicated or even doubtful against tumors, because Dox could potentially enhance production of heat-induced heat-shock proteins that may contribute to certain mechanisms in the development of thermotolerance. Comparative studies indicated that the thermal enhancement of MMC cytotoxicity is marked and that the development of thermotolerance was partially inhibited by MMC. An interesting observation is that the cytotoxicity of some drugs is enhanced by mild hyperthermia. These findings are significant in the use of chemotherapy together with mild hyperthermia, which can avoid potential heat-induced normal tissue damage following local or regional hyperthermia.

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Author information

Authors and Affiliations

  1. Departments of Otorhinolaryngology, Fukui Medical University, Matsuoka, Fukui, 910-1193, Japan

    Toshio Ohtsubo, Takehisa Saito & Hitoshi Saito

  2. Departments of Experimental Radiology and Health Physics, Fukui Medical University, Matsuoka, Fukui, 910-1193, Japan

    Eiichi Kano, Sachiko Hayashi, Masanori Hatashita & Hideki Matsumoto

  3. Departments of Neurosurgery, Fukui Medical University, Matsuoka, Fukui, 910-1193, Japan

    Ryuhei Kitai

Authors
  1. Toshio Ohtsubo
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  2. Eiichi Kano
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  3. Sachiko Hayashi
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  4. Masanori Hatashita
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  5. Hideki Matsumoto
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  6. Ryuhei Kitai
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  7. Takehisa Saito
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  8. Hitoshi Saito
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Editor information

Editors and Affiliations

  1. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852-8523, Nagasaki, Japan

    Mitsuo Kosaka

  2. Health Research Foundation, 606-8225, Kyoto, Japan

    Tsutomu Sugahara

  3. Clinic of Rheumatology, Physical Medicine, and Balneology, University of Giessen, Bad Nauheim, Germany

    Klaus L. Schmidt

  4. Max Planck Institute for Physiological and Clinical Research, W.G. Kerckhoff Institute, Bad Nauheim, Germany

    Eckhart Simon

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© 2001 Springer Japan

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Ohtsubo, T. et al. (2001). Enhancement of Cytotoxic Effects of Chemotherapeutic Agents with Hyperthermia In Vitro. In: Kosaka, M., Sugahara, T., Schmidt, K.L., Simon, E. (eds) Thermotherapy for Neoplasia, Inflammation, and Pain. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67035-3_51

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  • DOI: https://doi.org/10.1007/978-4-431-67035-3_51

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67037-7

  • Online ISBN: 978-4-431-67035-3

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