Zusammenfassung
Posttranskriptionale Modifikationen können zur Reduktion der Expression von Genen führen (PTGS, post-transcriptional gene silencing). Sie waren lange Zeit nur in Pflanzen durchführbar und wurden als unzureichend erklärbare Phänomene bezeichnet. Zu den Methoden des PTGS zählt auch die RNA-interference (RNAi). Doppelsträngige RNA (dsRNA) wird dabei in eine Zelle eingeschleust und führt so intrazellulär zum sequenzspezifischen Abbau der komplementären mRNA.
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Bopp, T., Klein, M. (2012). RNA-interference . In: Jansohn, M., Rothhämel, S. (eds) Gentechnische Methoden. Spektrum Akademischer Verlag, Heidelberg. https://doi.org/10.1007/978-3-8274-2430-3_8
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