Zusammenfassung
Die ätiologisch heterogene Gruppe der neuromuskulären Erkrankungen manifestiert sich typischerweise mit einer Abnahme der Kraft, Ausdauer und Muskelmasse sowie einem Umbau der Muskulatur. Je nach konkret vorliegender Erkrankung muss auch eine Beteiligung der Herz- und Atemmuskulatur berücksichtigt werden. Häufig sind Schmerzen mit der Erkrankung selbst oder den Erkrankungsfolgen wie Skoliosen und Gelenkdeformitäten assoziiert. Die Gehfähigkeit und andere für die Alltagsbewältigung relevante Funktionen sind häufig beeinträchtigt. Hieraus resultieren erhebliche Konsequenzen für die Partizipation, die Integration in Familie, Freundeskreis und Beruf und damit die Lebensqualität. Die Erkrankungen verändern das körperliche und soziale Selbst, sie haben damit Auswirkungen auf Identität, Selbstbewusstsein und Handeln. Auch das Co**, der Umgang mit der Erkrankung, beeinflusst die Lebensqualität. Das Kapitel stellt die aktuellen rehabilitativen Therapieansätze dar.
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Literatur
Abresch RT, Han JJ, Carter GT (1993) Rehabilitation management of neuromuscular disease: the role of exercise training. Arch Phys Med Rehabil 11:7–21. https://doi.org/10.1097/CND.0b013e3181a8d36b
Ahmed ST, Craven L, Russell OM, Turnbull DM, Vincent AE (2018) Diagnosis and treatment of mitochondrial myopathies. Neurotherapeutics 15:943–953. https://doi.org/10.1007/s13311-018-00674-4
Alexanderson H (2018) Exercise in myositis. Curr Treatm Opt Rheumatol. 4:289–298. https://doi.org/10.1007/s40674-018-0113-3
Alexanderson H, Dastmalchi M, Esbjörnsson-Liljedahl M, Opava CH, Lundberg IE (2007) Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis. Arthritis Rheum 57:768–777. https://doi.org/10.1002/mus.25493
Alexanderson H, Regardt M, Ottosson C, Alemo Munters L, Dastmalchi M, Dani L, Lundberg IE (2018) Muscle strength and muscle endurance during the first year of treatment of polymyositis and dermatomyositis: a prospective study. J Rheumatol 45:538–546. https://doi.org/10.3899/jrheum.161183
Andersen G, Prahm KP, Dahlqvist JR, Citirak G, Vissing J (2015) Aerobic training and postexercise protein in facioscapulohumeral muscular dystrophy: RCT study. Neurology 85:396–403. https://doi.org/10.1212/WNL.0000000000001808
Andersen G, Heje K, Buch AE, Vissing J (2017) High-intensity interval training in facioscapulohumeral muscular dystrophy type 1: a randomized clinical trial. J Neurol 264:1099–1106. https://doi.org/10.1007/s00415-017-8497-9
Andreasson K, Sandlund H, Alexanderson H (2020) Patients with inflammatory myopathies who do not reach health enhancing levels of physical activity report higher levels of anxiety and depression – a cross-sectional study of self-reported data. Ann Rheum Dis 79:1269. https://ard.bmj.com/content/79/Suppl_1/1269.2.info
Anziska Y, Sternberg A (2013) Exercise in neuromuscular disease. Muscle Nerve 48:3–20. https://doi.org/10.1002/mus.23771
Arnardottir S, Alexanderson H, Lundberg IE, Borg K (2003) Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction. J Rehabil Med 35:31–35. https://doi.org/10.1080/16501970306110
Bankolé LC, Millet GY, Temesi J, Bachasson D, Ravelojaona M, Wuyam B, Verges S, Ponsot E, Antoine JC, Kadi F, Féasson L (2016) Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy: a randomized controlled trial. Medicine (Baltimore) 95:e4497. https://doi.org/10.1097/MD.0000000000004497
Baranello G, Darras BT, Day JW, Deconinck N, Klein A, Masson R, Mercuri E, Rose K, El-Khairi M, Gerber M, Gorni K, Khwaja O, Kletzl H, Scalco RS, Seabrook T, Fontoura P, Servais L, FIREFISH Working Group (2021) Risdiplam in type 1 spinal muscular atrophy. N Engl J Med 384:915–923. https://doi.org/10.1056/NEJMoa2009965
Bartels B, Montes J, van der Pol WL, de Groot JF (2019) Physical exercise training for type 3 spinal muscular atrophy. Cochrane Database Syst Rev 3:CD012120. https://doi.org/10.1002/14651858.CD012120.pub2
Bello-Haas VD, Florence JM (2013) Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease. Cochrane Database Syst Rev 31:CD005229. https://doi.org/10.1002/14651858.CD005229.pub3
