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Secretory Lysosomes and the Production of Exosomes

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Unusual Secretory Pathways: From Bacteria to Man

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Eukaryotic cells secrete proteins either by the so-called constitutive secretion involving vesicular transport and exocytosis or by the regulated secretion of storage granules upon proper stimulation.1,2 Only recently has one become aware that alternative mechanisms operate that may account for the secretion of specific membrane and cytotoxic proteins. Indeed, accumulating evidence indicates that cellular compartments displaying intralumenal membrane vesicles, collectively named multivesicular bodies (MVBs), fuse with the plasma membrane in an exocytic manner. During exocytosis, the 60 to 80 nm membrane vesicles present in the lumen of MVBs are released into the extracellular environment. The secreted membrane vesicles are called exosomes.3–6

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  1. Graça Raposo
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  2. Michel Vidal
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  3. Hans Geuze
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Raposo, G., Vidal, M., Geuze, H. (1997). Secretory Lysosomes and the Production of Exosomes. In: Unusual Secretory Pathways: From Bacteria to Man. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22581-3_6

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  • DOI: https://doi.org/10.1007/978-3-662-22581-3_6

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