Summary
Muscarinic acetylcholine receptors (mAChRs) utilize the direct signaling pathway to ADP-ribosyl cyclase via G proteins within cell membranes to produce cyclic ADP-ribose (cADPR) from ß-NAD+. This signal cascade is analogous to the previously established transduction pathways from mAChRs to adenylyl cyclase and phospholipase Cß. Together with cytosolic Ca2+, cADPR functions to release Ca2+ through ryanodine receptors. This cADPR-dependent and mAChR-controlled increase in cytosolic Ca2+ concentrations may induce various cellular responses.
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Higashida, H., Yokoyama, S., Hashii, M., Taketo, M. (2000). Slow Synaptic Responses in Neuronal Tumor Cells: Dual Regulation of ADP-Ribosyl Cyclase and Inhibition of M-Current by Muscarinic Receptor Stimulation. In: Kuba, K., Higashida, H., Brown, D.A., Yoshioka, T. (eds) Slow Synaptic Responses and Modulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66973-9_4
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DOI: https://doi.org/10.1007/978-4-431-66973-9_4
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