Bello-Haas VD, Florence JM, Kloos AD, Scheirbecker J, Lopate G, Hayes SM, Pioro EP, Mitsumoto H (2007) A randomized controlled trial of resistance exercise in individuals with ALS. Neurology 68:2003–2007. https://doi.org/10.1212/01.wnl.0000264418.92308.a4
Bird TD (1998, updated 2022) Charcot-Marie-Tooth hereditary neuropathy overview. In: Adam MP, Everman DB, Mirzaa G, Pagon RA, Wallace E (Hrsg) GeneReviews® [Internet]. University of Washington, Seattle. https://www.ncbi.nlm.nih.gov/books/NBK1358/
Blaauw B, Agatea L, Toniolo L, Canato M, Quarta M, Dyar KA, Danieli-Betto D, Betto R, Schiaffino S, Reggiani C (2010) Eccentric contractions lead to myofibrillar dysfunction in muscular dystrophy. J Appl Physiol 2010:105–111. https://doi.org/10.1152/japplphysiol.00803.2009
Blaszczyk E, Lim C, Kellman P, Schmacht L, Gröschel J, Spuler S, Schulz-Menger J (2021) Progressive myocardial injury in myotonic dystrophy type II and facioscapulohumeral muscular dystrophy 1: a cardiovascular magnetic resonance follow-up study. J Cardiovasc Magn Reson 23:130. https://doi.org/10.1186/s12968-021-00812-6
Boentert M, Young P (2014) Pompe-Krankheit (Glykogenose Typ II). In: vom Dahl S, Lammert F, Ullrich K, Wendel U (Hrsg) Angeborene Stoffwechselkrankheiten bei Erwachsenen. Springer, Berlin/Heidelberg. https://doi.org/10.1007/978-3-642-45188-1_47
Boentert M, Prigent H, Várdi K, Jones HN, Mellies U, Simonds AK, Wenninger S, Barrot Cortés E, Confalonieri M (2016) Practical recommendations for diagnosis and management of respiratory muscle weakness in late-onset pompe disease. Int J Mol Sci 17:1735. https://doi.org/10.3390/ijms17101735
Boentert M, Wenninger S, Sansone VA (2017) Respiratory involvement in neuromuscular disorders. Curr Opin Neurol 30:529–537. https://doi.org/10.1097/WCO.0000000000000470
Bonne G, Rivier F, Hamroun D (2022) Genetable of neuromuscular disorders. http://www.musclegenetable.fr/index.html. Zugegriffen am 25.09.2022
Brun BN, Mockler SR, Laubscher KM, Stephan CM, Collison JA, Zimmerman MB, Mathews KD (2017) Childhood activity on progression in limb girdle muscular dystrophy 2I. J Child Neurol 32:204–209. https://doi.org/10.1177/0883073816677680
Call JA, Eckhoff MD, Baltgalvis KA, Warren GL, Lowe DA (2011) Adaptive strength gains in dystrophic muscle exposed to repeated bouts of eccentric contraction. J Appl Physiol 111:1768–1777. https://doi.org/10.1152/japplphysiol.00942.2011
Corrado B, Giardulli B, Costa M (2020) Evidence-based practice in rehabilitation of myasthenia gravis. A systematic review of the literature. J Funct Morphol Kinesiol 5:71. https://doi.org/10.3390/jfmk5040071
Deenen JC, Horlings CG, Verschuuren JJ, Verbeek AL, van Engelen BG (2015) The epidemiology of neuromuscular disorders: a comprehensive overview of the literature. J Neuromuscul Dis. 2:73–85. https://doi.org/10.3233/JND-140045
Deschauer M, Sproß J, Gläser D, Grimm A, Schara-Schmidt U, Scheidegger O, Schoser B, Wanschitz J, Weis J, Zierz S (2021) Diagnostik von Myopathien, S1-Leitlinie. In: Deutsche Gesellschaft für Neurologie (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. www.dgn.org/leitlinien. Zugegriffen am 18.04.2022
Dresser L, Wlodarski R, Rezania K, Soliven B (2021) Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations. J Clin Med 10:2235. https://doi.org/10.3390/jcm10112235
Drory VE, Goltsman E, Reznik JG, Mosek A, Korczyn AD (2001) The value of muscle exercise in patients with amyotrophic lateral sclerosis. Neurol Sci 191:133–137. https://doi.org/10.1016/s0022-510x(01)00610-4
Emery AE (1991) Population frequencies of inherited neuromuscular diseases – a world survey. Neuromuscul Disord 1:19–29. https://doi.org/10.1016/0960-8966(91)90039
Esser P, Metelmann M, Hartung T, Claßen J, Mehnert A, Koranyi S (2019) Psychosoziale Versorgung bei Patienten mit Amyotropher Lateralsklerose: Ein narrativer Review. Psychother Psych Med 69:372–381. https://doi.org/10.1055/a-0806-7862
Farrugia ME, Di Marco M, Kersel D, Carmichael C (2018) A physical and psychological approach to managing fatigue in myasthenia gravis: a pilot study. J Neuromuscul Dis. 5:373–385. https://doi.org/10.3233/JND-170299
