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The Immunopathology of Behçet’s Disease

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Behçet's Disease

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Abstract

Aberrant immune functions including but not restricted to skewed T cell responses and intrinsic activation of B lymphocytes contributed to the development of Behçet’s disease (BD). Recently, we found that Th17 cells, a new helper T (Th) cell subset which produces IL17 family cytokines, increased in patients with BD. Precise analyses disclosed that Th1/Th17 cells which harbor both phenotypes of IFNgamma-producing cells and that of IL17-producing cells simultaneously increased significantly in patients with BD.

We found that macrophages/monocytes regulated Th cell differentiation through a heat-shock protein (HSP) in both systemic immune system and local inflammatory lesions in patients with BD. Here, we summarize current findings on Th cell differentiation, antigen-presenting cell (APC) activation, and their contribution to the pathogenesis of BD, especially in view of IL12/IL23 family cytokine production and pattern recognition receptor (PRR) function of macrophages/monocytes.

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Acknowledgement

Our works were supported in part by grants from Behçet’s Disease Research Committee, Research on Specific Disease of the Health Science Research Grants from the Ministry of Health, Labor and Welfare, Japan.

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  1. Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan

    Noboru Suzuki & Jun Shimizu

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  1. Noboru Suzuki
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  2. Jun Shimizu
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Correspondence to Noboru Suzuki .

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  1. Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan

    Yoshiaki Ishigatsubo

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© 2015 Springer Japan

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Suzuki, N., Shimizu, J. (2015). The Immunopathology of Behçet’s Disease. In: Ishigatsubo, Y. (eds) Behçet's Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54487-6_2

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  • DOI: https://doi.org/10.1007/978-4-431-54487-6_2

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