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Regulation of Spemann’s Organizer Formation

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The Vertebrate Organizer

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Abstract

Patterning the embryonic body relies on the complex integration of molecular information, normally involving a large number of signaling pathways. Activation of a specific pathway can determine the character of a specific region, cell or tissue, such as the embryonic organizer, notochord cells or neuronal tissue. In recent years, it has been demonstrated that the function of some signaling pathways amounts to negative regulation of other genes or factors, thereby constraining their effect both temporally and spatially. The timing and position of such regulators is crucial for the synchronization of developmental processes and the correct organization of the future organs and tissues of the body.

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Authors and Affiliations

  1. Department of Cellular Biochemistry and Human Genetics, Hebrew University-Hadassah Medical School, P.O.Box 12272, 91120, Jerusalem, Israel

    Abraham Fainsod

  2. Cutaneous Biology Research Center, Mass. General Hospital, Harvard University, Building 149, 13th St., Charlestown, MA, 02129, USA

    Vered Levy

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  1. Abraham Fainsod
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  2. Vered Levy
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  1. FB9 Department of Zoophysiology, University Duisburg-Essen, Universitätsstraße 5, 45117, Essen, Germany

    Horst Grunz

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Fainsod, A., Levy, V. (2004). Regulation of Spemann’s Organizer Formation. In: Grunz, H. (eds) The Vertebrate Organizer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10416-3_7

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  • DOI: https://doi.org/10.1007/978-3-662-10416-3_7

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