Feingold B, Mahle WT, Auerbach S, Clemens P, Domenighetti AA, Jefferies JL, Judge DP, Lal AK, Markham LW, Parks WJ, Tsuda T, Wang PJ, Yoo SJ, American Heart Association Pediatric Heart Failure Committee of the Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular Radiology and Intervention; Council on Functional Genomics and Translational Biology; and Stroke Council (2017) Management of cardiac involvement associated with neuromuscular diseases: a scientific statement from the American Heart Association. Circulation 136:e200–e231. https://doi.org/10.1161/CIR.0000000000000526
Finkel RS, Mercuri E, Darras BT, Connolly AM, Kuntz NL, Kirschner J, Chiriboga CA, Saito K, Servais L, Tizzano E, Topaloglu H, Tulinius M, Montes J, Glanzman AM, Bishop K, Zhong ZJ, Gheuens S, Bennett CF, Schneider E, Farwell W, De Vivo DC, ENDEAR Study Group (2017) Nusinersen versus Sham control in infantile-onset spinal muscular atrophy. N Engl J Med 377:1723–1732. https://doi.org/10.1056/NEJMoa1702752
Finkel RS, Mercuri E, Meyer OH, Simonds AK, Schroth MK, Graham RJ, Kirschner J, Iannaccone ST, Crawford TO, Woods S, Muntoni F, Wirth B, Montes J, Main M, Mazzone ES, Vitale M, Snyder B, Quijano-Roy S, Bertini E, Davis RH, Qian Y, Sejersen T, SMA Care group (2018) Diagnosis and management of spinal muscular atrophy: part 2: pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics. Neuromuscul Disord 28:197–207. https://doi.org/10.1016/j.nmd.2017.11.004
Finsterer J, Stöllberger C (2008) Primary myopathies and the heart. Scand Cardiovasc 42:9–24. https://doi.org/10.1080/14017430701854953
Forst J, Forst R (1999) Lower limb surgery in Duchenne muscular dystrophy. Neuromuscul Disord. 9:176–181. https://doi.org/10.1016/s0960-8966(98)00113-8
Fregonezi GA, Resqueti VR, Güell R, Pradas J, Casan P (2005) Effects of 8-week, interval-based inspiratory muscle training and breathing retraining in patients with generalized myasthenia gravis. Chest 128:1524–1530. https://doi.org/10.1378/chest.128.3.1524
Freitag S, Hallebach S, Baumann I, Kalischewski P, Rassler B (2018) Effects of long-term respiratory muscle endurance training on respiratory and functional outcomes in patients with Myasthenia gravis. Respir Med 144:7–15. https://doi.org/10.1016/j.rmed.2018.09.001
Gilhus NE, Tzartos S, Evoli A, Palace J, Burns TM, Verschuuren JJGM (2019) Myasthenia gravis. Nat Rev Dis Primers 5:30. https://doi.org/10.1038/s41572-019-0079-y
Goebel A, Lecky B, Smith LJ, Lunn MP (2012) Pain intensity and distribution in chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 46:294–295. https://doi.org/10.1002/mus.23355
Green JR, Allison KM, Cordella C, Richburg BD, Pattee GL, Berry JD, Macklin EA, Pioro EP, Smith RA (2018) Additional evidence for a therapeutic effect of dextromethorphan/quinidine on bulbar motor function in patients with amyotrophic lateral sclerosis: a quantitative speech analysis. Br J Clin Pharmacol 84:2849–2856. https://doi.org/10.1111/bcp.13745
Harvey LA, Katalinic OM, Herbert RD, Moseley AM, Lannin NA, Schurr K (2017) Stretch for the treatment and prevention of contractures. Cochrane Database Syst Rev 1:CD007455. https://doi.org/10.1002/14651858.CD007455.pub3
Hell AK, Braunschweig L, Tsaknakis K, von Deimling U, Lüders KA, Hecker M, Lorenz HM (2020) Children with spinal muscular atrophy with prior growth-friendly spinal implants have better results after definite spinal fusion in comparison to untreated patients. Neurosurgery. 87:910–917. https://doi.org/10.1093/neuros/nyaa053
Hillyar C, Nibber A (2020) Psychiatric sequelae of Guillain-Barré syndrome: towards a multidisciplinary team approach. Cureus 12:e7051. https://doi.org/10.7759/cureus.7051
Iolascon G, Paoletta M, Liguori S, Curci C, Moretti A (2019) Neuromuscular Diseases and Bone. Front. Endocrinol 10:794. https://doi.org/10.3389/fendo.2019.00794
Jackson CE, McVey AL, Rudnicki S, Dimachkie MM, Barohn RJ (2015) Symptom management and end-of-life care in amyotrophic lateral sclerosis. Neurol Clin 33:889–908. https://doi.org/10.1016/j.ncl.2015.07.010
Jansen B, Voet N, Geurts A, van Engelen B, Heerschap A (2016) Quantitative MRI reveals decelerated infiltration in muscles of active FSHD patients. Neurology 86:1700–1707. https://doi.org/10.1212/01.wnl.0000504577.93225.eb
