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Onkologie

  • Conference paper
90. Kongreß

Part of the book series: Verhandlungen der Deutschen Gesellschaft für Innere Medizin ((VDGINNERE,volume 90))

  • 31 Accesses

Zusammenfassung

Maligne Lymphome vom B-Zelltyp sind charakterisiert durch eine monoklonale Proliferation von B-Lymphozyten und Akkumulation von bestimmten Reifungsstufen. Die normale Proliferation und Differenzierung von B-Zellen in Plasmazellen und die Immunglobulinsynthese wird durch T-Helfer- und T-Suppressorzellen reguliert. Es wurde vermutet, daß T-Zellen eine wichtige Rolle in der Regulation auch bei B-Zellneoplasien spielen: Zahlreiche Studien haben übereinstimmend ergeben, daß bei Patienten mit chronischer lymphatischer Leukämie (CLL) vom B-Typ im peripheren Blut T-Zellen vermehrt sind [8] und daß das Verhältnis der T4 (Helfer)- zu den T8 (Suppressor)-Zellen zugunsten der Suppressorzellen verschoben ist [6, 7]. Eine vermehrte Suppressoraktivität könnte für den Antikörpermangel bei CLL verantwortlich sein. Ergebnisse von funktionellen Studien sind widersprüchlich [1–4]. Es ist denkbar, daß über sekundäre Effekte hinaus das T-Zellsystem eine Bedeutung für die Pathogenese von B-Zellneoplasien hat.

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Author information

Author notes

  1. M. Betzler

    Present address: Abt. Chirurgie, Klinikum, Universität Heidelberg, Deutschland

Authors and Affiliations

  1. Med. Univ.-Poliklinik, Heidelberg, Deutschland

    B. Dörken, A. Pezzutto & W. Hunstein

  2. Zentrum, Klinikum Mannheim, Fakultät für Klin. Medizin Mannheim, Universität Heidelberg, Deutschland

    M. E. Heim (Onkolog.) & H. Rademacher (Onkolog.)

  3. Institut für Klin. Radiologie, Klinikum Mannheim, Fakultät für Klin. Medizin Mannheim, Universität Heidelberg, Deutschland

    E. Wetzel

  4. Duisburg und Institut für Röntgentherapie und Nuklearmedizin der Städt. Kliniken, Med. Klinik II, St.-Johannes-Hospital, Duisburg, Deutschland

    R. Donhuijsen-Ant, R. Fuchs, M. Schroeder, M. Westerhausen, R. Frank & H.-Br. Makoski

  5. Essen, Deutschland

    C. R. Meier & K. Albrecht

  6. Ernst-Boehringer-Institut für Arzneimittelforschung, II. Med. Univ.-Klinik Wien, Wien, Österreich

    C. G. Schmidt, H. Ludwig, W. Scheithauer, E. Fritz, R. Flener, P. Swetly, U. Janssen & B. de Pauw

  7. Abt. Hämatologie, St.-Radboud-Hospital, Nijmegen, Holland

    H. Ludwig, W. Scheithauer, E. Fritz, R. Flener, P. Swetly, U. Janssen & B. de Pauw

  8. Abt. Innere Medizin III, Tumorzentrum, Klinikum der Universität Ulm, Deutschland

    W. Schreml, M. Lang, C. Raizner & F. Porzsolt

  9. Abt. Strahlentherapie, Tumorzentrum, Klinikum der Universität Ulm, Deutschland

    E. M. Röttinger

  10. Abt. Allgemeinchirurgie, Deutschland

    O. Kleine

  11. Abt. Gynäkologie und Geburtshilfe, Deutschland

    G. Geier

  12. Med. Klinik A und Abt. Zytopathologie, Universität Düsseldorf, Deutschland

    M. Winkelmann, M. Jeuck, R. E. Scharf, P. Pfitzer & W. Schneider

  13. III. Med. Klinik und Poliklinik, Universität Gießen, Deutschland

    S. Henninger, H. Stracke & H. Schatz

  14. Institut der Universität Gießen, Deutschland

    U. Wagner (Onkolog.) & J. Kracht (Onkolog.)

  15. Poliklinik — Tumorforschung, Innere Univ.-Klinik, Essen, Deutschland

    C. G. Schmidt, R. Osieka, S. Ohl, A. Miller, E. Kurschel & R. Pannenbäcker

  16. Med. Univ.-Klinik, Abt. A, Münster, Deutschland

    W. Hiddemann, R. Springefeld & Th. Büchner

  17. Med. Univ.-Klinik I, Köln, Deutschland

    Th. Büchner, Th. Gheorghiu & H. O. Klein

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  1. B. Dörken
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  38. H. Schatz
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  39. U. Wagner
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© 1984 Springer-Verlag Berlin Heidelberg

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Dörken, B. et al. (1984). Onkologie. In: 90. Kongreß. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 90. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-85457-6_63

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  • DOI: https://doi.org/10.1007/978-3-642-85457-6_63

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0342-9

  • Online ISBN: 978-3-642-85457-6

  • eBook Packages: Springer Book Archive

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