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Radiation Injury of the Lung: Experimental Studies, Observations After Radiotherapy and Total Body Irradiation Prior to Bone Marrow Transplantation

  • Chapter
Radiopathology of Organs and Tissues

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The history of radiation research shows that clinical problems give rise to experimental studies and that, in turn, radiobiological findings contribute to the improvement of radiotherapeutic procedures. As long ago as 1922 Groover et al. (1922) and Hines (1922) described the clinical features of radiation-induced pneumonitis and fibrosis of the alveolar wall. Wintz (1923) paid special attention to the complications related to pneumonitis after radiotherapy for bronchial and mammary carcinoma. The clinical observation that the lung is a critical tissue in radiotherapy of organs of the chest wall or within the thorax led to intensive experimental investigations. At a relatively early stage the chronology of the pathological alterations was studied in rabbits (Englestad 1940). An excellent and fundamental review of injuries contributing to lung morbidity and organ dysfunction was published by Rubin and Casarett (1968).

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Authors and Affiliations

  1. Radiologisches Zentrum, Universitätsklinikum Essen, Hufelandstraße 55, 4300, Essen 1, Germany

    M. Molls Priv.-Doz., Dr.med. (Oberarzt)

  2. Akademie des Sanitats- und Gesundkeitswesens der Bundeswehr, Neuherbergstraße 11, 8000, München 45, Germany

    D. van Beuningen Professor Dr. (Oberfeldarzt)

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  1. M. Molls Priv.-Doz., Dr.med.
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Editors and Affiliations

  1. Strahlenklinik und Poliklinik, Universitätsklinikum der Gesamthochschule Radiologisches Zentrum, Hufelandstraße 55, W-4300, Essen 1, Germany

    Eberhard Scherer

  2. Institut für Medizinische Strahlenphysik und Strahlenbiologie, Universitätsklinikum der Gesamthochschule, Hufelandstraße 55, W-4300, Essen 1, Germany

    Christian Streffer

  3. Department of Radiation Biology, The Medical College of St. Bartholomew’s Hospital, Charterhouse Square, London, EC1M 6BQ, UK

    Klaus-Rüdiger Trott

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Molls, M., van Beuningen, D. (1991). Radiation Injury of the Lung: Experimental Studies, Observations After Radiotherapy and Total Body Irradiation Prior to Bone Marrow Transplantation. In: Scherer, E., Streffer, C., Trott, KR. (eds) Radiopathology of Organs and Tissues. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83416-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-83416-5_13

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