Jensen BR, Berthelsen MP, Husu E, Christensen SB, Prahm KP, Vissing J (2016) Body weight-supported training in Becker and limb girdle 2I muscular dystrophy. Muscle Nerve 54:239–243. https://doi.org/10.1002/mus.25039
Johnson LG, Collier KE, Edwards DJ, Philippe DL, Eastwood PR, Walters SE, Thickbroom GW, Mastaglia FL (2009) Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis. J Clin Neuromuscul Dis 10:178–184. https://doi.org/10.1097/CND.0b013e3181a23c86
Kapandji A (1987) Proposition pour une cotation clinique de la flexion-extension des doigts longs [Proposal for a clinical score for flexion-extension of the long fingers]. Ann Chir Main 6:288–294. https://doi.org/10.1016/s0753-9053(87)80037-6
Kilmer DD (1998) The role of exercise in neuromuscular disease. Phys Med Rehabil Clin N Am. 9:115–125. https://doi.org/10.1016/S1047-9651(18)30282-1
Kilmer DD, McCrory MA, Wright NC, Aitkens SG, Bernauer EM (1994) The effect of a high resistance exercise program in slowly progressive neuromuscular disease. Arch Phys Med Rehabil 75:560–563. https://doi.org/10.1016/S0003-9993(21)01620-8
Knak KL, Andersen LK, Vissing J (2017) Aerobic anti-gravity exercise in patients with Charcot-Marie-Tooth disease types 1A and X: a pilot study. Brain Behav 7:e00794. https://doi.org/10.1002/brb3.794
Kornblum C, Eisenhardt CP, Horvath R, Jackson S, Kunz WS, Mihailova V, Schäfer J, Sperl W, Wilichowski E, Zimprich F (2021) Mitochondriale Erkrankungen, S1-Leitlinie. In: Deutsche Gesellschaft für Neurologie (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. www.dgn.org/leitlinien. Zugegriffen am 18.04.2022
Laier-Groeneveld G, Criée CP (2021) Pathophysiologie, Diagnostik und Therapie der Atempumpe. Pneumologe 18:3–12. https://doi.org/10.1007/s10405-020-00357-y
Laurá M, Singh D, Ramdharry G, Morrow J, Skorupinska M, Pareyson D, Burns J, Lewis RA, Scherer SS, Herrmann DN, Cullen N, Bradish C, Gaiani L, Martinelli N, Gibbons P, Pfeffer G, Phisitkul P, Wapner K, Sanders J, Flemister S, Shy ME, Reilly MM (2018) Inherited neuropathies consortium. Prevalence and orthopedic management of foot and ankle deformities in Charcot-Marie-Tooth disease. Muscle Nerve 57:255–259. https://doi.org/10.1002/mus.25724
Law C, Flaherty CV, Bandyopadhyay S (2020) A review of psychiatric comorbidity in myasthenia gravis. Cureus. 12:e9184. https://doi.org/10.7759/cureus.9184
Lehnerer S, Jacobi J, Schilling R, Grittner U, Marbin D, Gerischer L, Stascheit F, Krause M, Hoffmann S, Meisel A (2021) Burden of disease in myasthenia gravis: taking the patient‘s perspective. J Neurol 269:3050–3063. https://doi.org/10.1007/s00415-021-10891-1
Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, van Doorn PA, Dourado ME, Hughes RAC, Islam B, Kusunoki S, Pardo CA, Reisin R, Sejvar JJ, Shahrizaila N, Soares C, Umapathi T, Wang Y, Yiu EM, Willison HJ, Jacobs BC (2019) Diagnosis and management of Guillain-Barré syndrome in ten steps. Nat Rev Neurol. 15:671–683. https://doi.org/10.1038/s41582-019-0250-9
Li Hi Shing S, Chipika RH, Finegan E, Murray D, Hardiman O, Bede P (2019) Post-polio syndrome: more than just a lower motor neuron disease. Front Neurol 10:773. https://doi.org/10.3389/fneur.2019.00773
Lilleker JB, Gordon P, Lamb JA, Lempp H, Cooper RG, Roberts ME, Jordan P, Chinoy H, UK Myositis Network (UKMYONET), Myositis UK (2017) Patient-centred standards of care for adults with myositis. BMC Rheumatol. 28:4. https://doi.org/10.1186/s41927-017-0002-7
Ludolph A., Petri S., Grosskreutz J, Grehl T, Hecht M, Hermann A, Jesse S, Lingor P, Maier A, Löscher W, Schoser B, Weber M (2021) Motoneuronerkrankungen, S1-Leitlinie. In: Deutsche Gesellschaft für Neurologie (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. www.dgn.org/leitlinien. Zugegriffen am 16.01.2022
Markert CD, Case LE, Carter GT, Furlong PA, Grange RW (2012) Exercise and Duchenne muscular dystrophy: where we have been and where we need to go. Muscle Nerve. 45:746–751. https://doi.org/10.1002/mus.23244
Markvardsen LH, Overgaard K, Heje K, Sindrup SH, Christiansen I, Vissing J, Andersen H (2018) Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 57:70–76. https://doi.org/10.1002/mus.25652
