Summary
Under normal physiological conditions, cells of tight, Na+-reabsorbing urinary epithelia, such as the collecting tubule, are exposed to both anisosmotic and isosmotic volume stress. A common but poorly understood response of these cells to volume perturbation is the activation of mechanisms that restore volume to its original resting value. The purpose of this article is to review briefly what is currently known about volume regulatory processes in the collecting tubule, amphibian and mammalian bladder, and frog skin. Specifically, the role of solute loss and accumulation pathways, transcellular cross-talk mechanisms, and volume sensor/transducer systems will be discussed. Key questions in need of future research will be emphasized.
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© 1991 Springer Japan
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Strange, K. (1991). Volume Regulation in the Collecting Duct and Related Epithelia. In: Hatano, M. (eds) Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-35158-1_58
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DOI: https://doi.org/10.1007/978-3-662-35158-1_58
Publisher Name: Springer, Berlin, Heidelberg
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