Abstract
Dementias and depressions are among the major widespread diseases of the twenty-first century, whose significance is constantly growing in ever ageing populations. The most effective measures to prevent them are not therapeutic but prophylactic. At the same time, these measures also increase physical and psychological well-being and they preserve cognitive performance. New estimates suggest that 30% of all dementias are preventable through lifestyle changes. Protective lifestyle factors include education, avoidance of obesity, physical activity, avoidance of smoking, normalization of blood pressure and blood sugar, maintenance of social relationships, and treatment of depression and hearing loss.
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References
Livingston G, Sommerlad A, Orgeta V et al (2017) Dementia prevention, intervention, and care. Lancet 390:2673–2734
Satizabal CL, Beiser AS, Chouraki V et al (2016) Incidence of dementia over three decades in the framingham heart study. N Engl J Med 374:523–532
Wu YT, Beiser AS, Breteler MMB et al (2017) The changing prevalence and incidence of dementia over time – current evidence. Nat Rev Neurol 13:327–339
Stern Y (2012) Cognitive reserve in ageing and Alzheimer’s disease. Lancet Neurol 11:1006–1012
Loef M, Walach H (2013) Midlife obesity and dementia: meta-analysis and adjusted forecast of dementia prevalence in the United States and China. Obesity (Silver Spring) 21:E51–E55
Nepal B, Brown LJ, Anstey KJ (2014) Rising midlife obesity will worsen future prevalence of dementia. PLoS One 9:e99305
Sofi F, Valecchi D, Bacci D et al (2011) Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med 269:107–117
Hamer M, Chida Y (2009) Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med 39:3–11
Swan GE, Lessov-Schlaggar CN (2007) The effects of tobacco smoke and nicotine on cognition and the brain. Neuropsychol Rev 17:259–273
Singh-Manoux A, Dugravot A, Fournier A et al (2017) Trajectories of depressive symptoms before diagnosis of dementia: a 28-Year follow-up study. JAMA Psychiatry 74:712–718
Cirrito JR, Disabato BM, Restivo JL et al (2011) Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans. Proc Natl Acad Sci USA 108:14968–14973
Sheline YI, West T, Yarasheski K et al (2014) An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice. Sci Transl Med:6:236re4
Heath L, Gray SL, Boudreau DM et al (2018) Cumulative antidepressant use and risk of dementia in a prospective cohort study. J Am Geriatr Soc 66:1948–1955
Wang YC, Tai PA, Poly TN et al (2018) Increased risk of dementia in patients with antidepressants: a meta-analysis of observational studies. Behav Neurol 2018:5315098
Kuiper JS, Zuidersma M, Oude Voshaar RC et al (2015) Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev 22:39–57
Lin FR, Metter EJ, O’Brien RJ et al (2011) Hearing loss and incident dementia. Arch Neurol 68:214–220
Sung YK, Li L, Blake C, Betz J, Lin FR (2016) Association of hearing loss and loneliness in older adults. J Aging Health 28:979–994
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GrĂ¼nder, G. (2022). Widespread Diseases of the Twenty-First Century. In: How Do We Want to Live?. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-64225-2_5
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DOI: https://doi.org/10.1007/978-3-662-64225-2_5
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