Masrori P, Van Damme P (2020) Amyotrophic lateral sclerosis: a clinical review. Eur J Neurol 27:1918–1929. https://doi.org/10.1111/ene.14393
McDonald CM (1998) Limb contractures in progressive neuromuscular disease and the role of stretching, orthotics, and surgery. Phys Med Rehabil Clin N Am. 9:187–211. https://doi.org/10.1016/S1047-9651(18)30286-9
Mendell JR, Al-Zaidy S, Shell R, Arnold WD, Rodino-Klapac LR, Prior TW, Lowes L, Alfano L, Berry K, Church K, Kissel JT, Nagendran S, L‘Italien J, Sproule DM, Wells C, Cardenas JA, Heitzer MD, Kaspar A, Corcoran S, Braun L, Likhite S, Miranda C, Meyer K, Foust KD, Burghes AHM, Kaspar BK (2017) Single-dose gene-replacement therapy for spinal muscular atrophy. N Engl J Med 377:1713–1722. https://doi.org/10.1056/NEJMoa1706198
Meng L, Li X, Li C, Tsang RCC, Chen Y, Ge Y, Gao Q (2020) Effects of exercise in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis. Am J Phys Med Rehabil. 99:801–810. https://doi.org/10.1097/PHM.0000000000001419
Mercuri E, Darras BT, Chiriboga CA, Day JW, Campbell C, Connolly AM, Iannaccone ST, Kirschner J, Kuntz NL, Saito K, Shieh PB, Tulinius M, Mazzone ES, Montes J, Bishop KM, Yang Q, Foster R, Gheuens S, Bennett CF, Farwell W, Schneider E, De Vivo DC, Finkel RS, CHERISH Study Group (2018a) Nusinersen versus Sham control in later-onset spinal muscular atrophy. N Engl J Med 378:625–635. https://doi.org/10.1056/NEJMoa1710504
Mercuri E, Finkel RS, Muntoni F, Wirth B, Montes J, Main M, Mazzone ES, Vitale M, Snyder B, Quijano-Roy S, Bertini E, Davis RH, Meyer OH, Simonds AK, Schroth MK, Graham RJ, Kirschner J, Iannaccone ST, Crawford TO, Woods S, Qian Y, Sejersen T, SMA Care Group (2018b) Diagnosis and management of spinal muscular atrophy: part 1: recommendations for diagnosis, rehabilitation, orthopedic and nutritional care. Neuromuscul Disord. 28:103–115. https://doi.org/10.1016/j.nmd.2017.11.005
Merkies IS, Kieseier BC (2016) Fatigue, pain, anxiety and depression in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. Eur Neurol. 75:199–206. https://doi.org/10.1159/000445347
Meyer S, Zechel S, Schmidt J, Schröter C, Zschüntzsch J (2020) Adulte nicht-infektiöse Myositiden – Übersicht und Therapie. Neurol Rehabil. 26:32–45. https://doi.org/10.14624/NR2001004
Montes J, Garber CE, Kramer SS, Montgomery MJ, Dunaway S, Kamil-Rosenberg S (2015) Single-blind, randomized, controlled clinical trial of exercise in ambulatory spinal muscular atrophy: why are the results negative? Neuromuscul Dis 2:463–470. https://doi.org/10.3233/JND-150101
Moore U, Jacobs M, Fernandez-Torron R, Llauger Rossello J, Smith FE, James M, Mayhew A, Rufibach L, Carlier PG, Blamire AM, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Pestronk A, Walter MC, Paradas C, Stojkovic T, Mori-Yoshimura M, Bravver E, Pegoraro E, Mendell JR, Bushby K, Straub V, Diaz-Manera J (2020) Intensive teenage activity is associated with greater muscle hyperintensity on T1W magnetic resonance imaging in adults with dysferlinopathy. Front Neurol. 11:613446. https://doi.org/10.3389/fneur.2020.613446
Moore UR, Jacobs M, Fernandez-Torron R, Jang J, James MK, Mayhew A, Rufibach L, Mittal P, Eagle M, Cnaan A, Carlier PG, Blamire A, Hilsden H, Lochmüller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Diaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V (2018) Teenage exercise is associated with earlier symptom onset in dysferlinopathy: a retrospective cohort study. J Neurol Neurosurg Psychiatry 11:1224–1226. https://doi.org/10.1136/jnnp-2017-317329
Mori L, Signori A, Prada V, Pareyson D, Piscosquito G, Padua L, Pazzaglia C, Fabrizi GM, Picelli A, Schenone A (2020) TreSPE study group. Treadmill training in patients affected by Charcot-Marie-Tooth neuropathy: results of a multicenter, prospective, randomized, single-blind, controlled study. Eur J Neurol. 27:280–287. https://doi.org/10.1111/ene.14074
Mullender M, Blom N, De Kleuver M, Fock J, Hitters W, Horemans A, Kalkman C, Pruijs J, Timmer R, Titarsolej P, Van Haasteren N, Jager MV, Van Vught A, Van Royen BA (2008) Dutch guideline for the treatment of scoliosis in neuromuscular disorders. Scoliosis 3:14. https://doi.org/10.1186/1748-7161-3-14
