Abstract
In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses only one functional odorant receptor (OR) species. Furthermore, OSN axons bearing the same OR converge to a specific projection site in the olfactory bulb (OB), forming a glomerular structure. Based on these two basic principles, odor information detected in the olfactory epithelium is converted to a topographic map of activated glomeruli in the OB. During embryonic development, the olfactory map is formed by the combination of two genetically programmed processes. One is OR-dependent projection along the anterior-posterior axis, and the other is OR-independent projection along the dorsal-ventral axis. The map is further refined in an activity-dependent manner during the neonatal period. Here, we discuss a recent progress of neural map formation in the mouse olfactory system.
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Acknowledgments
This work was supported by the CREST Program of the Japan Science and Technology Agency and a Specially Promoted Research Grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
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Sakano, H. (2014). Olfactory Map Formation in the Mouse. In: Mori, K. (eds) The Olfactory System. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54376-3_3
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DOI: https://doi.org/10.1007/978-4-431-54376-3_3
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