Munters LA, Dastmalchi M, Katz A, Esbjörnsson M, Loell I, Hanna B, Lidén M, Westerblad H, Lundberg IE, Alexanderson H (2013) Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis. Arthritis Res Ther 15:R83. https://doi.org/10.1186/ar4263
Munters LA, Loell I, Ossipova E, Raouf J, Dastmalchi M, Lindroos E, Chen YW, Esbjörnsson M, Korotkova M, Alexanderson H, Nagaraju K, Crofford LJ, Jakobsson PJ, Lundberg IE (2016) Endurance exercise improves molecular pathways of aerobic metabolism in patients with myositis. Arthritis Rheumatol. 68:1738–1750. https://doi.org/10.1002/art.39624
Muntoni F, Bushby K, Manzur AY (2006) Muscular dystrophy campaign funded workshop on management of scoliosis in Duchenne muscular dystrophy 24 January 2005, London, UK. Neuromuscul Disord. 16:210–219. https://doi.org/10.1016/j.nmd.2006.01.004
O‘Connor L, Westerberg E, Punga AR (2019) Pattern of habitual physical exercise in myasthenia gravis patients. J Neuromuscul Dis 6:85–91. https://doi.org/10.3233/JND-180355
O‘Connor L, Westerberg E, Punga AR (2020) Myasthenia gravis and physical exercise: a novel paradigm. Front Neurol 29:675. https://doi.org/10.3389/fneur.2020.00675
Okkersen K, Jimenez-Moreno C, Wenninger S, Daidj F, Glennon J, Cumming S, Littleford R, Monckton DG, Lochmüller H, Catt M, Faber CG, Hapca A, Donnan PT, Gorman G, Bassez G, Schoser B, Knoop H, Treweek S, van Engelen BGM (2018) OPTIMISTIC consortium. Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial. Lancet Neurol 17:671–680. https://doi.org/10.1016/S1474-4422(18)30203-5
Peseschkian T, Cordts I, Günther R, Stolte B, Zeller D, Schröter C, Weyen U, Regensburger M, Wolf J, Schneider I, Hermann A, Metelmann M, Kohl Z, Linker RA, Koch JC, Büchner B, Weiland U, Schönfelder E, Heinrich F, Osmanovic A, Klopstock T, Dorst J, Ludolph AC, Boentert M, Hagenacker T, Deschauer M, Lingor P, Petri S, Schreiber-Katz O (2021) A nation-wide, multi-center study on the quality of life of ALS patients in Germany. Brain Sci. 11:372. https://doi.org/10.3390/brainsci11030372
Petrof BJ (1998) The molecular basis of activity-induced muscle injury in Duchenne muscular dystrophy. Mol Cell Biochem 179:111–123. https://doi.org/10.1023/a:1006812004945
Pietrusz A, Scalco RS, Quinlivan R (2018) Resistance exercise training in McArdle disease: myth or reality? Case Rep Neurol Med 9658251. https://doi.org/10.1155/2018/9658251
Prada V, Mori L, Accogli S, Rivarola M, Schizzi S, Hamedani M, Schenone A (2018a) Testing overwork weakness in Charcot-Marie-Tooth disease: is it true or false? J Peripher Nerv Syst 23:124–128. https://doi.org/10.1111/jns.12270
Prada V, Schizzi S, Poggi I, Mori L, Gemelli C, Hamedani M, Accogli S, Maggi G, Grandis M, Mancardi GL, Schenone A (2018b) Hand rehabilitation treatment for Charcot-Marie-Tooth disease: an open label pilot study. J Neurol Neurophysiol 30:465. https://doi.org/10.4172/2155-9562.1000465
Preisler N, Orngreen MC (2018) Exercise in muscle disorders: what is our current state? Curr Opin Neurol. 31:610–617. https://doi.org/10.1097/WCO.0000000000000597
Rahbek MA, Mikkelsen EE, Overgaard K, Vinge L, Andersen H, Dalgas U (2017) Exercise in myasthenia gravis: a feasibility study of aerobic and resistance training. Muscle Nerve 4:700–709. https://doi.org/10.1002/mus.25552
Rath A, Yamazaki M (2022) Prävalenz seltener Krankheiten: Bibliographische Angaben. Orphanet Berichtsreihe, Seltene Krankheiten Datenerhebung, Januar 2022, Nummer 1: Alphabetische Liste der Krankheiten. https://www.orpha.net/orphacom/cahiers/docs/DE/Pravalenzen_seltener_Krankheiten_Alphabetische_Liste.pdf. Zugegriffen am 25.09.2022
Refshauge KM, Raymond J, Nicholson G, van den Dolder PA (2006) Night splinting does not increase ankle range of motion in people with Charcot-Marie-Tooth disease: a randomised, cross-over trial. Aust J Physiother 52:193–199. https://doi.org/10.1016/s0004-9514(06)70028-9
Regardt M, Basharat P, Christopher-Stine L, Sarver C, Bjorn A, Lundberg IE (2015) Patients’ experience of myositis and further validation of a myositis-specific patient reported outcome measure – establishing core domains and expanding patient input on clinical assessment in myositis. Report from OMERACT 12. J Rheumatol 42:2492–2495. https://doi.org/10.3899/jrheum.141243
Reilly MM, Pareyson D, Burns J, Laurá M, Shy ME, Singh D (2017) ENMC CMT Foot Surgery Study Group. 221st ENMC international workshop: foot surgery in Charcot-Marie-Tooth disease. 10-12 June 2016, Naarden, The Netherlands. Neuromuscul Disord. 27:1138–1142. https://doi.org/10.1016/j.nmd.2017.09.005
Rose KJ, Raymond J, Refshauge K, North KN, Burns J (2010) Serial night casting increases ankle dorsiflexion range in children and young adults with Charcot-Marie-Tooth disease: a randomised trial. J Physiother 56:113–119. https://doi.org/10.1016/s1836-9553(10)70041-2
Rosenbohm A, Peter R, Dorst J, Kassubek J, Rothenbacher D, Nagel G, Ludolph AC, on behalf of the ALS Registry Swabia Study Group (2021) Life course of physical activity and risk and prognosis of amyotrophic lateral sclerosis in a German ALS registry. Neurology 97:e1955–e1963. https://doi.org/10.1212/WNL.0000000000012829
Santalla A, Munguía-Izquierdo D, Brea-Alejo L, Pagola-Aldazábal I, Díez-Bermejo J, Fleck SJ, Ara I, Lucia A (2014) Feasibility of resistance training in adult McArdle patients: clinical outcomes and muscle strength and mass benefits. Front Aging Neurosci 11:334. https://doi.org/10.3389/fnagi.2014.00334
Schischlevskij P, Cordts I, Günther R, Stolte B, Zeller D, Schröter C, Weyen U, Regensburger M, Wolf J, Schneider I, Hermann A, Metelmann M, Kohl Z, Linker RA, Koch JC, Stendel C, Müschen LH, Osmanovic A, Binz C, Klopstock T, Dorst J, Ludolph AC, Boentert M, Hagenacker T, Deschauer M, Lingor P, Petri S, Schreiber-Katz O (2021) Informal caregiving in Amyotrophic Lateral Sclerosis (ALS): a high caregiver burden and drastic consequences on caregivers‘ lives. Brain Sci. 11:748. https://doi.org/10.3390/brainsci11060748
Schmidt J (2018) Current classification and management of inflammatory myopathies. J Neuromuscul Dis. 5:109–129. https://doi.org/10.3233/JND-180308
Schneider-Gold C, Lehmann F (2017) S1-Leitlinie Myotone Dystrophien, nicht dystrophe Myotonien und periodische Paralysen. In: Deutsche Gesellschaft für Neurologie (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. www.dgn.org/leitlinien. Zugegriffen am 18.04.2022
Schömig F, Fussi J, Pumberger M, Putzier M (2021) Surgical strategies in the treatment of neuromuscular scoliosis. Der Orthopäde. 50:633–637. https://doi.org/10.1007/s00132-021-04128-2
Schröter C (2014) Glykogenose Typ V (McArdle-Krankheit). In: vom Dahl S, Lammert F, Ullrich K, Wendel U (Hrsg) Angeborene Stoffwechselkrankheiten bei Erwachsenen. Springer, Berlin/Heidelberg. https://doi.org/10.1007/978-3-642-45188-1_25
Sczesny-Kaiser M, Kowalewski R, Schildhauer TA, Aach M, Jansen O, Grasmücke D, Güttsches AK, Vorgerd M, Tegenthoff M (2017) Treadmill training with HAL exoskeleton – a novel approach for symptomatic therapy in patients with limb-girdle muscular dystrophy. Front Neurosci 8:449. https://doi.org/10.3389/fnins.2017.00449
Silvestri NJ, Ismail H, Zimetbaum P, Raynor EM (2018) Cardiac involvement in the muscular dystrophies. Muscle Nerve. 57:707–715. https://doi.org/10.1002/mus.26014
Sollerman C, Ejeskär A (1995) Sollerman hand function test. A standardised method and its use in tetraplegic patients. Scand J Plast Reconstr Surg Hand Surg 29:167–176. https://doi.org/10.3109/02844319509034334
Sommer C, Gold R, Heuss D, Kiefer R, Koeppen S, Meyer zu Hörste G, Schlotter-Weigel B, Stoll G, Tackenberg B, Faust-Becker D, Derfuss T, Zimprich F (2018) Therapie akuter und chronischer immunvermittelter Neuropathien und Neuritiden, S2e-Leitlinie. In: Deutsche Gesellschaft für Neurologie (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. www.dgn.org/leitlinie. Zugegriffen am 27.06.2022
Spector SA, Lemmer JT, Koffman BM, Fleisher TA, Feuerstein IM, Hurley BF, Dalakas MC (1997) Safety and efficacy of strength training in patients with sporadic inclusion body myositis. Muscle Nerve. 20:1242–1248. https://doi.org/10.1002/(SICI)1097-4598(199710)20:10<1242::AID-MUS6>3.0.CO;2-C
Straub V, Murphy A, Udd B, LGMD workshop study group (2018) 229th ENMC international workshop: limb girdle muscular dystrophies – nomenclature and reformed classification Naarden, the Netherlands, 17–19 March 2017. Neuromuscul Disord. 28:702–710. https://doi.org/10.1016/j.nmd.2018.05.007
Sveen ML, Jeppesen TD, Hauerslev S, Krag TO, Vissing J (2007) Endurance training: an effective and safe treatment for patients with LGMD2I. Neurology 68:59–61. https://doi.org/10.1212/01.wnl.0000250358.32199.24
Sveen ML, Andersen SP, Ingelsrud LH, Blichter S, Olsen NE, Jønck S, Krag TO, Vissing J (2013) Resistance training in patients with limb-girdle and becker muscular dystrophies. Muscle Nerve 47:163–169. https://doi.org/10.1002/mus.23491
Tsaknakis K, Braunschweig L, Lorenz HM, Hell AK (2020) Anspruch und Wirklichkeit bei der Korsettbehandlung. Orthopäde 49:59–65. https://doi.org/10.1007/s00132-019-03709-6
Van der Kooi EL, Vogels OJ, van Asseldonk RJ, Lindeman E, Hendriks JC, Wohlgemuth M, van der Maarel SM, Padberg GW (2004) Strength training and albuterol in facioscapulohumeral muscular dystrophy. Neurology 63:702–708. https://doi.org/10.1212/01.wnl.0000134660.30793.1f
Vignos PJ, Wagner MB, Karlinchak B, Katirji B (1996) Evaluation of a program for long-term treatment of Duchenne muscular dystrophy. Experience at the University Hospitals of Cleveland. J Bone Joint Surg Am 78:1844–1852. https://doi.org/10.2106/00004623-199612000-00007
Voet N, Bleijenberg G, Hendriks J, de Groot I, Padberg G, van Engelen B, Geurts A (2014) Both aerobic exercise and cognitive-behavioral therapy reduce chronic fatigue in FSHD: an RCT. Neurology 83:1914–1922. https://doi.org/10.1212/WNL.0000000000001008
Voet NB, van der Kooi EL, Riphagen II, Lindeman E, van Engelen BG, Geurts AC (2013) Strength training and aerobic exercise training for muscle disease. Cochrane Database Syst Rev 7:CD003907. https://doi.org/10.1002/14651858.CD003907.pub4
Voet NBM (2019) Exercise in neuromuscular disorders: a promising intervention. Acta Myol. 38:207–214. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955632/
Wallace A, Pietrusz A, Dewar E, Dudziec M, Jones K, Hennis P, Sterr A, Baio G, Machado PM, Laurá M, Skorupinska I, Skorupinska M, Butcher K, Trenell M, Reilly MM, Hanna MG, Ramdharry GM (2019) Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity. Neurology 92:e1773–e1785. https://doi.org/10.1212/WNL.0000000000007265
Wenninger S (2021) Definition, Pathogenese, Diagnostik und Therapie der Hypoventilation bei neuromuskulären Erkrankungen. Habilitationsschrift, LMU München: Medizinische Fakultät. https://doi.org/10.5282/edoc.27437
Westerberg E, Molin CJ, Lindblad I, Emtner M, Punga AR (2017) Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: a pilot study. Muscle Nerve 56:207–214. https://doi.org/10.1002/mus.25493
Westerberg E, Molin CJ, Spörndly Nees S, Widenfalk J, Punga AR (2018) The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: a single-subject design study. Medicine (Baltimore). 97:e11510. https://doi.org/10.1097/MD.0000000000011510
Wiendl H, Meisel A et al (2023) Diagnostik und Therapie myasthener Syndrome, S2k-Leitlinie, 2022, DGN, in: Deutsche Gesellschaft für Neurologie (Hrsg.), Leitlinien für Diagnostik und Therapie in der Neurologie. Online: www.dgn.org/leitlinien (abgerufen am 20.01.204)
Wiesinger GF, Quittan M, Nuhr M, Volc-Platzer B, Ebenbichler G, Zehetgruber M, Graninger W (2000) Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. Arch Phys Med Rehabil 81:1–5. https://doi.org/10.1016/s0003-9993(00)90212-0
Wong SH, Nitz JC, Williams K, Brauer SG (2014) Effects of balance strategy training in myasthenia gravis: a case study series. Muscle Nerve. 49:654–660. https://doi.org/10.1002/mus.24054
Young P, De Jonghe P, Stögbauer F, Butterfass-Bahloul T (2008) Treatment for Charcot-Marie-Tooth disease. Cochrane Database Syst Rev 1:CD006052. https://doi.org/10.1002/14651858.CD006052.pub2
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Schröter, C. (2024). Rehabilitation bei neuromuskulären Erkrankungen. In: Frommelt, P., Thöne-Otto, A., Grötzbach, H. (eds) NeuroRehabilitation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-66957-0_12
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